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Stride-To-Stride Variability Is Altered During Backward Walking In Anterior Cruciate Ligament Deficient Patients, Franceska Zampeli, Constantina Moraiti Moraiti, Sofia Xergia, Vasilios Tsiaras, Nikolaos Stergiou, Anastasios D. Georgoulis

Journal Articles

Background: Recently backward walking is used by physical therapists to strengthen the hamstring muscles and thus improve the function of the knee joint of anterior cruciate ligament deficient patients. The aim of this study was to examine the stride-to-stride variability of anterior cruciate ligament deficient patients during backward walking. The variation of how a motor behavior emerges in time is best captured by tools derived from nonlinear dynamics, for which the temporal sequence in a series of values is the facet of interest.

Methods: Fifteen patients with unilateral anterior cruciate ligament deficiency and eleven healthy controls walked backwards …

The Effect Of Music On Robot-Assisted Laparoscopic Surgical Performance, Ka-Chun Siu, I. H. Suh, Mukul Mukherjee, D. Oleynikov, Nikolaos Stergiou

Journal Articles

Music is often played in the operating room to increase the surgeon’s concentration and to mask noise. It could have a beneficial effect on surgical performance. Ten participants with limited experience with the da Vinci robotic surgical system were recruited to perform two surgical tasks: suture tying and mesh alignment when classical, jazz, hip-hop, and Jamaican music were presented. Kinematics of the instrument tips of the surgical robot and surface electromyography of the subjects were recorded. Results revealed that a significant music effect was found for both tasks with decreased time to task completion (P = .005) and total …

A Comparison Of Interventions For Children With Cerebral Palsy To Improve Sitting Postural Control: A Clinical Trial, Regina T. Harbourne, Sandra L. Willett, Anastasia Kyvelidou, Joan E. Deffeyes, Nikolaos Stergiou

Journal Articles

Background The ability to sit independently is fundamental for function but delayed in infants with cerebral palsy (CP). Studies of interventions directed specifically toward sitting in infants with CP have not been reported.

Objective The purpose of this study was to compare 2 interventions for improving sitting postural control in infants with CP.

Design For this randomized longitudinal study, infants under 2 years of age and at risk for CP were recruited for intervention directed toward sitting independence.

Setting The intervention was conducted at home or at an outpatient facility.

Patients and Intervention Fifteen infants with typical development (mean age …

A Disposition To Reappraise Decreases Anterior Insula Reactivity During Anxious Anticipation, Joshua M. Carlson, Lilianne R. Mujica-Parodi

Journal Articles

No abstract provided.

Chronic Spontaneous Activity Generated In The Somata Of Primary Nociceptors Is Associated With Pain-Related Behavior After Spinal Cord Injury, Supinder S Bedi, Qing Yang, Robyn J Crook, Junhui Du, Zizhen Wu, Harvey M Fishman, Raymond J Grill, Susan M Carlton, Edgar T Walters

Journal Articles

Mechanisms underlying chronic pain that develops after spinal cord injury (SCI) are incompletely understood. Most research on SCI pain mechanisms has focused on neuronal alterations within pain pathways at spinal and supraspinal levels associated with inflammation and glial activation. These events might also impact central processes of primary sensory neurons, triggering in nociceptors a hyperexcitable state and spontaneous activity (SA) that drive behavioral hypersensitivity and pain. SCI can sensitize peripheral fibers of nociceptors and promote peripheral SA, but whether these effects are driven by extrinsic alterations in surrounding tissue or are intrinsic to the nociceptor, and whether similar SA occurs …

Gait Variability Patterns Are Altered In Healthy Young Individuals During The Acute Reperfusion Phase Of Ischemia-Reperfusion, Sara A. Myers, Nikolaos Stergiou, Iraklis Pipinos, Jason Johanning

Journal Articles

Background

The role of ischemia reperfusion contributing to functional impairment in lower extremity peripheral arterial disease (PAD) patients has not previously been elucidated. The evaluation of gait variability patterns has proven useful in many pathologic populations. Therefore, the purpose of this study is to isolate and determine the specific effect of the acute reperfusion phase of ischemia-reperfusion on gait variability in young individuals with no vascular disease.

