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Clinically Translatable Approaches Of Inhibiting Tgf-Β To Target Cancer Stem Cells In Tnbc., Andrew Sulaiman, Sarah Mcgarry, Sai Charan Chilumula, Rohith Kandunuri, Vishak Vinod
Clinically Translatable Approaches Of Inhibiting Tgf-Β To Target Cancer Stem Cells In Tnbc., Andrew Sulaiman, Sarah Mcgarry, Sai Charan Chilumula, Rohith Kandunuri, Vishak Vinod
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Triple-negative breast cancer (TNBC) is a subtype of breast cancer that disproportionally accounts for the majority of breast cancer-related deaths due to the lack of specific targets for effective treatments. In this review, we highlight the complexity of the transforming growth factor-beta family (TGF-β) pathway and discuss how the dysregulation of the TGF-β pathway promotes oncogenic attributes in TNBC, which negatively affects patient prognosis. Moreover, we discuss recent findings highlighting TGF-β inhibition as a potent method to target mesenchymal (CD44+/CD24-) and epithelial (ALDHhigh) cancer stem cell (CSC) populations. CSCs are associated with tumorigenesis, metastasis, relapse, resistance, and diminished patient prognosis; …