Digital Commons Network^™

Assessment Of Achieved Systolic Blood Pressure In Newly Treated Hypertensive Patients Aged 60-79 Years Before And After Eighth Joint National Committee Recommendations, Michael S. Kelly, Joseph J. Saseen, Joel C. Marrs

Pharmacy Faculty Articles and Research

Objective:

To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update.

Methods:

A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60–79 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included. The mean first-achieved and last-stable SBPs of patients newly prescribed antihypertensive medications from 1 January 2012 to 31 December 31 2013 (before cohort) were compared …

Language Assessment In A Snap: Monitoring Progress Up To 36 Months, Jill Gilkerson, Jeffrey A. Richards, Charles R. Greenwood, Judy K. Montgomery

Communication Sciences and Disorders Faculty Articles and Research

This article describes the development and validation of the Developmental Snapshot, a 52-item parent questionnaire on child language and vocal communication development that can be administered monthly and scored automatically. The Snapshot was created to provide an easily administered monthly progress monitoring tool that enables parents to better recognize language milestones and offers professionals prompt information to fine-tune intervention strategies. Initial items were piloted by 15 families; refinement and further development of the instrument was conducted with parents of 308 typically developing children. Reliability and criterion validity metrics were examined on subsets of approximately 60 children who completed the Snapshot …

Social Media At Work: The Roles Of Job Satisfaction, Employment Status, And Facebook Use With Co-Workers, Brett W. Robertson, Kerk Kee

Communication Faculty Articles and Research

Limited research has studied workplace satisfaction in a computer-mediated context, particularly with the use of social media. Based on an analysis of an online survey of working adults (N=512) in various companies and organizations in a metropolitan area in Southern California, we tested the relationships among time spent on Facebook interacting with coworkers, employment status, and job satisfaction. Results show that an employee’s satisfaction at work is positively associated with the amount of time they spend on Facebook interacting with co-workers. Contrary to our initial predictions, results to the second and third hypotheses revealed that part time employees reported having …

All-Pay Auctions With Ties, Alan Gelder, Dan Kovenock, Brian Roberson

ESI Working Papers

We study the two-player, complete information all-pay auction in which a tie ensues if neither player outbids the other by more than a given amount. In the event of a tie, each player receives an identical fraction of the winning prize. Thus players engage in two margins of competition: losing versus tying, and tying versus winning. Two pertinent parameters are the margin required for victory and the value of tying relative to winning. We fully characterize the set of Nash equilibria for the entire parameter space. For much of the parameter space, there is a unique Nash equilibrium which is …

Probing Quantumness With Joint Continuous Measurements Of Non-Commuting Observables, Luis Pedro García-Pintos, Justin Dressel

Mathematics, Physics, and Computer Science Faculty Articles and Research

We analyze the continuous measurement of two noncommuting observables for a qubit, and investigate whether the simultaneously observed noisy signals are consistent with the evolution of an equivalent classical system. Following the approach outlined by Leggett and Garg, we show that the readouts violate macrorealistic inequalities for arbitrarily short temporal correlations. Moreover, the derived inequalities are manifestly violated even in the absence of Hamiltonian evolution, unlike for Leggett-Garg inequalities that use a single continuous measurement. Such a violation should indicate the failure of at least one postulate of macrorealism: either physical quantities do not have well-defined values at all times …

Can Functional Traits Predict Plant Community Response To Global Change?, Sarah Kimball, Jennifer L. Funk, Marko J. Spasojevic, Katharine N. Suding, Scot Parker, Michael K. Goulden

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

One primary goal at the intersection of community ecology and global change biology is to identify functional traits that are useful for predicting plant community response to global change. We used observations of community composition from a long-term field experiment in two adjacent plant communities (grassland and coastal sage shrub) to investigate how nine key plant functional traits were related to altered water and nitrogen availability following fire. We asked whether the functional responses of species found in more than one community type were context dependent and whether community-weighted mean and functional diversity were significantly altered by water and nitrogen …