Materials and Methods

Thirty healthy young individuals walked on a treadmill during baseline and the acute reperfusion phase of ischemia-reperfusion conditions while lower extremity joint kinematics were captured. Stride to stride variability was …

Acl Reconstructed Patients With A Bptb Graft Present An Impaired Vastus Lateralis Neuromuscular Response During High Intensity Running, Kostas Patras, Giorgos Ziogas, Stavros Ristanis, Elias Tsepis, Nikolaos Stergiou, Anastasios D. Georgoulis

Journal Articles

The purpose of the present study was to investigate whether the electromyographic response of the vastus lateralis (VL) muscle in the anterior cruciate ligament (ACL) reconstructed leg is similar to that of the intact contralateral leg and healthy controls, during moderate and high intensity running. Fourteen bone–patellar tendon–bone (BPTB) ACL reconstructed amateur soccer players and fourteen healthy control amateur soccer players volunteered to participate in the study. Electromyographic (EMG) traces from the vastus lateralis (VL) muscle were collected bilaterally, as athletes ran on a treadmill for 10 min on separate occasions, at moderate and high intensity. The dependent variable examined …

Hidden In Plain View: Legal Geography From A Visual Perspective, Irus Braverman

Journal Articles

Law, with a capital “L” at least, is not particularly fond of hiding itself. In order to be effective, law must be asserted in the world; it must be acknowledged; and, most importantly, it must be visually seen. Why, then, would law hide itself in space? And, perhaps more importantly, how would it do so? And why would such hidden places of law be of importance to us? This paper explores the dual project of seeing and concealing within the context of legal geography. It examines how law sees the physical landscape and how it is seen from a spatial …

Severity And Characteristics Of Developmental Delay Can Be Assessed Using Variability Measures Of Sitting Posture, Anastasia Kyvelidou, Regina T. Harbourne, Nikolaos Stergiou

Journal Articles

Purpose: We sought to identify measures of variability from sitting postural sway that are significantly different among infants who were developing typically, those who were developmentally delayed or hypotonic, and those who later on had a diagnosis of spastic or athetoid cerebral palsy.

Methods: Sixty-five infants were evaluated when they were just developing the ability to sit upright by assessing center of pressure (COP) data, using measures of both amount and temporal organization of COP variability.

Results: The results indicated that measures of variability of COP could discriminate between infants with developmental delay and infants with cerebral palsy and add …

Reliability Of Center Of Pressure Measures For Assessing The Development Of Sitting Postural Control In Infants With Or At Risk Of Cerebral Palsy, Anastasia Kyvelidou, Regina T. Harbourne, Valerie K. Shostrom, Nikolaos Stergiou

Journal Articles

Objective

To establish the test-retest reliability of linear and nonlinear measures, including intra- and intersession reliability, when used to analyze the center of pressure (COP) time series during the development of infant sitting postural control in infants with or at risk for cerebral palsy (CP).

Design

Longitudinal study.

Setting

University hospital laboratory.

Participants

Infants with or at risk for CP (N=18; mean age ± SD at entry into the study, 13.7±3.6mo).

Interventions

Not applicable.

Main Outcome Measures

Infant sitting COP data were recorded for 3 trials at each session (2 sessions for each month within 1 week) for 4 consecutive …

Rights, Privileges, And Access To Information, Alina Ng

Journal Articles

Protecting property rights in creative works represents a classic institutional approach to the specific economic problems of nonrivalness and non-excludability of information. By providing the copyright owner with an enforceable right against non-paying members of society, copyright laws encourage the production and dissemination of literary and artistic works to society for educational purposes. Implicit in the grant of property rights is the assumption that commercial incentives foster creative activity and productivity. In recent years, literary and artistic works have increasingly become the subject matter of exclusive property rights and control, particularly as emerging technologies provide users of creative works with …

Emotional Faces Capture Spatial Attention In 5-Year-Old Children, Kit K. Elam, Joshua M. Carlson, Lisabeth Dilalla, Karen S. Reinke

Journal Articles

No abstract provided.

The Peoples Path: Conflict And Cooperation In The Acquisition Of The Appalachian Trail, Sarah Mittlefehldt

Journal Articles

No abstract provided.

