Digital Commons Network^™

An Eco-Inspired Emulsion Membrane Harnessed With Waste Vegetable Oil For Effective Separation Of Ibuprofen: Insights Into Stability, Performance, And Kinetics, Huma Warsi Khan, A. Vijaya Bhaskar Reddy, Parvez Alam Khan, Samsur Akm Rahman, Muhammad Moniruzzaman

Publications and Research

Emulsion liquid membranes (ELMs) have emerged as excellent alternatives for the separation and recovery of biologically active drugs (BADs) from industrial waste at trace concentrations. Conventional ELMs generally utilize toxic petroleum-based solvents (PBS) that pose environmental and health risks. Although virgin vegetable oils have been appeared as sustainable alternatives to PBS, their widespread application is limited by economic constraints, resource sustainability, and competition with the food supply. In contrast, waste vegetable oil (WVO) represents an abundant, low-cost, and eco-friendly alternative, yet its potential as a green diluent for ELMs remains largely unexplored. To address this challenge, present study investigated the …

Growing, Connecting, And Reflecting: Interpersonal Communication In Relationships, Gordon Alley-Young

Open Educational Resources

"Growing, Connecting, and Reflecting: Interpersonal Communication in Relationships" by Gordon Alley-Young is an Open Educational Resource (OER) textbook exploring communication in interpersonal relationships. The text emphasizing that communication is a collaborative, co-creation of meaning across many contexts and channels. The text recognizes the pervasive influence of culture on communication to recognize how our diverse backgrounds shape relational dynamics and dialogue. Topics and themes explored in the text include: self-concept, perception, cultural awareness, effective listening, emotion, verbal and nonverbal communication, relational climates and conflict, and the formation and evolution of foundational interpersonal relationships. The text encourages individual reflection on the reader's …

Hydration-Tunable Ionic Liquid-In-Oil Microemulsions For Increased Transdermal Delivery Of High-Molecular-Weight Proteins, Roy Jabidash, Kiyohiro Toyofuku, Rie Wakabayashi, Yoshirou Kawaguchi, Noriho Jeffrey Kamiya, Muhammad Moniruzzaman, Masahiro Goto

Publications and Research

Transdermal delivery of high-molecular-weight proteins is challenging because of their large molecular size and hydrophilicity, and the barrier properties of the stratum corneum. We report a hydrated ionic liquid-in-oil (HIL/O) microemulsion for transdermal delivery of high-molecular-weight proteins. A biocompatible ionic liquid (IL) composed of cholinium cation and propionate anion, optimized at 45 wt% hydration, was developed as a protein-compatible solubilization medium that dissolved ovalbumin (molecular mass ∼ 45 kDa) and bovine serum albumin (molecular mass ∼ 66 kDa), whereas lower hydration levels were insufficient for effective protein dissolution. Following solubilization, circular dichroism spectroscopy showed recovery of the native-like secondary structures …

Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao

Dissertations, Theses, and Capstone Projects

Osteosarcoma (OS), the most common primary bone malignancy of children and young adults, is intrinsically radioresistant, and outcomes for patients with unresectable or metastatic disease have not improved in over four decades. Single-dose radiation therapy (SDRT) is a potent modality against radioresistant, highly vascularized sarcomas, but its application in OS is constrained by dose-dependent normal tissue toxicity. Radiosensitizers achieving tumor control at lower doses therefore offer a direct route to widening the therapeutic window. Critically, OS radioresistance is not tumor-cell-autonomous. It emerges from two coordinated compartments: aberrant DNA repair and antioxidant capacity intrinsic to the tumor cell, and a radioprotective, …

Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric

Dissertations, Theses, and Capstone Projects

Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder with a lifetime prevalence of 5-6% in men, and 10-12% in women (National Center for PTSD). Generalized anxiety disorder (GAD) is a highly prevalent anxiety- and depression-related psychiatric disorder with a lifetime prevalence of 1-2% in men, and 3-4% in women (National Institutes of Health). Both of these disorders disproportionately affect women. A hallmark feature of both disorders is the maladaptive generalization of fear, in which defensive responses extend beyond the original traumatic or threatening stimulus to neutral or unrelated cues. This overgeneralization can become debilitating, disrupting cognitive, emotional, and …

Analysis Of Diterpenoid Alkaloids From American Aconitum Using Lc-Ms Metabolomic Methods, Yi Zhao

