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Fgf4-Dependent Stem Cells Derived From Rat Blastocysts Differentiate Along The Trophoblast Lineage, Kazuo Asanoma, M. A.Karim Rumi, Lindsey N. Kent, Damayanti Chakraborty, Stephen J. Renaud, Norio Wake, Dong Soo Lee, Kaiyu Kubota, Michael J. Soares Mar 2011

Fgf4-Dependent Stem Cells Derived From Rat Blastocysts Differentiate Along The Trophoblast Lineage, Kazuo Asanoma, M. A.Karim Rumi, Lindsey N. Kent, Damayanti Chakraborty, Stephen J. Renaud, Norio Wake, Dong Soo Lee, Kaiyu Kubota, Michael J. Soares

Paediatrics Publications

Differentiated trophoblast cell lineages arise from trophoblast stem (TS) cells. To date such a stem cell population has only been established in the mouse. The objective of this investigation was to establish TS cell populations from rat blastocysts. Blastocysts were cultured individually on a feeder layer of rat embryonic fibroblasts (REFs) in fibroblast growth factor-4 (FGF4) and heparin supplemented culture medium. Once cell colonies were established REF feeder layers could be replaced with REF conditioned medium. The blastocyst-derived cell lines, in either proliferative or differentiated states, did not express genes indicative of ICM-derived tissues. In the proliferative state the cells …


Ifpa Meeting 2010 Workshops Report Ii: Placental Pathology; Trophoblast Invasion; Fetal Sex; Parasites And The Placenta; Decidua And Embryonic Or Fetal Loss; Trophoblast Differentiation And Syncytialisation, A. Al-Khan, I. L. Aye, I. Barsoum, A. Borbely, E. Cebral, G. Cerchi, V. L. Clifton, S. Collins, T. Ross, Bruce C. Carleton, Michael R. Hayden, Martin Hosking, Sean Virani, Stuart Macleod, Rod Rassekh, Anne Smith, Liam Brunham, Neil H. Shear, Gideon Koren, Geoffrey Liu, Michael J. Rieder, Richard Kim, Maurica Maher, David Flockhart, Lawrence Lesko, Jenna Rhoades Mar 2011

Ifpa Meeting 2010 Workshops Report Ii: Placental Pathology; Trophoblast Invasion; Fetal Sex; Parasites And The Placenta; Decidua And Embryonic Or Fetal Loss; Trophoblast Differentiation And Syncytialisation, A. Al-Khan, I. L. Aye, I. Barsoum, A. Borbely, E. Cebral, G. Cerchi, V. L. Clifton, S. Collins, T. Ross, Bruce C. Carleton, Michael R. Hayden, Martin Hosking, Sean Virani, Stuart Macleod, Rod Rassekh, Anne Smith, Liam Brunham, Neil H. Shear, Gideon Koren, Geoffrey Liu, Michael J. Rieder, Richard Kim, Maurica Maher, David Flockhart, Lawrence Lesko, Jenna Rhoades

Paediatrics Publications

Workshops are an important part of the IFPA annual meeting. At IFPA Meeting 2010 diverse topics were discussed in twelve themed workshops, six of which are summarized in this report. 1. The placental pathology workshop focused on clinical correlates of placenta accreta/percreta. 2. Mechanisms of regulation of trophoblast invasion and spiral artery remodeling were discussed in the trophoblast invasion workshop. 3. The fetal sex and intrauterine stress workshop explored recent work on placental sex differences and discussed them in the context of whether boys live dangerously in the womb.4. The workshop on parasites addressed inflammatory responses as a sign of …


Peripheral Pariah Or Regional Rebel? The Allied Democratic Forces And The Uganda/Congo Borderland, Lindsay Scorgie Jan 2011

Peripheral Pariah Or Regional Rebel? The Allied Democratic Forces And The Uganda/Congo Borderland, Lindsay Scorgie

Faculty Publications

The Allied Democratic Forces (ADF) have inflicted damage and insecurity on the Rwenzori region of Uganda for over a decade and, although their strength has diminished, still constitute a threat. This article argues that it is inadequate to see the ADF primarily as an internal Ugandan rebel group. Rather, the group's cross-border dimension with the Democratic Republic of the Congo should be conceptualised as a transnational phenomenon. A borderland analytic framework offers the best means of understanding the movement.