Governing With Clean Hands: Automated Public Toilets And Sanitary Surveillance, Irus Braverman

Journal Articles

To anyone familiar with the story of urban decay in major American cities in the 1980s – and with the subsequent abolition of toilets from city streets – the introduction of automated public toilets (APTs) to urban spaces sounds like very good news. This article explores the re-democratizing message that commonly accompanies the introduction of APTs to North American city streets as well as their on-the-ground manifestations. It focuses on two major components of APTs: privatization and automation. The process of privatization, which characterizes most APT operations in North America, carries with it various exclusionary effects that stand in stark …

Plasticity Of Lipid-Protein Interactions In The Function And Topogenesis Of The Membrane Protein Lactose Permease From Escherichia Coli, Mikhail Bogdanov, Philip Heacock, Ziqiang Guan, William Dowhan

Journal Articles

Phosphatidylcholine (PC) has been widely used in place of naturally occurring phosphatidylethanolamine (PE) in reconstitution of bacterial membrane proteins. However, PC does not support native structure or function for several reconstituted transport proteins. Lactose permease (LacY) of Escherichia coli, when reconstituted in E. coli phospholipids, exhibits energy-dependent uphill and energy-independent downhill transport function and proper conformation of periplasmic domain P7, which is tightly linked to uphill transport function. LacY expressed in cells lacking PE and containing only anionic phospholipids exhibits only downhill transport and lacks native P7 conformation. Reconstitution of LacY in the presence of E. coli-derived PE, but not …

Response To Chastin Et Al.: Analysis Of Nonlinear Patterns Of Activity, James T. Cavanaugh, Nicholas Stergiou

Journal Articles

We appreciate the thoughtful commentary by Chastin and colleagues regarding our recent article entitled “Nonlinear Analysis of Ambulatory Activity Patterns in Community-dwelling Older Adults.” (1) We fully agree with their observation that the application of nonlinear analytical tools to accelerometry data is an emerging area of research that shows potential for illuminating the complex nature of physical activity profiles. We also welcome the opportunity to discuss their concerns regarding (a) our application of detrended fluctuation analysis (DFA), entropy rate, and approximate entropy to natural activity data and (b) our narrow focus on stepping activity.

Treatment With Pharmacological Agents In Peripheral Arterial Disease Patients Does Not Result In Biomechanical Gait Changes, Jessie M. Huisinga, Iraklis Pipinos, Nikolaos Stergiou, Jason Johanning

Journal Articles

Pharmacological treatment has been used to alleviate the claudication symptoms and improve walking performance in peripheral arterial disease (PAD) patients. However, the effects of claudication treatments on gait mechanics have not been objectively indentified with biomechanical techniques. For this study, 20 PAD patients were assigned to take either pentoxifylline (n = 11) or cilostazol (n = 9), the two FDA-approved pharmacological therapies used to treat intermittent claudication symptoms. All patients completed a gait evaluation protocol that involved the acquisition of kinematic and kinetic gait data before use of the medication and after 12 weeks of treatment. Results showed that treatment …

Head And Shoulder Posture Affect Scapular Mechanics And Muscle Activity In Overhead Tasks, Charles A. Thigpen, Darin A. Padua, Lori A. Michener, Kevin M. Guskiewicz, Carol Guiliani, Jay D. Keener, Nikolaos Stergiou

Journal Articles

Forward head and rounded shoulder posture (FHRSP) is theorized to contribute to alterations in scapular kinematics and muscle activity leading to the development of shoulder pain. However, reported differences in scapular kinematics and muscle activity in those with forward head and rounded shoulder posture are confounded by the presence of shoulder pain. Therefore, the purpose of this study was to compare scapular kinematics and muscle activity in individuals free from shoulder pain, with and without FHRSP. Eighty volunteers were classified as having FHRSP or ideal posture. Scapular kinematics were collected concurrently with muscle activity from the upper and lower trapezius …

Abnormal Joint Powers Before And After The Onset Of Claudication Symptoms, Panagiotis Koutakis, Jason Johanning, Sara A. Myers, Nikolaos Stergiou, G. Matthew Longo, Iraklis Pipinos

Journal Articles

Objective: Claudication is the most common manifestation of peripheral arterial disease, producing significant ambulatory compromise. Our study evaluated patients with bilateral lower limb claudication and characterized their gait abnormality based on advanced biomechanical analysis using joint torques and powers.

