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From Molecules To Medicine: A Future Cure For Preeclampsia?, Mark Santillan, Donna Santillan, Curt Sigmund, Stephen Hunter
From Molecules To Medicine: A Future Cure For Preeclampsia?, Mark Santillan, Donna Santillan, Curt Sigmund, Stephen Hunter
Mark K. Santillan
In the United States, preeclampsia (PreE) affects 5-7% of all pregnancies, yet represents 15% of all maternal-fetal morbidity and mortality. PreE causes fetal growth restriction, oligohydramnios, fetal death, and maternal seizures, stroke, cerebrovascular hemorrhage and death. It has immediate and potentially long-term effects on both the fetus and mother. To date, the molecular pathogenesis of PreE is largely unknown. Multiple pathways, including dysfunctional angiogenesis, inappropriate placentation, oxidative stress and an altered immunological milieu have been proposed as key players in the development of PreE. In addition, genetic factors in all of these pathways are essential components in the etiology of …
Non-Invasive Fetal Genome Sequencing: Opportunities And Challenges., Holly Tabor, Jeffrey Murray, Hilary Gammill, Jacob Kitzman, Matthew Snyder, Mario Ventura, Alexandra Lewis, Ruolan Qiu, Lavone Simmons, Craig Rubens, Mark Santillan, Evan Eichler, Edith Cheng, Michael Bamshad, Jay Shendure
Non-Invasive Fetal Genome Sequencing: Opportunities And Challenges., Holly Tabor, Jeffrey Murray, Hilary Gammill, Jacob Kitzman, Matthew Snyder, Mario Ventura, Alexandra Lewis, Ruolan Qiu, Lavone Simmons, Craig Rubens, Mark Santillan, Evan Eichler, Edith Cheng, Michael Bamshad, Jay Shendure
Mark K. Santillan
No abstract provided.