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All ETDs from UAB

Theses/Dissertations

2007

Master of Science (MS) School of Health Professions

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The Association Between Insulin And Inflammation In African American And European American Children, Jessica A. Alvarez Jan 2007

The Association Between Insulin And Inflammation In African American And European American Children, Jessica A. Alvarez

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Insulin has anti-inflammatory properties. Markers of inflammation (MOI) increase in the postprandial state. African Americans (AA) have higher post-challenge insulin concentrations compared to European Americans (EA). The objective of this study was to investigate the relationship between insulin and MOI in both the fasting and postprandial state. We hypothesized that, after accounting for confounding factors, fasting and postprandial insulin would be inversely associated with MOI, and that AA would have a lower postprandial inflammatory response because of a higher insulin response. C-reactive protein (CRP), interleukin-6 (IL6), soluble tumor necrosis factor receptor type 2 (sTNF-R2), and insulin concentrations were assessed at …


Development And Testing Of Feed - A Feedback Expert System For Ems Documentation, Devashish Saini Jan 2007

Development And Testing Of Feed - A Feedback Expert System For Ems Documentation, Devashish Saini

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Emergency Medical Services (EMS) are delivered in a chaotic, dynamic, unpre-dictable, and therefore error-prone environment. Deviations from protocol are common and some may be severe enough to cause harm to the patient. EMS personnel, like all healthcare providers, can benefit from feedback, continued education and medical over-sight. A Feedback Expert system for EMS Documentation (FEED) was developed for providing feedback to EMS personnel after the ambulance run is completed and docu-mented electronically. FEED’s knowledge base was derived from Alabama State EMS Protocols and discussions with two EMS faculty members from UAB School of Medi-cine. FEED is rule-based and uses confidence …


The Influence Of Insulin On Lipolysis In African American And Caucasian Prepubertal, Premenopausal, And Postmenopausal Females, Laura Lee T Goree Jan 2007

The Influence Of Insulin On Lipolysis In African American And Caucasian Prepubertal, Premenopausal, And Postmenopausal Females, Laura Lee T Goree

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African Americans, compared to Caucasians, may have chronically suppressed free fatty acid (FFA) mobilization due to basal and postprandial hyperinsulinemia. The pur-pose of this study was to determine if lower FFA among African Americans are due to higher insulin concentration and if this ethnic difference in FFA, beta cell function, and insulin suppression of FFA declines with age. Subjects who qualified underwent a fre-quently-sampled intravenous glucose tolerance test (FSIGT) for determination of insulin sensitivity (Si) and the acute insulin response to glucose (AIRg). Body composition and fat distribution were assessed with dual-energy x-ray absorptiometry (DXA) and com-puted tomography (CT), respectively. …


Using Genetic Admixture And Lipo Protein Lipase Polymorphisms To Explain Variations In Plasma Triglycerides And High Density Lipoprotein Cholesterol In Premenopauasal African And European American Females, Nihal Omar Natour Jan 2007

Using Genetic Admixture And Lipo Protein Lipase Polymorphisms To Explain Variations In Plasma Triglycerides And High Density Lipoprotein Cholesterol In Premenopauasal African And European American Females, Nihal Omar Natour

All ETDs from UAB

Although African Americans (AA) are well known to be more obese and more in-sulin resistant than European Americas (EA), several studies have shown that AA have lower plasma triglyceride (TG) and higher high density lipoprotein cholesterol (HDL-C). The reasons for these levels of TG and HDL-C are not understood, and scientists have suggested a role of lipoprotein lipase (LPL), a key regulator of TG rich lipoproteins me-tabolism that is also thought to indirectly affect HDL-C metabolism. To investigate the extent to which these observed differences in TG and HDL-C are due to genetic makeup, we investigated the role of genetic …