Can Functional Traits Predict Plant Community Response To Global Change?, Sarah Kimball, Jennifer L. Funk, Marko J. Spasojevic, Katharine N. Suding, Scot Parker, Michael K. Goulden

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

One primary goal at the intersection of community ecology and global change biology is to identify functional traits that are useful for predicting plant community response to global change. We used observations of community composition from a long-term field experiment in two adjacent plant communities (grassland and coastal sage shrub) to investigate how nine key plant functional traits were related to altered water and nitrogen availability following fire. We asked whether the functional responses of species found in more than one community type were context dependent and whether community-weighted mean and functional diversity were significantly altered by water and nitrogen …

A Bounded Affinity Theory Of Religion And The Paranormal, Joseph O. Baker, Christoper Bader, F. Carson Mencken

Sociology Faculty Articles and Research

We outline a theory of bounded affinity between religious experiences and beliefs and paranormalism, which emphasizes that religious and paranormal experiences and beliefs share inherent physiological, psychological, and ontological similarities. Despite these parallels, organized religious groups typically delineate a narrow subset of experiences and explanatory frames as acceptable and True, banishing others as either false or demonic. Accordingly, the theory provides a revised definition of the “paranormal” as beliefs and experiences explicitly rejected by science and organized religions. To demonstrate the utility of the theory, we show that, after controlling for levels of conventional religious practice, there is a strong, …

Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 …

Advances And Perspectives In Genetics Of Congenital Thyroid Disorders Associated With Thyroglobulin Gene Mutations, Héctor M. Targovnik, Cintia E. Citterio, Sofi Siffo, Carina M. Rivolta

Pharmacy Faculty Articles and Research

Dyshormonogenesis due to thyroglobulin (TG) gene mutations is a rare cause of congenital hypothyroidism with an estimated incidence of approximately 1 in 100,000 newborns. The TG gene is organized in 48 exons, spanning over 270 kb on human chromosome 8q24. The human TG mRNA is 8.5 Kb long and the preprotein monomer is composed of a 19 amino acids signal peptide followed by a 2749 residues polypeptide. Until now, one hundred seventeen deleterious mutations in the human TG gene have been identified and characterized, originating structural changes in the protein that alter the normal protein folding, assembly and …

Comparison Of Outcomes Following A Switch From A Brand To An Authorized Vs. Independent Generic Drug, Richard Hansen, Jingjing Qian, Richard L. Berg, James G. Linneman, Enrique Seoane-Vazquez, Sarah Dutcher, Saeid Raofi, C. David Page, Peggy L. Peissig

Pharmacy Faculty Articles and Research

Authorized generics are identical in formulation to brand drugs, manufactured by the brand company but marketed as a generic. Generics, marketed by generic manufacturers, are required to demonstrate pharmaceutical and bioequivalence to the brand drug, but repetition of clinical trials is not required. This retrospective cohort study compared outcomes for generics and authorized generics, which serves as a generic vs. brand proxy that minimizes bias against generics. For the seven drugs studied between 1999-2014, 5,234 unique patients were on brand drug prior to generic entry and 4,900 (93.6%) switched to a generic. During the 12-months following the brand-to-generic switch, patients …

A Perspective On Electronic Alternatives To Traditional Currencies, Gabriele Camera

ESI Working Papers

The institution of money is rapidly evolving thanks to developments in computer-based cryptography. Technological advances have made possible the creation of cost-effective electronic alternatives to banknotes and coins, which are the traditional physical currencies. This document aims to describe — based on scientific literature — the use and characteristics of money, some of the problems associated with issuing a new currency or a new payment instrument, and the possible comparative advantages of a central bank in leading the way relative to private issuers.

