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Developmental Trajectories Of Executive And Verbal Processes In Children With Phenylketonuria, Zoe Hawks
Developmental Trajectories Of Executive And Verbal Processes In Children With Phenylketonuria, Zoe Hawks
Arts & Sciences Electronic Theses and Dissertations
Phenylketonuria (PKU) is a recessive disorder characterized by disruption in the metabolism of the amino acid phenylalanine. Using a verbal fluency task, previous studies demonstrated that word production is reduced in individuals with PKU relative to controls. Beyond word production, verbal fluency output can be scored for clustering and switching, which enable characterization of verbal and executive processes, respectively. The present study is the first to evaluate clustering and switching in PKU within a longitudinal design, thereby elucidating the developmental time course of core cognitive processes. To this end, semantic (animals, food/drink) and phonemic (S words, F words) fluency data …
Modeling Complex Patterns Of Differential Dna Methylation That Associate With Expression Change, Christopher E. Schlosberg
Modeling Complex Patterns Of Differential Dna Methylation That Associate With Expression Change, Christopher E. Schlosberg
Arts & Sciences Electronic Theses and Dissertations
Gene expression is driven by specific combinations of transcription factors binding to regulatory sequences to define cell type expression profiles. Changes in DNA sequence alter transcription factor binding affinities and gene expression, and DNA methylation is an additional source of variation that is maintained throughout cellular division. Numerous genomic studies are underway to determine which genes are abnormally regulated by DNA methylation in disease. However, we have a poor understanding of how disease-specific methylation variation affects expression. Global DNA demethylation agents have been clinically approved for use in cancer, which has spurred interest in identifying genes which would be most …
Start Lifelong Asset Building With Universal And Progressive Child Development Accounts, Jin Huang, Margaret S. Sherraden, Margaret M. Clancy, Michael Sherraden, Trina R. Shanks
Start Lifelong Asset Building With Universal And Progressive Child Development Accounts, Jin Huang, Margaret S. Sherraden, Margaret M. Clancy, Michael Sherraden, Trina R. Shanks
Center for Social Development Research
This policy action statement was developed by members of the networks engaged in the Grand Challenges to Build Financial Capability and Assets for All and to Reduce Extreme Economic Inequality. The Grand Challenges initiative’s policy action statements present proposals emerging from Social Innovation for America’s Renewal, a policy conference organized by the Center for Social Development at Washington University in collaboration with theAmerican Academy of Social Work & Social Welfare, which is leading the Grand Challenges for Social Work initiative to champion social progress through a national agenda powered by science.