Dissertations, Theses, and Capstone Projects

Analysis of Diterpenoid Alkaloids from American Aconitum Using LC-MS Metabolomic Methods

by

Yi Zhao

Advisor: Edward J. Kennelly

Aconitum plants have been used as a traditional medicine in Asian countries for millennia to treat pain, rheumatism, syncope, fever, and other conditions. These therapeutic effects are mainly due to the bioactive diterpenoid alkaloids accumulated in the roots. Comparing with the large records and studies of Asian Aconitum and their medicinal use and the broad bioactive compounds, American Aconitum has been rarely investigated, not to mention how American Aconitum has been used medicinally. Based on previous phylogenetic and chemotaxonomic studies of Aconitum …

Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano

Dissertations, Theses, and Capstone Projects

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein condensates that regulate mRNA storage, translational repression, and decay. While the biochemical principles governing condensate assembly have been extensively studied in vitro, how P-body organization is established and dynamically regulated in vivo to control specific mRNA populations remains poorly understood. This dissertation investigated the molecular and cellular mechanisms that govern P-body architecture and function in the Drosophila melanogaster female germline. First, I identified the conserved LSm protein Trailer Hitch (Tral) as a central organizer of P-body architecture. Using quantitative confocal and super-resolution microscopy combined with chemical perturbations, I showed that Tral coordinates the …

Optimizing Nanoparticle Quality And Function In Applied Research, Angela M. Fried

Dissertations, Theses, and Capstone Projects

Radiology tests are among the fastest-growing categories of diagnostic analysis, and the gold standard of radiology tests is MRI.  MRI can be more informative if a contrast agent is used, and the standard of care contrasting agents (CA) are gadolinium-based.  Gadolinium is a heavy metal, toxic, and contraindicated for renal-compromised patients and the critically ill.  We propose a nanogel (NG) vehicle for an alternative organic CA.  CNs like 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) and its derivatives have a variety of medical and industrial uses.  These cyclic CNs are stable, synthetic radicals with distinctive EPR/ESR signals and are helpful for various experimental applications, from …

The Role Of Temperament In Criminal Trajectories: Development, Stability, And Predictive Power Across The Life Course, Joshua A. Lang

Dissertations, Theses, and Capstone Projects

Temperament, an individual's largely innate tendency to experience and regulate responses to their environment, has long been studied but was only recently introduced as a primary predictor of criminal behavior (DeLisi & Vaughn, 2014). While prior criminological theories have incorporated temperament-related constructs, such as negative affect (Agnew, 1992; Moffitt, 1993) and self-control (Gottfredson & Hirschi, 1990), no other theory has explicitly positioned temperament as the central factor in offending. DeLisi and Vaughn’s temperament-based theory of antisocial behavior posits that individuals with low effortful control and high negative emotionality—features of a difficult temperament—are more likely to engage in criminal behavior. Despite …

The Role Of External Factors In Shaping Carbohydrate Conformational Landscapes, Murat Yaman

Dissertations, Theses, and Capstone Projects

Carbohydrates (glycans) are among the most structurally diverse biomolecules and participate in a wide range of biological processes, including molecular recognition, cell adhesion, immune response, host-pathogen interactions, and cellular signaling. Their biological functions are governed by a complex interplay between sequence, stereochemistry, conformational flexibility, and environmental factors. However, the structural heterogeneity and dynamic nature of glycans present significant challenges for both experimental characterization and theoretical modeling. In particular, the relationships between glycan structure, conformational dynamics, and the resulting potential energy surfaces remain incomplete.

This dissertation investigates how external factors modulate the potential energy surfaces of carbohydrates through a combination of …

Parenthood And Re-Appraisal Of Childhood Maltreatment, Gayathri Cheran

Dissertations, Theses, and Capstone Projects

Background: Child maltreatment is associated with poorer physical and mental health outcomes across the lifespan.  Individuals’ appraisals of childhood maltreatment have important implications for these outcomes.  Appraisal is shaped by biological, psychological, and social-cultural factors, each of which undergoes change in parenthood.  Parenthood may prompt re-appraisal of childhood maltreatment in that being a parent evokes one’s experience of being parented.