Methods: Twenty patients with bilateral claudication (10 with isolated aortoiliac disease and 10 with combined aortoiliac and femoropopliteal disease) and 16 matched controls ambulated on a walkway while 3-dimensional biomechanical data were collected. Patients walked before and after onset of claudication pain. Joint torques and powers at early, mid, and late stance for the hip, knee, and ankle joints were calculated …

The Effect Of Virtual Reality On Gait Variability, Dimitrios Kastavelis, Mukul Mukherjee, Leslie M. Decker, Nikolaos Stergiou

Journal Articles

Optic Flow (OF) plays an important role in human locomotion and manipulation of OF characteristics can cause changes in locomotion patterns. The purpose of the study was to investigate the effect of the velocity of optic flow on the amount and structure of gait variability. Each subject underwent four conditions of treadmill walking at their self-selected pace. In three conditions the subjects walked in an endless virtual corridor, while a fourth control condition was also included. The three virtual conditions differed in the speed of the optic flow displayed as follows – same speed (OFn), faster (OFf), and slower (OFs) …

Influence Of Blood Contamination On Bond Strength Of A Self-Etching System, Ellen Cristina De Carvalho Mendonça, Samuel Nilo Vieira, Fernando Aparecido Kawaguchi, John Powers, Adriana Bona Matos

Journal Articles

OBJECTIVES: To detect the influence of blood contamination (BC) on the bond strength (BS) of a self-etching bonding system (SES) to enamel and dentine.

METHODS: 25 human molars were longitudinally sectioned on the mesio-distal axis in order to obtain 50 specimens, which were embedded in acrylic resin. At first, the specimens were ground to expose a flat surface of enamel, and a bond strength test was performed. Afterwards, the samples were ground again in order to obtain a flat surface of dentine. Ten groups (total: n=100) were assigned according to substrate (enamel and dentine), step in the bonding sequence when …

Histamine Reduces Flash Sensitivity Of On Ganglion Cells In The Primate Retina, Nikolay P Akimov, David W Marshak, Laura J Frishman, Randolph D Glickman, Rafail G Yusupov

Journal Articles

PURPOSE. In Old World primates, the retina receives input from histaminergic neurons in the posterior hypothalamus. They are a subset of the neurons that project throughout the central nervous system and fire maximally during the day. The contribution of these neurons to vision, was examined by applying histamine to a dark-adapted, superfused baboon eye cup preparation while making extracellular recordings from peripheral retinal ganglion cells. METHODS. The stimuli were 5-ms, 560-nm, weak, full-field flashes in the low scotopic range. Ganglion cells with sustained and transient ON responses and two cell types with OFF responses were distinguished; their responses were recorded …

Evolutionary Conservation Of Residues In Vertebrate Dna Polymerase N Conferring Low Fidelity And Bypass Activity., Kei-Ichi Takata, Mercedes E Arana, Mineaki Seki, Thomas A Kunkel, Richard D Wood

Journal Articles

POLN is a nuclear A-family DNA polymerase encoded in vertebrate genomes. POLN has unusual fidelity and DNA lesion bypass properties, including strong strand displacement activity, low fidelity favoring incorporation of T for template G and accurate translesion synthesis past a 5S-thymine glycol (5S-Tg). We searched for conserved features of the polymerase domain that distinguish it from prokaryotic pol I-type DNA polymerases. A Lys residue (679 in human POLN) of particular interest was identified in the conserved 'O-helix' of motif 4 in the fingers sub-domain. The corresponding residue is one of the most important for controlling fidelity of prokaryotic pol I …

The Effect Of Pharmacological Treatment On Gait Biomechanics In Peripheral Arterial Disease Patients, Jessie M. Huisinga, Iraklis Pipinos, Jason Johanning, Nikolaos Stergiou

Journal Articles

Background: Pharmacological treatment has been advocated as a first line therapy for Peripheral Arterial Disease (PAD) patients suffering from intermittent claudication. Previous studies document the ability of pharmacological treatment to increase walking distances. However, the effect of pharmacological treatment on gait biomechanics in PAD patients has not been objectively evaluated as is common with other gait abnormalities. Methods: Sixteen patients were prescribed an FDA approved drug (Pentoxifylline or Cilostazol) for the treatment of symptomatic PAD. Patients underwent baseline gait testing prior to medication use which consisted of acquisition of ground reaction forces and kinematics while walking in a pain free …

Blind Rage? Heightened Anger Is Associated With Altered Amygdala Responses To Masked And Unmasked Fearful Faces, Joshua M. Carlson, Tsafrir Greenberg, Lilianne R. Mujica-Parodi

Journal Articles

No abstract provided.