Stability Of Peatland Carbon To Rising Temperatures, R. M. Wilson, A. M. Hopple, M. M. Tfaily, S. D. Sebestyen, C. W. Schadt, L. Pfeifer-Meister, Cassandra Medvedeff, K. J. Mcfarlane, J. E. Kostka, M. Kolton, R. K. Kolka, L. A. Kluber, Jason K. Keller, T. P. Guilderson, N. A. Griffiths, J. P. Chanton, S. D. Brigham, P. J. Hanson

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Peatlands contain one-third of soil carbon (C), mostly buried in deep, saturated anoxic zones (catotelm). The response of catotelm C to climate forcing is uncertain, because prior experiments have focused on surface warming. We show that deep peat heating of a 2 m-thick peat column results in an exponential increase in CH4 emissions. However, this response is due solely to surface processes and not degradation of catotelm peat. Incubations show that only the top 20–30 cm of peat from experimental plots have higher CH4 production rates at elevated temperatures. Radiocarbon analyses demonstrate that CH4 and CO2 are produced primarily from …

“All Museums Will Become Department Stores”: The Development And Implications Of Retailing At Museums And Heritage Sites, Jamie Larkin

Art Faculty Articles and Research

Museums and heritage sites have provided merchandise for visitors to purchase since their earliest incarnations as public attractions in the 18th century. Despite this longevity scant academic research has been directed towards such activities. However, retailing – formalised in the emergence of the museum shop – offers insights into a range of issues, from cultural representation and education, to eco- nomic sustainability. This paper outlines the historical development of retailing at museums and heritage sites in the UK, before offering a summary of current issues, illustrated by a case study of contemporary retailing at Whitby Abbey. The paper demonstrates how …

Synthesis Of Rhamnosylated Arginine Glycopeptides And Determination Of The Glycosidic Linkage In Bacterial Elongation Factor P, Siyao Wang, Leo Corcilius, Phillip B. Sharp, Andrei Rajkovic, Michael Ibba, Benjamin L. Parker, Richard J. Payne

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A new class of N-linked protein glycosylation – arginine rhamnosylation – has recently been discovered as a critical modification for the function of bacterial elongation factor P (EF-P). Herein, we describe the synthesis of suitably protected α- and β-rhamnosylated arginine amino acid “cassettes” that can be directly installed into rhamnosylated peptides. Preparation of a proteolytic fragment of Pseudomonas aeruginosa EF-P bearing both α- and β-rhamnosylated arginine enabled the unequivocal determination of the native glycosidic linkage to be α through 2D NMR and nano-UHPLC-tandem mass spectrometry studies.

Asymmetric Social Norms, Gabriele Camera, Alessandro Gioffré

ESI Working Papers

Studies of cooperation in infinitely repeated matching games focus on homogeneous economies, where full cooperation is efficient and any defection is collectively sanctioned. Here we study heterogeneous economies where occasional defections are part of efficient play, and show how to support those outcomes through contagious punishments.

Sea Surface Temperature Rises Shift Migration Patterns Due To Ecosystem Changes, Alexia Skrbic, Hesham El-Askary

Student Scholar Symposium Abstracts and Posters

The continuing climate change is negatively impacting ecosystems, specifically oceans which are declining and food webs are being altered by the increase of greenhouse gases. The increase of the carbon dioxide and other greenhouse gases is increasing sea surface temperature of the world’s oceans. Certain organisms lower on the food chain like phytoplankton and zooplankton are directly affected by the warming which alters how they process nutrients and their productivity. The limited amount of these primary producers in the oceans and specifically the location they inhabit directly affects all the organisms above them on the food chain. Several marine animals …

Manual And Automated Solid Phase Synthesis Of Peptides For Breast Cancer Cell Targeting, Savannah Carlson

Student Scholar Symposium Abstracts and Posters

Four peptides were synthesized using solid phase peptide synthesis. The two target peptides synthesized were based off peptide 18-4 and its negative analog. Each were synthesized once manually, and once using an automatic peptide synthesizer. Peptide 18-4 has a high affinity for breast cancer cells, allowing it to be used to detect circulating tumor cells (CTCs) in blood (Kaur et. al, 2015). Manual solid phase peptide synthesis is performed by anchoring the first amino acid to Wang resin and coupling each Fmoc protected amino acid individually until the target sequence is achieved. To synthesize the peptides automatically, the automated Tribute …

Student Pianists In Recital, Aaron Grisez, Rachel Gossen, Ariel Chien, Niki Black, Rebekah Dennis, Madeline Barrett, Lewis Gehami, Yusuke Sumoyama, Avery Roberts, Mai Phuong Duong, Dylan Kanner, Ashley Shahbazi, Michael Seaman

Printed Performance Programs (PDF Format)

No abstract provided.