Hypotheses: (1) Re-appraisal will be more likely in parents than non-parents.  In parents, re-appraisal will be more likely among: (2) primiparous parents, (3) parents with offspring of the same sex, and (4) parents who experienced maltreatment older in childhood (at …

The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose

Dissertations, Theses, and Capstone Projects

Tobacco is one of the most widely used substances across the United States; tobacco consumption is linked with several diseases and is one of the leading causes of preventable death in the country. Nicotine is the active substrate found in tobacco products, acting as a stimulant, which reinforces continued use. The introduction of tobacco-free options such as e-cigarettes and oral pouches has driven an increase in nicotine exposure across the population, especially in young adults. Acute nicotine use induces neuroadaptations in the mesolimbic dopaminergic system, which mediates reinforcement learning and addiction, that potentiates reward-related neurotransmission. Furthermore, there are clinical studies …

Retrieval Information From Working Memory: The Output Gating Framework Perspective And Its Underlying Processes, Chen Tiferet-Dweck

Dissertations, Theses, and Capstone Projects

Working memory (WM) keeps information accessible and available for further processing. However, not all the information we maintain in WM is behaviorally relevant at any given moment. To act effectively, we must dynamically control which memory representations are accessed to support ongoing goal-directed behavior. While the mechanisms underlying the selection of single items from WM access are comparatively well-studied, less is known about the principles governing multi-item access. Existing models of WM access imply that selecting multiple items should take longer and be more error-prone than single-item access. Yet, paradoxically, prior studies have shown that retrieving all items in WM …

‘A Sense Of The Sea’: Grassroots Culture, Care, And Endurance In Swansea, Cymru, Katy Clark

Dissertations, Theses, and Capstone Projects

This thesis argues that under present conditions, everyday political-aesthetic life is not only about resistance or reproduction but about holding: the work of keeping people, practices, and attachment present and oriented as conditions change. Holding takes the form of care and maintenance; as practices of making, assembling, and imagining; and as the work that keeps open the possibility of renewed attachment to public things and to each other. In the field, this was named as ‘a sense of the sea’, an affective register characterized by wariness, attunement, attentiveness, orientation, and endurance. I am calling this a fragile infrastructure of …

Urban Counterpoint (1992–2003): The Piano Music Of Ed Bland, Joseph Vaz

Dissertations, Theses, and Capstone Projects

This dissertation analyzes the piano music of Ed Bland, a politically and philosophically vocal composer active in the second half of the twentieth century, whose music draws on both the European and American twentieth-century avant-garde, and on African American vernacular music genres from ragtime to hip-hop. A review of the historical and personal context for these pieces, and a detailed examination of the compositional processes used in this music, work together to demonstrate how Bland thought about the relationship between different musical genres and languages.

Through this combination of theory of musical genre, historical and biographical study, and detailed analysis …

New York City Women’S Experiences With Perinatal Depression Inquiries, Diagnosis, And Treatment Initiation, Caterina Pisciotta

Dissertations, Theses, and Capstone Projects

Perinatal depression represents a significant public health concern, yet many women who experience depression symptoms during the perinatal period (either during pregnancy and/or after birth) do not receive treatment. Initiatives, such as ThriveNYC, were designed to address these gaps by screening and treating perinatal women for maternal depression, integrating screening into routine perinatal care and strengthening pathways to treatment. Using representative survey data collected between 2016 and 2021 via the Center for Disease Control and Prevention’s Pregnancy Risk Assessment Monitoring System (PRAMS), this study examined trends in perinatal depression inquiries (a proxy for “screening”) and postpartum diagnosis, as well as …

Catalytic Synthesis Of Protoberberine Alkaloids And Their Evaluation As Selective Dopamine Receptor Ligands, Ashok Reddy Gudipally

Dissertations, Theses, and Capstone Projects

Dopamine regulates motor control, cognition, reward, motivation, and neuroendocrine signaling. Disruption of dopaminergic neurotransmission is closely linked to central nervous system disorders, including Parkinson’s disease, schizophrenia, addiction, and related neuropsychiatric conditions. Because these functions are mediated by multiple dopamine receptor subtypes with distinct roles in physiology and disease, the discovery of subtype-selective ligands remains an important goal in neuropharmacology. Within this context, protoberberine alkaloids, particularly tetrahydroprotoberberines (THPBs), are attractive molecular frameworks because they combine structural complexity with broad biological relevance, including measurable activity in CNS-related diseases. Prior work from our laboratory and others established (–)-stepholidine (1.60) as an important lead …

Cognitive-Affective And Somatic Depressive Symptom Domains Related To Psychological Mechanisms And Sociodemographic Factors, Danielle B. Hazeltine