Cellular Dynamic Simulator: An Event Driven Molecular Simulation Environment For Cellular Physiology, Michael J Byrne, M Neal Waxham, Yoshihisa Kubota

Journal Articles

In this paper, we present the Cellular Dynamic Simulator (CDS) for simulating diffusion and chemical reactions within crowded molecular environments. CDS is based on a novel event driven algorithm specifically designed for precise calculation of the timing of collisions, reactions and other events for each individual molecule in the environment. Generic mesh based compartments allow the creation / importation of very simple or detailed cellular structures that exist in a 3D environment. Multiple levels of compartments and static obstacles can be used to create a dense environment to mimic cellular boundaries and the intracellular space. The CDS algorithm takes into …

Progressive Regression Of Left Ventricular Hypertrophy Two Years After Bariatric Surgery, Mohamed F Algahim, Thomas R Lux, Joshua G Leichman, Anthony F Boyer, Charles C Miller, Susan T Laing, Erik B Wilson, Terry Scarborough, Sherman Yu, Brad Snyder, Carol Wolin-Riklin, Ursula G Kyle, Heinrich Taegtmeyer

Journal Articles

BACKGROUND: Obesity is a systemic disorder associated with an increase in left ventricular mass and premature death and disability from cardiovascular disease. Although bariatric surgery reverses many of the hormonal and hemodynamic derangements, the long-term collective effects on body composition and left ventricular mass have not been considered before. We hypothesized that the decrease in fat mass and lean mass after weight loss surgery is associated with a decrease in left ventricular mass.

METHODS: Fifteen severely obese women (mean body mass index [BMI]: 46.7+/-1.7 kg/m(2)) with medically controlled hypertension underwent bariatric surgery. Left ventricular mass and plasma markers of systemic …

A Direct Role For Secretory Phospholipase A2 And Lysophosphatidylcholine In The Mediation Of Lps-Induced Gastric Injury, Elizabeth J Dial, Duy M Tran, Jimmy J Romero, Mayssa Zayat, Lenard M Lichtenberger

Journal Articles

Endotoxemia from sepsis can injure the gastrointestinal tract through mechanisms that have not been fully elucidated. We have shown that LPS induces an increase in gastric permeability in parallel with the luminal appearance of secretory phospholipase A2 (sPLA2) and its product, lysophosphatidylcholine (lyso-PC). We proposed that sPLA2 acted on the gastric hydrophobic barrier, composed primarily of phosphatidylcholine (PC), to degrade it and produce lyso-PC, an agent that is damaging to the mucosa. In the present study, we have tested whether lyso-PC and/or sPLA2 have direct damaging effects on the hydrophobic barriers of synthetic and mucosal surfaces. Rats were administered LPS …

Thoracic Aortic Disease In Tuberous Sclerosis Complex: Molecular Pathogenesis And Potential Therapies In Tsc2+/- Mice, Jiumei Cao, Limin Gong, Dong-Chuan Guo, Ulrike Mietzsch, Shao-Qing Kuang, Callie S Kwartler, Hazim Safi, Anthony Estrera, Michael J Gambello, Dianna M Milewicz

Journal Articles

Tuberous sclerosis complex (TSC) is a genetic disorder with pleiotropic manifestations caused by heterozygous mutations in either TSC1 or TSC2. One of the less investigated complications of TSC is the formation of aneurysms of the descending aorta, which are characterized on pathologic examination by smooth muscle cell (SMC) proliferation in the aortic media. SMCs were explanted from Tsc2(+/-) mice to investigate the pathogenesis of aortic aneurysms caused by TSC2 mutations. Tsc2(+/-) SMCs demonstrated increased phosphorylation of mammalian target of rapamycin (mTOR), S6 and p70S6K and increased proliferation rates compared with wild-type (WT) SMCs. Tsc2(+/-) SMCs also had reduced expression of …

Determining The Age Of Individual Lepeophtheirus Salmonis(Krøyer, 1837) Copepodids By Measuring Stored Lipid Volume;Proof Of Principle, Ian Bricknell, S. J. Mcbeath, P. F. Cook, J. E. Bron

Journal Articles

No abstract provided.