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The C. Elegans Heterochronic Gene Lin-4 Encodes Small Rnas With Antisense Complementarity To Lin-14, Rosalind Lee, Rhonda Feinbaum, Victor Ambros

Victor R. Ambros

lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, creating a temporal decrease in LIN-14 protein starting in the first larval stage (L1). We have cloned the C. elegans lin-4 locus by chromosomal walking and transformation rescue. We used the C. elegans clone to isolate the gene from three other Caenorhabditis species; all four Caenorhabditis clones functionally rescue the lin-4 null allele of C. elegans. Comparison of the lin-4 genomic sequence from these four species and site-directed mutagenesis of potential open reading frames …

Thermodynamics Of Single-Stranded Rna And Dna Interactions With Oligolysines Containing Tryptophan. Effects Of Base Composition., David Mascotti, Timothy Lohman

David P. Mascotti

No abstract provided.

Domestic Monopoly, Quotas & Contestable Rents, William Rieber

William Rieber

Hexameric Lithium Phenolate: Crystal Structures And Lithium-7 Quadrupole Coupling In Solid And Solution Phases., Lloyd Jackman, Deniz Cizmeciyan, Paul Willard, Michael Nichols

Michael A Nichols

No abstract provided.

Genetic Analyses Of Photopigment Biosynthesis In Eubacteria: A Guiding Light For Algae And Plants, David Bollivar, Carl E. Bauer, Jon Y. Suzuki

David Bollivar

A wide variety of macrocyclic tetrapyrrole compounds are synthesized by cells for use in diverse cellular processes. As shown in Fig. 1, this pathway includes the synthesis of closed tetrapyrrole compounds that contain metals, such as cobalt-containing cobalamin (vitamin B12), nickel-containing methanogenesis coenzyme F430, copper-containing pigment turacin, iron-containing heme and siroheme, and magnesium-containing chlorophylls and bacteriochlorophylls. Also synthesized by this pathway are a variety of open macrocyclic compounds such as the family of bilins that are used as a source of light-harvesting pigments in cyanobacteria, red algae, and cryptophytes as well as the chromophore that is covalently attached to phytochrome …

A Bacterial Protease Perturbs The Paracellular Barrier Function Of Transporting Epithelial Monolayers In Culture, Ali Azghani

Ali Azghani

Avian Hatching Asynchrony: Brood Classification Based On Discriminant Function Analysis Of Nestling Masses, Given Harper, Steven A. Juliano, Charles F. Thompson

Given Harper

Case Notes And Carting Of Bioethical Case Consultations, Benjamin Freedman, Charles Weijer, Eugene Bereza

Charles Weijer

In summary, the usual elements of a typical health care ethics consultation note might reasonably accommodate the needs and expectations of relevant parties, and would therefore include: 1. identification of the relevant ethical issues, questions, or dilemmas; 2. reference to any relevant facts--medical, nursing, social, psychological, spiritual, legal, political, etc.; 3. a prioritized list of recommendations to improve coordinated care; 4. a clear and concise articulation of relevant arguments, wtih specific reference to the list of recommendations as well as to the institution's overall ethos; 5. a contextual statement, identifying the perceived degree of consensus or support for the recommendations …

Diethylene Glycol Distearate (Dgd): A Versatile Embedding Medium For Retinal Cytochemistry, Jun C. Huang, Kristina Mieziewska, Nancy Philp, Theo Van Veen, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

Quantitative Determination Of Surface Excess By The Semiintegral Method, Susanne Dana, Mathew Jablonski, Mark Anderson

Mark R. Anderson

In 1988 Bowling and McCreery reported that the semiintegral of voltammetric data provided an excellent method for the qualitative diagnosis of weak adsortpion of material upon an electrode. This report was important to electroanalytical chemistry because of the difficulty often encountered when trying to identify the presence of weakly adsorbed material and because of the impact that weak adsorption has upon voltammetric response. Many electrochemical analyses are dependent upon the evaluation of voltammetric wave shape, particularly kinetic analyses. Unlike strong adsorption, the presence of weakly adsorbed material does not dramatically and obviously perturb the shape of the voltammetric response; consequently, …

In Loco Parentis: Minimal Risk As An Ethical Threshold For Research Upon Children, Benjamin Freedman, Abraham Fuks, Charles Weijer

Charles Weijer

No abstract provided.

Solid-State Structures Of N-Butyllithium-Tmeda, -Thf, And -Dme Complexes., Michael Nichols, Paul Williard

Michael A Nichols

No abstract provided.