Dissertations, Theses, and Capstone Projects

Major depressive disorder is prevalent, chronic, and heterogeneous, including cognitive- affective (e.g., maladaptive beliefs or thinking patterns and sad mood) and somatic (e.g., fatigue, appetite, or sleep changes) symptom domains. While depression domains have been long theorized, research examining psychological mechanisms underlying this distinction is limited. Preliminary research suggests cognitive-affective symptoms relate more strongly to cognitive mechanisms (cognitive bias, perseverative thought), somatic symptoms relate more strongly to behavioral mechanisms (behavioral inhibition/activation), and gender, race, and ethnicity moderate these relationships. This study examined whether cognitive-affective and somatic symptom domains differentially relate to cognitive and behavioral mechanisms, and whether these relationships are …

Alzheimer’S Disease And Related Dementias Risk Profiles And Health Literacy Among South Asian Seniors, Sandra A. Kennedy

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease and Related Dementias (ADRD) pose significant health challenges globally, with South Asian seniors in the United States facing elevated risks due to high rates of cardiovascular disease, diabetes, and limited health literacy. This study assessed dementia literacy and the prevalence of cardiovascular, psychosocial, and lifestyle risk factors among South Asian seniors in New York City, utilizing community-based participatory research (CBPR) principles in collaboration with India Home, a community-based organization. Fifty-six (N=56) South Asian seniors aged 55 and older (M = 69.05, SD = 6.36), primarily of Indian or Bangladeshi origin, participated in the study. Data collection involved a …

Intimate Partner Violence And Emotion Regulation Among Emerging Adults: Investigating The Roles Of Dispositional Mindfulness And Executive Function In The Context Of A Laboratory-Induced Stress Paradigm, Mikell Bursky

Dissertations, Theses, and Capstone Projects

Intimate Partner Violence (IPV) is a major public health concern that impacts an estimated 10 million men and women in the United States annually. IPV refers to a range of physical, sexual or psychological forms of aggression committed against a current or former romantic partner in the context of a relationship. The highest rates of IPV are observed in emerging adulthood, a developmental period between the ages of 18 to 25 that is significant for the transition from adolescence into adulthood, and the establishment of first meaningful intimate relationships. Although distal risk factors for IPV such as violence in the …

Sec-Saxs And Sans Analyses Of The Talin•Vinculin Complex, Gilbert Reyes

Dissertations, Theses, and Capstone Projects

Focal adhesions (FA) are integrin-based cell-matrix adhesion sites composed of adaptor proteins that facilitate the generation of traction forces important for biological functions such as cell migration, embryo development, wound healing, tissue organization and stability, and immune responses. Mature FA are observed when both autoinhibited multi-domain scaffolding protein talin and membrane-cytoskeletal protein vinculin are activated and interact thus promoting the assembly and function of FA. While research has resolved truncated sections of autoinhibited talin and recruitment of vinculin due to mechanotransduction that exposes cryptic vinculin binding sites (VBS), little is known about the global modifications of full length talin in …

Bridging Data Gaps In Retinal Imaging: From Structural Domain Adaptation To Topology-Aware Synthesis, Gözde Merve Demirci

Dissertations, Theses, and Capstone Projects

Comprehensive visualization of the retina is essential for diagnosing and monitoring blinding diseases such as Diabetic Retinopathy and Retinopathy of Prematurity (ROP), where pathological changes often extend beyond a single field of view. Despite significant advances in automated retinal image analysis, clinical deployment remains limited by two fundamental data gaps: a structural learning gap, arising from scarce expert annotations and poor generalization across imaging domains, and a spatial coverage gap, caused by the difficulty of acquiring multi-view retinal images in fragile populations. Although these challenges are often addressed independently, this dissertation argues that they are tightly coupled: accurate, …

Mapping The Water Quality Of Jamaica Bay, New York (1996-2024): Principal Component Analysis And K-Means Clustering, Sneha Srivastava

Dissertations, Theses, and Capstone Projects

Jamaica Bay, located along the southeastern coast of New York City, acts as a biodiverse estuary of wetlands, meadows, and salt marsh islands. The purpose of this study is to analyze the water quality conditions of the region over time, comparing locations around the bay to identify hyperlocal features that influence larger trends in the hydrological system. Ten variables were used as water quality indicators, including total Kjeldahl nitrogen, salinity, pH, Secchi disk depth, and total phosphorus, among others, across five stations in the bay, between 1994 and 2024. After data cleaning and standardization methods were applied, principal component analysis …

Investigating The Role Of Striatal Cholinergic Interneuron D2 Receptors In Behavioral Flexibility, Janyn J. Alfred

