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Articles 1 - 11 of 11
Full-Text Articles in Entire DC Network
In Memoriam
Appalachia
Tributes to: John Edward Mullens, who died December 3, 2022, just after receiving the Distinguished Service Award from the Appalachian Mountain Club, which he served as a volunteer in many roles over many years; George DeWolfe, who died July 2, 2023 after a long career as a photographer that included many contributions to AMC projects; and Douglas W. and Mary Louise Backus Rankin, geologist and China historian who’d met working for AMC in the 1950s and who did mountain research together for years before their deaths in 2015 and 2020.
Teaching Wonder: Essays And Reflections From The National Parks System, James A. Hubbard
Teaching Wonder: Essays And Reflections From The National Parks System, James A. Hubbard
Dartmouth College Master’s Theses
In The Sense of Wonder (1965), acclaimed environmentalist Rachel Carson offers guidance for adults helping children explore nature and cultivate an enduring interest in the outdoors. Fondly drawing upon excursions in coastal Maine with her grandnephew Roger Christie, Carson illustrates the powerful impact of simply accompanying children in nature and letting their curiosity and questioning guide the adventure. Despite her immense knowledge in earth sciences, she made a concerted effort not to share technical vocabulary with Roger, believing that doing so might belittle his joy in their surroundings. Her work has inspired me throughout my career as a fourth grade …
News And Notes
Appalachia
Susan Arnold is named interim president of the Appalachian Mountain Club. The shelter at Imp Campsite near the Carter Range is renovated using historic techniques. Echo Lake Camp turns 100. AMC’s Maine Woods property is certified an International Dark Sky Park.
The Geography Of Philanthropy: With Three Meditations On Humility, W. Kent Olson
The Geography Of Philanthropy: With Three Meditations On Humility, W. Kent Olson
Appalachia
A former Appalachia editor considers the motivations behind the creation of Maine’s Acadia National Park on its centennial.
The Landscape Of Extreme Genomic Variation In The Highly Adaptable Atlantic Killifish, Noah M. Reid, Craig E. Jackson, Don Gilbert, Patrick Minx, Michael J. Montague, Thomas H. Hampton, Lily W. Helfrich, Benjamin L. King, Diane E. Nacci, Neel Aluru
The Landscape Of Extreme Genomic Variation In The Highly Adaptable Atlantic Killifish, Noah M. Reid, Craig E. Jackson, Don Gilbert, Patrick Minx, Michael J. Montague, Thomas H. Hampton, Lily W. Helfrich, Benjamin L. King, Diane E. Nacci, Neel Aluru
Dartmouth Scholarship
Understanding and predicting the fate of populations in changing environments require knowledge about the mechanisms that support phenotypic plasticity and the adaptive value and evolutionary fate of genetic variation within populations. Atlantic killifish (Fundulus heteroclitus) exhibit extensive phenotypic plasticity that supports large population sizes in highly fluctuating estuarine environments. Populations have also evolved diverse local adaptations. To yield insights into the genomic variation that supports their adaptability, we sequenced a reference genome and 48 additional whole genomes from a wild population. Evolution of genes associated with cell cycle regulation and apoptosis is accelerated along the killifish lineage, which …
The Interrelationships Of Placental Mammals And The Limits Of Phylogenetic Inference, James E. Tarver, Mario Dos Reis, Siavash Mirarab, Raymond J. J. Moran, Sean Parker, Joseph E. O'Reilly, Benjamin L. King, Mary J. O'Connell, Robert J. Asher, Tandy Warnow, Kevin J. Peterson, Philip C.J. Donoghue, Davide Pisani
The Interrelationships Of Placental Mammals And The Limits Of Phylogenetic Inference, James E. Tarver, Mario Dos Reis, Siavash Mirarab, Raymond J. J. Moran, Sean Parker, Joseph E. O'Reilly, Benjamin L. King, Mary J. O'Connell, Robert J. Asher, Tandy Warnow, Kevin J. Peterson, Philip C.J. Donoghue, Davide Pisani
