Digital Commons Network^™

Discovery Of Ro 41-0960, A Non-Steroidal Inhibitor Of The Na+/K+-Atpase, Carlos Cruz-Cortés, Jaroslava Šeflová, Guadalupe Guerrero-Serna, Eric N. Jimenez-Vazquez

Health & Biomedical Sciences Faculty Publications

The Na⁺/K⁺-ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure. Yet, cardiotonic steroids used in clinical practice are limited by a narrow therapeutic window and pro-arrhythmic effects. Here, we identify Ro 41-0960 as a non-steroidal inhibitor of NKA with a distinct mechanistic profile. The compound inhibits NKA activity with IC50 values of 17.9 ± 1.1 µM for purified enzyme and https://doi.org/10.3 ± 1.1 µM in microsomal preparations. ATP-dependent activity measurements revealed a non-monotonic response in which inhibition was most pronounced at ATP concentrations below 4 mM and diminished …

Norman H. Cromwell, Unl Chemistry; Nu System Dean; Eppley Cancer Center Director, Norman H. Cromwell, Pete Boughn, Mark A. Griep

UNL ORCA Interview Series

This 1980 interview of Normal Cromwell was done by Pete Boughn at the University of Nebraska Medical Center in Omaha. He asked about Cromwell’s history but mostly about his time as director of the Eppley Cancer Center. The interview is reproduced with permission from the UNMC McGoogan Library.

Cromwell was born in 1913 in Terre Haute, Indiana. In 1935, he earned a bachelor’s degree in chemical engineering from the Rose-Hulman Institute of Technology in his hometown. In 1939, three things happened: he earned a doctorate in organic chemistry from the University of Minnesota, he got married, and he was hired …

Identification Of Active Compounds And Antidiabetic Activity Of Red Shoot (Syzygium Myrtifolium) Leaves Extract With In Vitro And In Silico Methods, Muhamad Iqbal Prakoso, Siti Warnasih

Pharmaceutical Sciences and Research

Diabetes mellitus (DM) is a chronic metabolic disease that affects approximately 537 million people worldwide (1 in 10 individuals), and its prevalence is projected to reach 783 million by 2045. One of the plants that has the potential to be an antidiabetic is red shoots (Syzygium myrtifolium) since it contains various secondary metabolite compounds such as flavonoids, triterpenoids, steroids, saponins, phenolics, and anthocyanins. This study aimed to evaluate the antidiabetic properties of red shoot leaves extract and to identify and predict interactions between its active compounds and the α-glucosidase receptor. Ethanol, ethyl acetate, and n-hexane extracts of red …

Medical Staff Journal, 1991, V1 N2, Spring, Advocate Health - Midwest

Historical Documents - Combined

Lutheran General Hospital, Park Ridge, IL: Quarterly publication produced by and for medical staff at Lutheran General Hospital. This issue includes case studies, professional activities, and a directory of new staff members.

Comparative Case Studies Of How General Chemistry Ii Students Explain Entropically-Driven Phenomena, Raymundo Aragonez

Open Access Theses & Dissertations

Understanding how students conceptualize entropy remains a central challenge in chemistry education. Often referred to as a "driving force" of chemical reactions, the dispersal of energy as a process proceeds is indicative of a process's spontaneity or thermodynamic favorability. Students frequently default to discussing phenomena in deterministic terms, potentially reflecting the language choice and heuristics selected by the instructor such as "disorder". In this study, assessment prompts about entropy from a convenience sample of general chemistry textbooks were characterized as to their potential to elicit three-dimensional learning, and students' responses to assessment prompts from a curriculum aligned with three-dimensional learning …

A Challenging Presentation Of Mycoplasma Pneumoniae: Mild Hepatic Dysfunction With Persistent Leukocytosis In A Pediatric Patient, Robert J. Heins, Sierra Scott, Stephen Mock

Student Publications

Mycoplasma pneumoniae (MP) is a common pediatric respiratory pathogen that can rarely present with extrapulmonary manifestations such as hepatic involvement. Recognition of hepatic dysfunction in this context is important for accurate diagnosis and timely therapy. A five-year-old female with asthma presented with fever, cough, fatigue, pruritus, and scleral icterus. Laboratory evaluation revealed leukocytosis, elevated C-reactive protein, mild transaminitis, direct hyperbilirubinemia, elevated PT/PTT, and normocytic anemia. Infectious and hepatic workups were initially unrevealing. The patient showed gradual clinical improvement while receiving empiric ceftriaxone but had persistent leukocytosis. On hospital Day 7, a positive MP IgM prompted azithromycin initiation, which corresponded to …

