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Regulation Of Innate Immune Cell Response Under Sub-Acute/Chronic Inflammatory Conditions, Shuo Niu

Biology Dissertations

Sub-acute/chronic inflammatory diseases are often associated with altered inflammatory response, leading to increased host vulnerability to secondary inflammatory challenges. In the first study, by employing streptozotocin (STZ)-induced diabetes in mice, we further investigate mechanisms leading to enhanced polymorphonuclear leukocytes (PMN) response under hyperglycemia. We show that existence of a proinflammatory state associated with broad increases of macrophages in various organs plays a dominant role in promoting PMN response in diabetic mice. Studies of PMN infiltration during zymosan-induced peritonitis reveal that hyperglycemia enhances PMN recruitment through increasing F4/80⁺ macrophages in the peritoneal cavity. Insulin reversal of hyperglycemia reduces peritoneal macrophage …