Dartmouth Scholarship
Placental mammals comprise three principal clades: Afrotheria (e.g., elephants and tenrecs), Xenarthra (e.g., armadillos and sloths), and Boreoeutheria (all other placental mammals), the relationships among which are the subject of controversy and a touchstone for debate on the limits of phylogenetic inference. Previous analyses have found support for all three hypotheses, leading some to conclude that this phylogenetic problem might be impossible to resolve due to the compounded effects of incomplete lineage sorting (ILS) and a rapid radiation. Here we show, using a genome scale nucleotide data set, microRNAs, and the reanalysis of the three largest previously published amino acid …
Cd2ap Regulates Sumoylation Of Cin85 In Podocytes, Irini Tossidou, Rainer Niedenthal, Malte Klaus, Beina Teng, Kirstin Worthmann, Benjamin King, Kevin Peterson
Cd2ap Regulates Sumoylation Of Cin85 In Podocytes, Irini Tossidou, Rainer Niedenthal, Malte Klaus, Beina Teng, Kirstin Worthmann, Benjamin King, Kevin Peterson
Dartmouth Scholarship
Podocytes are highly differentiated and polarized epithelial cells located on the visceral side of the glomerulus. They form an indispensable component of the glomerular filter, the slit diaphragm, formed by several transmembrane proteins and adaptor molecules. Disruption of the slit diaphragm can lead to massive proteinuria and nephrotic syndrome in mice and humans. CD2AP is an adaptor protein that is important for the maintenance of the slit diaphragm. Together with its paralogue, CIN85, CD2AP belongs to a family of adaptor proteins that are primarily described as being involved in endocytosis and downregulation of receptor tyrosine kinase activity. We have shown …
Morpholino Gene Knockdown In Adult Fundulus Heteroclitus: Role Of Sgk1 In Seawater Acclimation, Emily G. Notch, Joseph R. Shaw, Bonita A. Coutermarsh, Marisa Dzioba, Bruce A. Stanton
Morpholino Gene Knockdown In Adult Fundulus Heteroclitus: Role Of Sgk1 In Seawater Acclimation, Emily G. Notch, Joseph R. Shaw, Bonita A. Coutermarsh, Marisa Dzioba, Bruce A. Stanton
Dartmouth Scholarship
The Atlantic killifish (Fundulus heteroclitus) is an environmental sentinel organism used extensively for studies on environmental toxicants and salt (NaCl) homeostasis. Previous research in our laboratory has shown that rapid acclimation of killifish to seawater is mediated by trafficking of CFTR chloride channels from intracellular vesicles to the plasma membrane in the opercular membrane within the first hour in seawater, which enhances chloride secretion into seawater, thereby contributing to salt homeostasis. Acute transition to seawater is also marked by an increase in both mRNA and protein levels of serum glucocorticoid kinase 1 (SGK1) within 15 minutes of transfer. …
Regulation Of Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) By Serum- And Glucocorticoid-Inducible Kinase (Sgk1), J. Denry Sato, M. Christine Chapline, Renee Thibodeau, Raymond A. Frizzell, Bruce A. Stanton
Regulation Of Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) By Serum- And Glucocorticoid-Inducible Kinase (Sgk1), J. Denry Sato, M. Christine Chapline, Renee Thibodeau, Raymond A. Frizzell, Bruce A. Stanton
Dartmouth Scholarship
Background: Serum- and glucocorticoid-inducible kinase-1 (SGK1) increases CFTR Cl currents in Xenopus oocytes by an unknown mechanism. Because SGK increases the plasma membrane expression of other ion channels, the goal of this paper was to test the hypothesis that SGK1 stimulates CFTR Cl currents by increasing the number of CFTR Cl channels in the plasma membrane. Methods: CFTR Cl currents were measured in Xenopus oocytes by the two-electrode voltage clamp technique, and CFTR in the plasma membrane was determined by laser scanning confocal microscopy. Results: wt-SGK1 stimulated CFTR Cl currents by 42% and increased the amount of CFTR in the …