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H-Ns, Its Family Members And Their Regulation Of Virulence Genes In Shigella Species, Michael A. Picker, Helen J. Wing
H-Ns, Its Family Members And Their Regulation Of Virulence Genes In Shigella Species, Michael A. Picker, Helen J. Wing
Life Sciences Faculty Research
The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls virulence by silencing many genes found on the large virulence plasmid. H-NS and its paralogue StpA are present in all four Shigella spp., but a second H-NS paralogue, Sfh, is found in the Shigella flexneri type strain 2457T, which is routinely used in studies of Shigella pathogenesis. While StpA and Sfh have been proposed to serve as “molecular backups” for H-NS, the apparent redundancy of these proteins is questioned by in vitro …