Contributing Factors To Perspectives On Gun Regulations, Syd Kotar

Student Scholar Symposium Abstracts and Posters

With a rising amount of gun violence, issues of stricter gun regulations have been brought to the government’s attention. Location, gender, and ideology all contribute to how one perceives the individual use of firearms, and believes how much the government should intervene. This paper will explore the different variables such as the three listed above that affect one’s opinions on government intervention concerning stricter gun regulations. The results of data analysis from the ANES 2012 studies conclude that the more conservative one self identifies as, one would want either the same or less government intervention concerning stricter gun regulations. Data …

The Authentic Workplace: Theatrical Practices In The Corporate World, Katherine Dumas

Student Scholar Symposium Abstracts and Posters

"We are beginning to bring our whole selves to work… That type of separation probably never existed… Instead of putting on some kind of fake “all-work persona,” I think we benefit from expressing our truth, talking about personal situations, and acknowledging that professional decisions are emotionally driven."(1) In her award-winning 2013 book Lean In: Women, Work, and the Will to Lead, Sheryl Sandberg explains the movement in the corporate world to look for emotional intelligence in potential employees before they are hired. Qualities such as this are nurtured and practiced regularly in the world of theatre, as evidenced by the …

Has The American Electorate Changed Its Concept Of An Ideal President? Candidate Traits And Their Impact On Voter Favorability, Bennett Tuleja

Student Scholar Symposium Abstracts and Posters

Psychology research has exemplified that leadership is revered largely by society as a masculine characteristic. It is not surprising to find that past studies surrounding the issue of what characteristics the American people look for in a Presidential candidate find that more masculine characteristics, in particular strong leadership qualities, have an impact on how Americans perceive presidential candidates and utilize those perceptions when casting their vote. However, in the ever changing political landscape of the United States, especially given the furthering of women in politics, these masculine tides are seemingly bound to change. Hillary Clinton, for instance, embodies this change …

Linear Feedback Stabilization For A Continuously Monitored Qubit, Taylor Lee Patti, A. Chantasri, Justin Dressel, A. N. Jordan

Student Scholar Symposium Abstracts and Posters

In quantum mechanics, standard or strong measurement approaches generally result in the collapse of an ensemble of wavefunctions into a stochastic mixture of eigenstates. On the other hand, continuous or weak measurements have the propensity to dynamically control the evolution of quantum states over time, guiding the trajectory of the state into non-trivial superpositions and maintaining state purity. This kind of measurement-induced state steering is of great theoretical and experimental interest for the harnessing of quantum bits or "qubits", which are the fundamental unit of the emerging quantum computer. We explore continuous measurement-based quantum state stabilization through linear feedback control …

Maurice's Love, Peggy Wood

Student Scholar Symposium Abstracts and Posters

“By linking their love to the past he linked it to the present” (Forster 745).

E. M. Forster’s Maurice is a widely read and taught text that features homosexuality in Edwardian England. The focus of this thesis is an in-depth analysis of Maurice’s character, with a specific emphasis on the character’s coming out process. The coming out process is still a significant issue in today’s world. Hate crimes, ostracism, and many other negatives can be associated with the coming out process that is not entirely different from what Maurice Hall faced. This statement is easily supported by historical accounts and …

American Voter Attitudes Towards Divided Government, Tyler Ferrari

Student Scholar Symposium Abstracts and Posters

Divided government has been a major part of American politics for decades, and it has made governing often difficult at times. Recently, this type of government has proven to be especially frustrating for many voters, so why do they vote to keep this government? Are there partisan reasons for voting for a split ticket, or is the answer more fundamental? This paper highlights the facts and reasons for polarization, ranging from ideology to trust in the federal government as a whole. This paper utilizes the ANES 2012 Study to illustrate that it is not just political ideology that plays a …

