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Articles 1 - 5 of 5
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The Role Of Valproic Acid, A Histone Deacetylase Inhibitor, In Reducing Anxiety Levels In Rats: An Epigenetics Study, Juliet Buteme
The Role Of Valproic Acid, A Histone Deacetylase Inhibitor, In Reducing Anxiety Levels In Rats: An Epigenetics Study, Juliet Buteme
Honors College Theses
Rats, like humans, show personality traits: they are born with different anxiety levels (i.e., high (HAn) or low anxiety (LAn) levels). In this study, we investigated (1) if treatment with valproic acid (VPA) can lower anxiety level in trait anxiety rats and (2) how VPA may interact with environment (e.g., enriched (EE), standard (SE) and isolated environments (IE)). VPA is a deacetylase inhibitor that increases Histone 3 acetylation, a known epigenetic mechanism that interacts with stress response proteins, and treats epilepsy and mood disorders. Since rats reared in IE exhibit heightened anxiety levels as compared to those in EE, we …
Role Of The Orphan Crispr 2 In Enterococcus Faecalis, Andriy Barchuk
Role Of The Orphan Crispr 2 In Enterococcus Faecalis, Andriy Barchuk
Honors College Theses
Enterococcus faecalis is a Gram-positive aerotolerant anaerobic bacterium primarily found as a member of the human and animal intestinal flora. Enterococcus faecalis along with 27 other species comprise the genus Enterococcus. Out of the whole genus E. faecalis and E. faecium are the second most common nosocomial cause for urinary tract and wound infections. The treatment of the infections is made even more complex due to E. faecalis resistance to last-resort drugs like vancomycin. An inverse relationship has been observed in the species between antibiotic resistance and presence of the CRISPR-cas locus. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats and …
Recyclable Organocatalysis Of One-Pot Michael/Mannich/Lactamization Sequence For Asymmetric Synthesis Of Fluorinated Poly-Substituted 2-Piperidinones, Anthony P. Tran
Recyclable Organocatalysis Of One-Pot Michael/Mannich/Lactamization Sequence For Asymmetric Synthesis Of Fluorinated Poly-Substituted 2-Piperidinones, Anthony P. Tran
Honors College Theses
2-piperidinone (δ-lactam), a bio-interesting nitrogen-containing six-membered ring compound, has attracted much interest from researchers both in synthetic and medicinal chemistry. Polysubstituted piperidine derivatives, such as the δ-lactam, serve as a synthon for numerous biologically relevant structures and pharmaceutical agents. A novel one-pot asymmetric Michael/Mannich/Lactamization sequence promoted by recyclable fluorous bifunctional cinchona alkaloid–thiourea organocatalysts is introduced for the synthesis of polysubstituted 2-piperidinones bearing four contiguous stereocenters, one of which is a fluorinated quaternary chiral center with excellent stereoselectivities (ee up to >99%, dr up to >20:1).
Towards A Healthy Neighborhood: Recommendations For Health Assessments Of Future Development In Upham’S Corner, Luc Figueiredo Miller
Towards A Healthy Neighborhood: Recommendations For Health Assessments Of Future Development In Upham’S Corner, Luc Figueiredo Miller
Honors College Theses
Historic growth in Boston, Massachusetts, belies dramatic gaps in socio-economic status among residents and corresponding increases in health disparities between low income and more affluent Boston neighborhoods. The Fairmount/Indigo Planning Initiative Corridor Plan is a renewed investment in Boston’s poorest communities that may potentially tackle these inequities. The plan aims to link neighborhoods that are cut off from downtown to the heart of the city. Such investment in rapid transit may combat the spatial isolation found to negatively affect health outcomes but similar transportation upgrades in other American cities have been associated with gentrification and displacement (Pollack et al, 2010). …
Sternal Precautions: Is It Necessary To Restrict Our Patients?, Lauren Belyea
Sternal Precautions: Is It Necessary To Restrict Our Patients?, Lauren Belyea
Honors College Theses
This paper is based on the inquiry about the effects of sternal precautions as part of a patient’s recovery following a sternotomy. It is important to explore this because nurses should always be asking themselves “why am I doing what I am doing with my patients?” “Which of my practices are evidence based and which do not have any evidence to support them?” (MeInyk, 2009). If sternal precautions are indeed overly restrictive and preventing patients from achieving the best possible recovery outcomes, it is the job of the nurse and other healthcare providers to make changes to the current practice.