Dissertations, Theses, and Capstone Projects

Dopamine (DA) and acetylcholine (ACh) interact within the striatum to shape reward-based learning and choice behavior. DA D2 receptors on cholinergic interneurons (CIN D2Rs) were genetically knocked out to investigate their role in choice allocation using a two-lever matching paradigm. Behaviorally, both knockout (KO) and wild-type (WT) mice learned the initial task equally well. When shifted to asymmetric matching schedules (VI-90 vs. VI-180), ideal matching predicts that mice should allocate exactly 67% of their total responses to the rich lever. Neither group matched as predicted by the matching law. Instead, the KO mice showed a pattern where the higher rate …

Scientific Uncertainty As Political Aggression: A Manifesto For Those Who Value Science And Want To Save It From State And Corporate Control, Stephen Demeo

Publications and Research

A manifesto is an opportunity to publicly express strongly held beliefs about a topic that is personally important to an author. It is analytical as it is creative. “Scientific Uncertainty as Political Aggression” is a manifesto that intersects science and politics. It urges those interested in science to examine two different but related topics: scientific uncertainty in measurement—what it is, how it is determined, why it’s important— and the magnification of uncertainty through legal and linguistic tactics used by right-wing politicians and politically supported corporations.

For some time now, the Republican Establishment has cast excessive doubt on scientific findings through …

Comm 11 Fundamentals Of Interpersonal Communication Textbook, Teresa A. Fisher

Open Educational Resources

A survey of interpersonal communication.

‘Passing’ The Baton Of Trauma: Queer Failure Of The Women’S Sport Policy Working Group’S Anti-Trans ‘Position’, Meredith M. Bagley, Mary Anne Taylor, Sarah F. Price

Publications and Research

Engaging in critical rhetorical theory and methodology, we interrogate the contemporary landscape of anti-trans backlash in women’s sport. Specifically, we read the ‘TERF wars’ (Pearce et al.) across critiques of biofeminism (Pape) and whiteness (Fischer) while drawing upon critical social science research into trauma-bonding, bullying, and the structural impacts of gender verification policies. Our analysis focuses on the Women’s Sports Policy Working Group (WSPWG), offering a trauma-informed reading of the WSPWG’s ‘Position’ statement to illuminate how lesbian female athletes who were previously slandered for failing to meet femininity norms in sport are unable to overcome that trauma to recognize and …

The Self-Aware Room: A Framework For Operational Self-Awareness In Evolvable Blended Environments, David B. Smith

Publications and Research

The Self-Aware Room (SAR) is a room-scale research environment developed within the larger Balanced Blended Space and Blended Reality Performance System research trajectory. Rather than treating the room as a conventional “smart” environment composed of fixed automation technologies, SAR approaches it as an evolvable blended environment made from physical, virtual, conceptual, sensory, computational, and performative relationships. Its defining feature is not any particular sensor, model, or output device, but the set of transformations through which physical activity becomes structured observation, bounded representation, interpreted state, governed decision, and mediated response.

This paper develops the conceptual and methodological foundations of SAR as …

Investigating The Links Between Iq, Emotion Dysregulation, And Respiratory Sinus Arrhythmia In Childhood Antisocial Behavior, Isley Jean-Pierre

Student Theses

This study examined relationships among cognitive ability, emotion dysregulation, physiological regulation, and antisocial behavior. Participants were 340 children ages 7-10. Caregivers reported on emotion regulation, aggression, and delinquency, and children completed cognitive assessments. Intellectual profiles were classified as even or uneven. No significant differences in aggression or delinquency were found between intellectual profiles. Emotion Regulation Checklist scores mediated relationships between VIQ and both aggression and delinquency. Resting RSA mediated the relationship between VIQ and delinquency, although the indirect effect was small, whereas RSA reactivity did not mediate either outcome. Overall, findings suggest that emotion regulation may be a more consistent …

Effect Of Food Resource, Preservation Method, And Preservation Duration On Larval Size Of Forensically Important Fly Species (Order: Diptera), John Zukowski

Student Theses

Forensic entomology is a vital discipline that can aid in the proceedings of criminal cases. Larval age and development are important aspects to consider when utilizing blow flies (Family: Calliphoridae) for estimates pertaining to the initial time of colonization (TOC), which contributes to postmortem interval (PMI) estimations. Thus, it is important to understand the factors that influence larval size and development, since larval size is commonly used as a proxy for age. Larvae of three species of flies, Lucilia sericata (Meigen), Calliphora vicina (Robineau-Desvoidy), and Phormia regina (Meigen), were reared on five different food resources. Specimens of L. sericata and …