African American Culture In Historical Art Museums: Remembering A Buried Tragic Past, Lana Sarkisian

Student Scholar Symposium Abstracts and Posters

The transparency of reality reflecting in art often represents a false tragedy in African American history because of the lack of preservation and representation due to a predominantly white dominion, ultimately leaving the veracity of their history to consign to oblivion. There is a common thread of forgetfulness with the retrieval of art in today’s society that embodies the African American community. Although artist Fred Wilson does not explicitly assert his assessment to the lack of black representation on account of cultural differences, he vocalizes how African American culture is indoctrinated to the public in a white, supremacist national narrative …

Just Another After-School Program? A Cross-Sectional Look At Whether Access To Educational Resources And Mentorship Via Casa De Amistad Improves Students' Academic Outcomes In The San Dieguito School District, Katie Page

Student Scholar Symposium Abstracts and Posters

Since beginning in 1997, Casa de Amistad’s academic mentoring program has grown from serving three students on its first night to over 230 undeserved children, teens and their parents annually. Students participating in Casa de Amistad (Casa) are from school districts throughout coastal North County San Diego. In the past 16 years, teachers in the district have noticed an increase in homework completion and classroom participation, as well as an improvement in grades and test scores among students who participated in Casa. This study was designed to further research the performance and needs of Casa de Amistad’s students in an …

Hnrnpa2 Is A Novel Histone Acetyltransferase That Mediates Mitochondrial Stress-Induced Nuclear Gene Expression, Manti Guha, Satish Srinivasan, Kip Guja, Edison Mejia, Miguel Garcia-Diaz, F. Brad Johnson, Gordon Ruthel, Brett A. Kaufman, Eric F. Rappaport, M. Rebecca Glineburg, Ji-Kang Fang, Andres J. Klein-Szanto, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G. Avadhani

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Reduced mitochondrial DNA copy number, mitochondrial DNA mutations or disruption of electron transfer chain complexes induce mitochondria-to-nucleus retrograde signaling, which induces global change in nuclear gene expression ultimately contributing to various human pathologies including cancer. Recent studies suggest that these mitochondrial changes cause transcriptional reprogramming of nuclear genes although the mechanism of this cross talk remains unclear. Here, we provide evidence that mitochondria-to-nucleus retrograde signaling regulates chromatin acetylation and alters nuclear gene expression through the heterogeneous ribonucleoprotein A2 (hnRNAP2). These processes are reversed when mitochondrial DNA content is restored to near normal cell levels. We show that the mitochondrial stress-induced …

Instrumental Chamber Music: Strings, Emy Eddow, Sam Naff, Amadea Tanner, Charley Story, Alicia Correa, Julianne Lussier, Ariel Chien, Katie Kotar, Arturo Balmaceda, Chris Noble, Hannah Ceriani, Lorianne Frelly, Lisa Yoshida, Safieh Moshir-Fatemi, Preston Yamasaki, Haley Hedegard, Will Parker, Ryan Kelly, Isabella Pepke, Stella Monshaw, Eileen Kim, Chris Nelson, Clio Brady

Printed Performance Programs (PDF Format)

No abstract provided.

Formulating A Pharmacy Collection Without A Prescription, Kristin Laughtin-Dunker, Linda Galloway

Library Articles and Research

Librarians without a background in the health sciences were tasked with building a collection to support a new pharmacy school at a traditionally liberal arts institution. Despite little subject expertise, the team assessed current holdings, conducted a review of recommended resources, and collaborated with faculty to prioritize acquisitions to support the developing program as funds became available. The hire of a health sciences librarian provided new opportunities for assessment and for continued collecting. Altogether, this process allowed for the creation of recommended best practices that can be adopted by any librarian procuring resources to support new health science programs.