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Narrowband Ultraviolet B Response In Cutaneous T-Cell Lymphoma Is Characterized By Increased Bacterial Diversity And Reduced Staphylococcus Aureus And Staphylococcus Lugdunensis, Madeline J. Hooper, Gail L. Enriquez, Francesca L. Veon, Tessa M. Lewitt, Dagmar Sweeney, Stefan J. Green, Patrick C. Seed, Jaehyuk Choi, Joan Guitart, Michael B. Burns, Xiaolong A. Zhou
Narrowband Ultraviolet B Response In Cutaneous T-Cell Lymphoma Is Characterized By Increased Bacterial Diversity And Reduced Staphylococcus Aureus And Staphylococcus Lugdunensis, Madeline J. Hooper, Gail L. Enriquez, Francesca L. Veon, Tessa M. Lewitt, Dagmar Sweeney, Stefan J. Green, Patrick C. Seed, Jaehyuk Choi, Joan Guitart, Michael B. Burns, Xiaolong A. Zhou
Biology: Faculty Publications and Other Works
Skin microbiota have been linked to disease activity in cutaneous T-cell lymphoma (CTCL). As the skin microbiome has been shown to change after exposure to narrowband ultraviolet B (nbUVB) phototherapy, a common treatment modality used for CTCL, we performed a longitudinal analysis of the skin microbiome in CTCL patients treated with nbUVB. 16S V4 rRNA gene amplicon sequencing for genus-level taxonomic resolution, tuf2 amplicon next generation sequencing for staphylococcal speciation, and bioinformatics were performed on DNA extracted from skin swabs taken from lesional and non-lesional skin of 25 CTCL patients receiving nbUVB and 15 CTCL patients not receiving nbUVB from …
Distinct Roles For Free Fatty Acid Receptor 3 (Ffar3) In Vagal And Spinal Afferents Regulating Energy Balance And Glucose Homeostasis, Tyler M. Cook
Distinct Roles For Free Fatty Acid Receptor 3 (Ffar3) In Vagal And Spinal Afferents Regulating Energy Balance And Glucose Homeostasis, Tyler M. Cook
Dissertations
energy balance, glucose homeostasis, gut-brain axis, microbiome, nutrient sensing, satiety
Interplay Between Human Microbiota And Celiac Disease, John James Colgan
Interplay Between Human Microbiota And Celiac Disease, John James Colgan
Master's Theses
Celiac disease is an autoimmune disorder of the small intestine in which gluten, an energy-storage protein in wheat and other cereals, elicits an immune response leading to villous atrophy. Despite a strong genetic component, the disease arises sporadically over the lifetime leading us to hypothesize the microbiome might be a trigger. Here, we re-examined 16S data from 3 prior studies examining celiac disease and the microbiome with newer computational tools: the dada2 and PICRUSt 2 pipelines. Our results both confirmed findings of previous studies and generated new data regarding the celiac microbiome of India and Mexico. The datasets were also …
Integrating Current Analyses Of The Breast Cancer Microbiome, Sidra Sohail
Integrating Current Analyses Of The Breast Cancer Microbiome, Sidra Sohail
Master's Theses
Breast cancer is the leading cause of cancer death for women in the US. Many cancertypes have significant associations with their resident microbial communities - emerging evidence suggests that breast cancers also interact with the local tissue-associated microbiota. Studies have examined the relationship between breast cancer and its microbiome, however, the studies varied in their approaches used to evaluate these relationships. Microbiome research advances rapidly and analysis pipelines and databases are updated frequently. This dynamic environment makes inter-study comparisons and superficial evaluations challenging as no two studies are using the same standards for evaluation. Researchers have observed the microbiota of …
Identification Of Shared And Disease-Specific Host Gene–Microbiome Associations Across Human Diseases Using Multi-Omic Integration, Sambhawa Priya, Michael B. Burns, Tonya Ward, Ruben A.T. Mars, Beth Adamowicz, Eric F. Lock, Purna C. Kashyap, Dan Knights, Ran Blekhman
Identification Of Shared And Disease-Specific Host Gene–Microbiome Associations Across Human Diseases Using Multi-Omic Integration, Sambhawa Priya, Michael B. Burns, Tonya Ward, Ruben A.T. Mars, Beth Adamowicz, Eric F. Lock, Purna C. Kashyap, Dan Knights, Ran Blekhman
Biology: Faculty Publications and Other Works
While gut microbiome and host gene regulation independently contribute to gastrointestinal disorders, it is unclear how the two may interact to influence host pathophysiology. Here we developed a machine learning-based framework to jointly analyse paired host transcriptomic (n = 208) and gut microbiome (n = 208) profiles from colonic mucosal samples of patients with colorectal cancer, inflammatory bowel disease and irritable bowel syndrome. We identified associations between gut microbes and host genes that depict shared as well as disease-specific patterns. We found that a common set of host genes and pathways implicated in gastrointestinal inflammation, gut barrier protection and energy …
Investigating The Bactericidal Activity Of Lactobacillus Crispatus Cell-Free-Supernatant, Omar Majed Abdul-Rahim
Investigating The Bactericidal Activity Of Lactobacillus Crispatus Cell-Free-Supernatant, Omar Majed Abdul-Rahim
Dissertations
Antimicrobial-resistant (AMR) microorganisms are an increasingly seriousproblem worldwide, accounting for thousands of fatalities annually. The current literature on combating AMR pathogens often centers on commensal microbes such as Lactobacillus species, which are most frequently found in asymptomatic ‘healthy’ patients and are believed to elicit protective effects. In this dissertation, I sought to investigate the protective effect of Lactobacillus crispatus, utilizing our vast collection of clinical isolates. Previous work from our lab had found that cell-free-supernatant (CFS) of L. crispatus is robustly bactericidal, and that this killing activity does not depend on hydrogen peroxide or lactic acid. We identified phenyl-lactic acid …