Interfacial Chemistry Involved In Selective Separation Of Nmc/Lmo And Lco/Lmo Binary Cathode Materials By Froth Flotation Using Oleic Acid, Richard Kofi Oboh, Kaiwu Huang, Seoung Bum Son, Lei Pan

Michigan Tech Publications

The variability in cathode compositions within recycled lithium-ion battery (LIB) feedstocks poses a significant challenge to efficient downstream refining processes. This study demonstrates the feasibility of using froth flotation with oleic acid as a collector to selectively separate lithium nickel-manganese-cobalt oxide (NMC) and lithium cobalt oxide (LCO) from lithium manganese oxide (LMO) materials. Laboratory-scale flotation tests achieved an 80% separation efficiency in a single stage, producing a froth product with >90% purity of NMC/LCO at approximately 90% yield. Concurrently, the LMO materials were enriched in the sink product with ∼90% purity and ∼90% yield. This approach was further validated using …

Long-Term Variability Of Air Quality And Greenhouse Gas Emissions From Rice Crop Burning In Punjab During 2012–2020, Harsimranjit Kaur Romana, Dericks Praise Shukla, Ramesh P. Singh

Mathematics, Physics, and Computer Science Faculty Articles and Research

Punjab, India's primary rice and wheat production hub, has witnessed rapid expansion of paddy cultivation over the past two decades, driven by minimum support price incentives, changes in government policies, alignment of sowing with the monsoon season and the adoption of high-yielding varieties. This transition has intensified groundwater extraction and shortened the fallow period between rabi and kharif crop seasons, reducing the window between rice harvesting and wheat sowing, leading to widespread open-field burning of rice residue and recurrent post-monsoon air-quality deterioration across the Indo-Gangetic Plain. Despite numerous short-term or single-pollutant assessments, a spatially resolved, multi-pollutant and multi-decadal evaluation linking …

Effect Of Mxene Ti3c2 On The Pvdf Ultrafiltration Membrane Properties And Performance, Tamara Abood, Kadium Shabeeb, Aseel Alzubaydi, Qusay Alsalhy, Pei Goh, Ahmad Ismail, Adel Zrelli

Engineering and Technology Journal

The problem of membrane fouling remains a significant concern in ultrafiltration, a commonly employed method in water treatment due to its high efficacy and minimal energy consumption. This study made a nanocomposite ultrafiltration membrane out of MXene Ti3C2 nanosheets, a new two-dimensional material, to improve the antifouling properties of PVDF membranes. It was possible to incorporate the nanosheets into the membrane structure through in situ embedment during the phase inversion process. To learn more about them, the study investigated the membranes using FESEM, FTIR, water contact angle (CA), and porosity measurements. The application of common flux and rejection tests assessed …

Provost’S Scholarly Dissemination Report: Une Authored Publications November 1, 2025, Through January 31, 2026, Une Office Of The Provost, Sonya Durney

UNE Provost's Reports

Scholarly dissemination report of UNE-authored publications during the period of November 1, 2025, through January 31, 2026. Prepared for the Academic, Student, and Research Affairs Committee Provost’s Report, March 2026.

Effects Of Varying Ph, Temperature, And Sucrose Concentration On The Activity Of Invertase Enzyme, B. Rainwater, S. Pratihar

Journal of the Arkansas Academy of Science

The purpose of this research is to study the factors that affect the enzymatic activity of invertase, extracted from baker’s yeast, on hydrolysis of sucrose in aqueous medium. Invertase, a glycoprotein, is an enzyme in the glycoside hydrolase family. It catalyzes the hydrolysis of sucrose producing equimolar mixture of a-D-glucose and b-D-fructose. Invertase shows high affinity for the substrate, and is capable of both cleaving the glycosidic linkage in sucrose and transferring ab-D-O-fructofuranoside residue to an acceptor substrate. (Toledo et al. 2019). A detailed mechanism of the action of invertase was postulated by Shall et al. (Shall et al. 1971). …

Review Of Research Conducted In Rocky Mountain National Park And The Tatra National Parks On Poland And Slovakia, William Bowman, Ben Bobwski

Rocky Mountain National Park

Research on Rocky Mountain National Park and the park's interactions with Tatra National Park.

