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Interaction Between Leucine And Phosphodiesterase 5 Inhibition In Modulating Insulin Sensitivity And Lipid Metabolism, Lizhi Fu, Fenfen Li, Antje Bruckbauer, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Bingzhong Xue, Michael B. Zemel
Interaction Between Leucine And Phosphodiesterase 5 Inhibition In Modulating Insulin Sensitivity And Lipid Metabolism, Lizhi Fu, Fenfen Li, Antje Bruckbauer, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Bingzhong Xue, Michael B. Zemel
Biology Faculty Publications
Purpose: Leucine activates SIRT1/AMP-activated protein kinase (AMPK) signaling and markedly potentiates the effects of other sirtuin and AMPK activators on insulin signaling and lipid metabolism. Phosphodiesterase 5 inhibition increases nitric oxide–cGMP signaling, which in turn exhibits a positive feedback loop with both SIRT1 and AMPK, thus amplifying peroxisome proliferator-activated receptor γ co-activator α (PGC1α)-mediated effects. Methods: We evaluated potential synergy between leucine and PDE5i on insulin sensitivity and lipid metabolism in vitro and in diet-induced obese (DIO) mice. Results: Leucine (0.5 mM) exhibited significant synergy with subtherapeutic doses (0.1–10 nM) of PDE5-inhibitors (sildenafil and icariin) on fat oxidation, nitric oxide …
Methods Of Competing Risks Analysis Of End-Stage Renal Disease And Mortality Among People With Diabetes, Hyun J. Lim, Xu Zhang, Roland Dyck, Nathaniel Osgood
Methods Of Competing Risks Analysis Of End-Stage Renal Disease And Mortality Among People With Diabetes, Hyun J. Lim, Xu Zhang, Roland Dyck, Nathaniel Osgood
Mathematics and Statistics Faculty Publications
Background: When a patient experiences an event other than the one of interest in the study, usually the probability of experiencing the event of interest is altered. By contrast, disease-free survival time analysis by standard methods, such as the Kaplan-Meier method and the standard Cox model, does not distinguish different causes in the presence of competing risks. Alternative approaches use the cumulative incidence estimator by the Cox models on cause-specific and on subdistribution hazards models. We applied cause-specific and subdistribution hazards models to a diabetes dataset with two competing risks (end-stage renal disease (ESRD) or death without ESRD) to measure …
Family Functioning In Children With Chronic Illness Compared With Healthy Controls: A Critical Review, Catherine B. Mcclellan, Lindsey L. Cohen
Family Functioning In Children With Chronic Illness Compared With Healthy Controls: A Critical Review, Catherine B. Mcclellan, Lindsey L. Cohen
Psychology Faculty Publications
The impact of chronic illnesses upon children and their families can range from minimal disruptions to severe distress and functional limitations. Advances in medical care and technology have increased the lifespan of children with chronic illness as well as decreased the frequency of readily observable disease impacts on this population. To enhance our understanding of the more subtle, but equally important, impacts of pediatric chronic illnesses, researchers have expanded the domains assessed to include measurement of child adjustment and family functioning. Understanding the nature and development of the deficits in family functioning is key to the formulation of interventions designed …