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Freesurfer-Initiated Fully-Automated Subcortical Brain Segmentation In Mri Using Large Deformation Diffeomorphic Metric Mapping., Ali R Khan, Lei Wang, Mirza Faisal Beg
Freesurfer-Initiated Fully-Automated Subcortical Brain Segmentation In Mri Using Large Deformation Diffeomorphic Metric Mapping., Ali R Khan, Lei Wang, Mirza Faisal Beg
Brain and Mind Institute Researchers' Publications
Fully-automated brain segmentation methods have not been widely adopted for clinical use because of issues related to reliability, accuracy, and limitations of delineation protocol. By combining the probabilistic-based FreeSurfer (FS) method with the Large Deformation Diffeomorphic Metric Mapping (LDDMM)-based label-propagation method, we are able to increase reliability and accuracy, and allow for flexibility in template choice. Our method uses the automated FreeSurfer subcortical labeling to provide a coarse-to-fine introduction of information in the LDDMM template-based segmentation resulting in a fully-automated subcortical brain segmentation method (FS+LDDMM). One major advantage of the FS+LDDMM-based approach is that the automatically generated segmentations generated are …
Neuroimaging Studies Of Psychological Interventions For Mood And Anxiety Disorders: Empirical And Methodological Review., Paul A Frewen, David J A Dozois, Ruth A Lanius
Neuroimaging Studies Of Psychological Interventions For Mood And Anxiety Disorders: Empirical And Methodological Review., Paul A Frewen, David J A Dozois, Ruth A Lanius
Psychology Publications
This article reviews the methods and results of published neuroimaging studies of the effects of structured psychological interventions for mood and anxiety disorders. The results are consistent with neural models of improved affective- and self-regulation, as evidenced by psychotherapeutic modulation of brain metabolic activity within the dorsolateral, ventrolateral, and medial prefrontal cortices, the anterior cingulate, the posterior cingulate/precuneus, and the insular cortices. Specific recommendations for future studies are outlined, and the clinical and theoretical significance of this research is discussed.
Clinical And Neural Correlates Of Alexithymia In Posttraumatic Stress Disorder., Paul A Frewen, Ruth A Lanius, David J A Dozois, Richard W J Neufeld, Clare Pain, James W Hopper, Maria Densmore, Todd K Stevens
Clinical And Neural Correlates Of Alexithymia In Posttraumatic Stress Disorder., Paul A Frewen, Ruth A Lanius, David J A Dozois, Richard W J Neufeld, Clare Pain, James W Hopper, Maria Densmore, Todd K Stevens
Psychology Publications
Individuals with posttraumatic stress disorder (PTSD) often exhibit deficits in emotional experience and expression, which suggests that certain individuals with PTSD may be alexithymic. In this study, in a sample of 105 individuals with PTSD, clinical correlates of alexithymia included reexperiencing, hyperarousal, numbing, dissociative symptoms, and retrospectively reported experiences of childhood emotional neglect. In a subsample of 26 individuals with PTSD related to a motor vehicle accident, functional neural responses to trauma-script imagery were associated with severity of alexithymia, including increased right posterior-insula and ventral posterior-cingulate activation and decreased bilateral ventral anterior-cingulate, ventromedial prefrontal, anterior-insula, and right inferior frontal cortex …
Neuronal Nicotinic Acetylcholine Receptors And Alcohol Preference In Mice: Analyses Of Brain Gene Expression And Co-Segregation Studies, Melissa Nicole Symons
Neuronal Nicotinic Acetylcholine Receptors And Alcohol Preference In Mice: Analyses Of Brain Gene Expression And Co-Segregation Studies, Melissa Nicole Symons
Digitized Theses
Attempts to discover the genetic determinants of alcohol and nicotine addiction have been underway for many years. A common site of action for both nicotine and alcohol effects are neuronal nicotinic acetylcholine receptors (nAChR). This thesis deals with the molecular analysis of four nAChR subunits {Chrna4, Chrnb2, Chma5, and Chrna7) and their relationship with alcohol preference (AP) in mice. The alcohol- preferring C57BL∕6J (B6) and alcohol-avoiding DBA∕2J (D2) strains of mice provide a well established genetic model for the study of AP. Semi-quantitative RT-PCR was used to assess πAChR gene expression in the brains of B6 and D2 mice with …