Churchill, Amber; Bowman, William; Institute of Alpine, Anarchic, and Arctic Research; Department of Ecology and Evolutional Biology; University of Colorado Boulder;

Assessing The Application Of Optical-Photothermal Infrared Spectroscopy For Single-Grain Chemical Palynology, Laura Scoble, Hao Meng, Simon J. Ussher, Mark F. Fitzsimons, Lauren Ansell, Mustafa Kansiz, Billy Simmonds, Nick Stone, Ralph M. Fyfe

School of Geography, Earth and Environmental Sciences

Single-grain pollen analysis is essential for advancing chemical palynology, which classifies morphologically similar taxa based on taxon-specific pollen and sporopollenin chemistry. Fourier-Transform Infrared (FT-IR) spectroscopy and microspectroscopy (μFT-IR) are widely used to differentiate morphologically similar grains but face limitations from Mie scattering and coarse spatial resolution. Here, we present the first application of Optical-PhotoThermal Infrared (O-PTIR) spectroscopy to chemically treated single pollen grains, using Molinia caerulea as a model taxon to fully test and evaluate the technical capabilities and limitations of this technique. O-PTIR achieves sub-micron “super-resolution” infrared spectroscopy through non-contact, non-destructive measurements by exploiting the photothermal effect. O-PTIR spectra …

Expectations In The Preservation Of Dna And Bacterial Organisms In Differential Montana Burials, Kaylee M. Hinds

Graduate Student Theses, Dissertations, & Professional Papers

This study investigates patterns of decomposition and biomolecular preservation in domestic pig (Sus scrofa domesticus) proxies under varying burial conditions in a cold, seasonal climate. Conducted at the Lubrecht Experimental Forest in western Montana, the project aims to evaluate DNA degradation, microbial activity, and environmental influences across shallow, deep, surface, and secondary burial contexts. Three pigs were placed in distinct burial treatments (surface exposure, partial burial, and full burial), with a fourth site later added following bear disturbance and carcass relocation. Environmental monitoring included temperature, and soil sampling before and throughout the decomposition process. Systematic sampling of bone, soft tissue, …

Ai & Chemistry, Evelina Jaleniauskiene

Teaching Repository of AI-Infused Learning

"AI & Chemistry" is a four-week language-learning project based on the action-oriented approach. The project asks students to complete two main tasks: prepare an individual Ignite talk and a partnered podcast on any subtopic related to the use of AI in chemistry. Beyond language skills, the project additionally aims to encourage students’ collaboration with AI-powered tools and enhance their AI literacy. All project steps are detailed in an additional PDF file. The integration of the project is not restricted to a language course; it can be adapted for any university-level communicative course.

2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Sustained Response To Pan-Braf Inhibitor Plixorafenib (Fore8394, Plx8394) In A Young Adult With Neurodegenerative Langerhans Cell Histiocytosis, Joanna S Yi, Kathleen S Mccarthy, Kate Mazur, Rebecca Kudlaty, Terry Armstrong, Nilesh Desai, Stacie Peacock Shepherd, Daniel Zinn, Jessica Velazquez, Brooks Scull, Carl Allen, Kenneth Mcclain

Faculty, Staff and Students Publications

No abstract provided.

Synthesis, Structure-Activity Relationships, And Antitumor Activities Of Quinoxiline-Containing Inhibitors Of The Protein-Protein Interactions Between Transcription Coactivator Af9/Enl And Dot1l/Af4, Chandra Bhushan Mishra, Xin Li, Bala Krishna Moku, Sehun Kwak, Dnyaneshwar N Garad, Yongcheng Song

Faculty, Staff and Students Publications

Mixed lineage leukemia (MLL) gene rearrangements cause ~75% of acute leukemia in infants and 5-10% in children and adults with poor clinical outcomes. Protein-protein interactions (PPI) between frequent MLL fusion partners AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rearranged (MLL-r) leukemia. Sixty-seven quinoxiline compounds were synthesized and tested for their ability to inhibit such PPIs. Compounds 16, 17, 59 and 63 were found to be potent inhibitors with IC50 values of 0.35-1.5 μM. Structure-activity relationships are discussed. Potent inhibitors can suppress expression of MLL target genes Myc and Meis1 and selectively block proliferation of MLL-r and …