Burnham, Colton, And Pollock Reply, Nancy Burnham, Rj Colton, Hm Pollock

Nancy A. Burnham

It is not necessary to obtain permission to reuse this article or its components as it is available under the terms of the Creative Commons Attribution 3.0 License. This license permits unrestricted use, distribution, and reproduction in any medium, provided attribution to the author (s) and the published article's title, journal citation, and DOI are maintained. Please note that some figures may have been included with permission from other third parties. It is your responsibility to obtain the proper permission from the rights holder

Application Of Square Wave Voltammetry For Electrochemical Detection In Gradient Elution Hplc, John Roush, Mark Anderson

Mark R. Anderson

The utility of square-wave voltammetry with a conventionally sized indicator electrode for use in the detection of gradient elution HPLC applications is demonstrated. A redesigned electrochemical detector cell, based upon a type of wall-jet design, provides more efficient potential control and allows the voltammetric detection. The minimum detectable quantity and linear dynamic range for the new detector design were found to be 13pg and 5 orders of magnitude, respectively, comparable to other electrochemical detectors. In the separation of a test mixture containing hydroquinone. bromohydroquinone, catechol, resorcinol, and phenylhydroquinone baseline resolution of all five components is obtained in 12 minutes using …

Political Crime In Contemporary America: A Critical Approach, Kenneth Tunnell

Kenneth Tunnell

Nine essays explore not only politically motivated crimes against the state, but also harmful acts committed by the government, a category usually omitted in discussions of political crime. Among the topics are social relationships that can be considered criminal but are legal, debunking the "pro-life" agenda, the role of the state in violence against women, and hate crimes and the far right.

Monocyte-Mediated Immunodepression After Acute Ethanol Exposure, Gyongyi Szabo

Gyongyi Szabo

Szabo G. 1993. Monocyte-Mediated Immunodepression after Acute Ethanol Exposure. In Alcohol, Drugs of Abuse and Immunomodulation: proceedings of the 2nd International Conference on Alcohol, Drugs of Abuse and Immunomodulation (AIDS) held in Arizona, USA, on 9-13 September 1992. Advances in Biosciences, Vol. 86. Ed: R.R. Watson, Philadelphia, Pergamon Press, pp. 121-130. ISBN 0080420389, 9780080420387.

Transpacific Vision, Derek Shearer

Derek Shearer

Reviews the book `Turning the Tables: A Machiavellian Strategy for Dealing with Japan,' by Daniel Burstein.

Short-Term Memory (Nature, Contents, Formation, Encoding, Organization), Pennie Seibert

Pennie S. Seibert

No abstract provided.

Physics Students' Understanding Of Relative Speed: A Phenomenographic Study, Eleanor Walsh, Gloria Dall'alba, John Bowden, Elaine Martin, Ference Marton, Geoff Masters, Paul Ramsden, Andrew Stephanou

Prof Geoff Masters AO

It is important that students of physics develop both quantitative and qualitative understanding of physical concepts and principles. Although accuracy and reliability in solving quantitative problems is necessary, a qualitative understanding is required in applying concepts and principles to new problems and in real-life situations. If students are not able to understand what underlies quantitative problem-solving procedures nor interpret the solution in physical terms, it is questionable whether they have developed an adequate understanding of physics. The research reported here is part of a larger phenomenographic study that is concerned with the assessment of physics students' understanding of some basic …

Participation In Science Courses In Senior Secondary School, John Ainley

Dr John Ainley

In previous research, participation in science studies in senior secondary school has been related to both background characteristics of students and to earlier achievements and interests. This paper reports an investigation of participation in combinations of subjects in senior secondary schools in Australia which embody different science orientations. It shows that different combinations of factors shape participation in physical science' and 'biological and other science' types of course. Both are favoured by investigative interest but participation in a physical science course type is strongly associated with high levels of earlier school achievement in numeracy and gender whereas participation in a …

Bidding Till Bankrupt: Destructive Competition In Professional Team Sports, James Whitney

Jim Whitney

Focuses on the destructive competition of professional team sports in the United States. Identification of the team performance criteria; Definition of descriptive competition; Type of contracting arrangement implemented by the league.

Job Security And Work Force Adjustment: How Different Are U.S. And Japanese Practices?, Katharine Abraham, Susan Houseman

Susan N. Houseman

No abstract provided.

Interlacement Of The Even And Odd Spectra Of Real Symmetric Toeplitz Matrices, William F. Trench

William F. Trench

No abstract provided.

Asymptotic Behavior Of Solutions Of Poincar'e Difference Equations, William F. Trench

William F. Trench

No abstract provided.