Proceedings Of The 2025 Berry Summer Thesis Institute, University Of Dayton. University Honors Program, Dorian Borbonus, Nicholas J. Canfield, Triet M. Cao, Thomas Crossman, Jeffrey Huettemann, Aung Myat Khaung, Chase Kinder, Elizabeth Krahe, Anh Duc Nguyen, Quynh Anh Nguyen, Anna M. Petre, Kayden G. Rothery, Anna M. Schmitz, Rachel Zeller

Proceedings of the Berry Summer Thesis Institute (2013-Present)

Thanks to a gift from the Berry Family Foundation and the Berry family, the University Honors Program launched the Berry Summer Thesis Institute in 2012. The institute introduces students in the University Honors Program to intensive research, scholarship opportunities and professional development. Each student pursues a 12-week summer thesis research project under the guidance of a UD faculty mentor. This contains the product of the students' research.

Simulating Chemiluminescence Spectra Of Oh Radical Using Quantum Dynamical Simulations, Triet M. Cao

Research from the Berry Summer Thesis Institute, 2025

Chemiluminescence is a phenomenon of light emission that occurs when molecules transition from an excited state to the ground state. This phenomenon is widely utilized in applications ranging from quantifying product yields in chemical reactions to biological imaging and atmospheric chemistry studies. It has also been used in many crucial applications in the scarce conditions of heat and electricity, such as light sources for astronomy discovery or deep-sea diving. A notable example of such reactions is combustion, where highly reactive hydroxyl radicals (OH) are products. These radicals exhibit a chemiluminescence spectrum because of the interaction between their ground state and …

Designing A Data Collection And Visualization Toolkit For Scalable Tensor Algebra In Quantum Chemistry Applications, Epiya J. Ebiapia

LSU Master's Theses

Large-scale quantum chemistry computations, such as those executed with the Tensor Algebra for Many-body Methods (TAMM) framework, require careful configuration of runtime parameters to achieve high performance and cost efficiency in high-performance computing (HPC) and cloud environments. Without effective performance analysis tools, researchers risk inefficient use of computational resources, leading to longer runtimes and higher costs.

To address this challenge, this thesis presents the design and implementation of a performance profiling and visualization toolkit for TAMM, developed as part of the DOE TEC4 project in collaboration with Pacific Northwest National Laboratory, Microsoft, and Louisiana State University. The toolkit collects detailed …

Insights Into The Radiation Chemistry Of Flash Radiation Therapy, Alan E. Lopez Hernandez

Dissertations and Theses (Open Access)

Purpose: FLASH radiation therapy (FLASH-RT) is an emerging modality that delivers radiation at ultra-high dose rates (UHDR) and has shown consistent normal tissue sparing while preserving tumor control compared to conventional RT—a phenomenon termed the FLASH effect. Despite promising results, the mechanisms behind the FLASH effect remain unclear. Many hypotheses point to radiolytic interactions, but experimental validation is limited. This work aims to develop a robust experimental platform to evaluate the relationship between radiolytic species production and physical beam parameters relevant to FLASH-RT, alongside dosimetry tools for reliable UHDR beam characterization.

Methods: A beam collector (BC) Faraday cup detector was …

Vacuum Consistent Electrochemistry In Ionic Liquid Combined With Oxide Epitaxy, Yuji Matsumoto

Journal of Electrochemistry

We introduce our state-of-the art of “vacuum consistent electrochemistry” to an investigation of the interfaces between oxides and ionic liquid (IL). Pulsed laser deposition (PLD) has been one of the powerful and sophisticated techniques to realize nanoscale preparation of high-quality epitaxial oxide thin films. On the other hand, electrochemistry is a simple, very sensitive, and non-destructive analysis technique for solid-liquid interfaces. To ensure the reproducibility in experiment of the interfaces of such epitaxial oxide films, as well as bulk oxide single-crystals, with IL, we employ a home-built PLD-electrochemical (EC) system with IL as an electrolyte. The system allows one to …

Shallow Water Table In Arid Urban Zone: Preliminary Study At Sultan Qaboos University Campus, Oman, Ali Al-Maktoumi

Journal of Agricultural and Marine Sciences

A shallow water table (SWT) rises up to several centimeters below the soil surface and even exfiltrates making surface impoundments that are common in humid climates. Recently, SWTs emerged even in arid and semi-arid regions of several metropolitan areas of the Arabian Gulf Cooperation Council (GCC) countries with a pernicious impact on the urban infrastructure, health, ecohydrology of parks and gardens, among others. Quantifying SWT’s dynamics and understanding the associated phenomena of water motion and solute transport are vital for finding the proper mitigation techniques and reducing the risks associated with SWT. In this preliminary study, SWT was delineated, its …

Illuminated Magazine - Spring 2025, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

• 2: Editorial Staff
• 6: Betting on Appalachia: How Appalachian Identity Correlates to Gambling Disorder; Noah Anderson, Psychology, PhD
• 9: Where Are They Now? Featuring Maria Jose Araujo Dias
• 10: Inner Bonds: An Exploration of Emotions through Character Creation, Story, and Design; Cait Maltbie, Studio Art, MFA
• 13: Where Are They Now? Featuring Cynthia Milhorn
• 14: Characterizing the Polymicrobial Interactions of Alcaligenes faecalis; Aly Hargrave, Biology, MS
• 18: Grant Award Recipients
• 20: Discovering a Potentially Novel Bacteriocin from Klebsiella Bacteria; Jasmal Cruz Perez, Biology, MS
• 23: Where Are They Now? Featuring Julianne Hensley
• 24: Assessing How Different Training Programs Affect High-Intensity …

Next-Generation Biomedical Implants And Stimuli Responsive Soft Optical Arrays Via Surface Functionalized Elastomeric Materials, John M. Kapitan

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The demands of emerging technologies, such as soft robotics, stretchable electronics, and next generation biomedical implants, has led to the development of diverse polymeric and hybrid organic/inorganic materials specifically tuned to meet these challenges. These materials typically have low Young’s moduli and are inert with high chemical stability. However, this has led to materials that are static in nature, lacking any meaningful way of responding to changes in their environment and adapting to these changes. This has driven a shift towards the design, manufacturing, and characterization of various stimuli responsive surfaces, relying on precise control of surface chemical coatings and …

Postseismic Groundwater Quality Investigation In Aquifers Following Earthquake-Induced Demolition Wastes: Hatay (Türkiye) Case Study, Pinar Avci, Gali̇p Yüce

Turkish Journal of Earth Sciences

The February 6, 2023 seismic sequence that hit, the Antakya district of Hatay (Türkiye), killed more than 50,000 people and caused extensive structural damages, resulting in the collapse of 80% of the building stock that generated over 100 million tons of debris. Understanding the impact of seismic events on water resources is highly important for ensuring human and environmental health. Herewith, a study was carried out over the Hatay area to assess the post-earthquake sustainable usability of groundwater for drinking, domestic, and irrigation purposes. 17 water points were investigated in September 2023, encompassing alluvial deposits with relatively high hydraulic conductivity …

News From The Chapters 1986-1987, C. Nicholas Raphael

The Geographical Bulletin

During the fall the Gamma Delta Chapter held a series of seminars on topics of controversial nature, such as the causes of glaciation and the extinction of the dinosaurs. The fall picnic was a well-attended success as was the Christmas banquet. During the spring term, the chapter is running a seminar on the Great Plains and is co-sponsoring, with Biology's Tri Beta and Geology's SGE, the visit of Carnegie Museum's Leonard Krishtalka, a paleontologist. The annual spring picnic is held in early May.

Modeling Actinic Flux And Photolysis Frequencies In Dense Biomass Burning Plumes, Jan-Lukas Tirpitz, Santo Fedele Colosimo, Nathaniel Brockway, Robert Spurr, Matt Christi, Samuel Hall, Kirk Ullmann, Johnathan Hair, Taylor Shingler, Rodney Weber, Jack E. Dibb, Richard Moore, Elizabeth Wiggins, Vijay Natraj, Nicolas Theys, Jochen Stutz

Faculty Publications

Biomass burning (BB) affects air quality and climate by releasing large quantities of gaseous and particulate pollutants into the atmosphere. Photochemical processing during daylight transforms these emissions, influencing their overall environmental impact. Accurately quantifying the photochemical drivers, namely actinic flux and photolysis frequencies, is crucial to constraining this chemistry. However, the complex radiative transfer within BB plumes presents a significant challenge for both direct observations and numerical models.

This study introduces an expanded version of the 1D VLIDORT-QS radiative transfer (RT) model, named VLIDORT for photochemistry (VPC). VPC is designed for photochemical and remote sensing applications, particularly in BB plumes …

Chem 361-002: Environmental Chemistry Of Wter And Soil Pollution, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.