Digital Commons Network^™

Benefit-Sharing And Other Protections For Communities In Genetic Research, Charles Weijer

Charles Weijer

No abstract provided.

Neal-Schuman Authoritative Guide To Evaluating Information On The Internet, By Alison Cooke: New York, Ny: Neal-Schuman Publishers, Inc., 1999. (Neal-Schuman Netguide Series). Isbn 1-55570-356-9, Elizabeth Parang

Elizabeth Parang

No abstract provided.

Clinical Equipoise And Not The Uncertainty Principle Is The Moral Underpinning Of The Randomised Controlled Trial, Charles Weijer, Stanley Shapiro, Kathleen Glass

Charles Weijer

No abstract provided.

Moral Solutions In Assessing Research Risk, Paul Miller, Charles Weijer

Charles Weijer

No abstract provided.

Protecting Communities In Biomedical Research, Charles Weijer, E. Emanuel

Charles Weijer

Although for the last 50 years, ethicists dealing with human experimentation have focused primarily on the need to protect individual research subjects and vulnerable groups, biomedical research, especially in genetics, now requires the establishment of standards for the protection of communities. We have developed such a strategy, based on five steps. (i) Identification of community characteristics relevant to the biomedical research setting, (ii) delineation of a typology of different types of communities using these characteristics, (iii) determination of the range of possible community protections, (iv) creation of connections between particular protections and one or more community characteristics necessary for its …

Control Of Developmental Timing In Caenorhabditis Elegans, Victor Ambros

Victor R. Ambros

Studies of the nematode Caenorhabditis elegans have identified genetic and molecular mechanisms controlling temporal patterns of developmental events. Mutations in genes of the C. elegans heterochronic pathway cause altered temporal patterns of larval development, in which cells at certain larval stages execute cell division patterns or differentiation programs normally specific for other stages. The products of the heterochronic genes include transcriptional and translational regulators and two different cases of novel small translational regulatory RNAs. Other genes of the pathway encode evolutionarily conserved proteins, including a homolog of the Drosophila Period circadian timing regulator, and a member of the nuclear receptor …

Junk Philosophy Of Science?: The Paradox Of Expertise And Interdisciplinarity In Federal Courts, David Caudill, R. Redding

David S Caudill

No abstract provided.

Caring And Gender (Book Review), Linda Treiber

Linda A. Treiber

Review of the book "Caring and Gender," by Francesca M. Cancian and Stacey M. Oliker.

Review Of Local Economic Development: A Geographical Comparison Of Rural Community Restructuring., Ruth Connell

Ruth R. Connell

No abstract provided.

Precise, Highly Female-Biased Sex Ratios In A Social Spider, Leticia Avilés, John Mccormack, Asher Cutter, Todd Bukowski

John E. McCormack

It has been recognized for some time that the risk of producing maleless clutches should select for a lower than binomial variance in the sex ratio of organisms with female–biased sex ratios, small clutches and breeding groups containing the clutch of a single female. However, to date, precise sex ratios have only been reported for organisms with haplodiploid sex determination, a system which allows direct control of the sex of individual offspring. In contrast, under heterogametic sex determination chance is expected to play a crucial role in determining the sex composition of any one family, in particular when males are …

The Term Structure Of Interest Rates And The Mexican Economy, Jorge Gonzalez, Roger Spencer, Daniel Walz

Jorge Gonzalez

Can the yield spread, which has been found to predict with surprising accuracy the movement of key macroeconomic variables of developed countries, also predict such variables for a developing country experiencing economic turmoil? This article presents empirical results that suggest significant forecasting ability for the yield spread for segments of the Mexican economy during the 1995–1997 period of economic volatility. The actual and predicted variable changes sometimes conflict with those experienced by developed countries in part because of the unusually close relationship between the Mexican Treasury and the Banco de México. Consequently, analysts and policy officials may exploit the forecast …

Weak-Singlet Fermions: Models And Constraints, Marko Popovic, Elizabeth Simmons

Marko B. Popovic

We employ data from precision electroweak tests and collider searches to derive constraints on the possibility that weak-singlet fermions mix with the ordinary standard model fermions. Our findings are presented within the context of a theory with weak-singlet partners for all ordinary fermions and theories in which only third-generation fermions mix with weak singlets. In addition, we indicate how our results can be applied more widely in theories containing exotic fermions.

Regulation Of Cell Growth By Oxidized Ldl., Guy Chisolm, Yuh-Cherng Chai

Yuh-Cherng Chai

The first reports of the influences of oxidized LDL (oxLDL) on cell function pertained to negative effects on cell growth—growth arrest, injury, and toxicity. Since these studies, it has become apparent that sublethal levels of oxLDL cause some, but not all, cells to proliferate. This review highlights the growth-promoting effects of oxLDL rather than its inhibitory or injurious effects. Smooth muscle cells (SMCs) and monocyte-macrophages proliferate after exposure to oxLDL; endothelial cells do not. Scavenger receptors are involved in the proliferative effects on monocyte-macrophages, whereas the effects of oxLDL on SMCs appear to be receptor independent. Lysophosphatidylcholine (lysoPC), and structurally …

The Sum Of My Parts, Charles Weijer

Charles Weijer

No abstract provided.

Radiation Treatment For Cervical Esophagus: Patterns Of Practice Study In Canada, 1996, Patricia Tai, Jake Van Dyk, Edward Yu, Jerry Battista, Matthew Schmid, Larry Stitt, Jon Tonita, Terry Coad

Edward Yu

PURPOSE: To assess the patterns of practice among Canadian radiation oncologists who treat esophageal cancers, using a trans-Canada survey, completed at the end of 1996. METHODS AND MATERIALS: One of 3 case presentations of different stages of cervical esophageal cancer was randomly assigned and sent to participating radiation oncologists by mail. Respondents were asked to fill in questionnaires regarding treatment techniques and to outline target volumes for the boost phase of radiotherapy. Radiation oncologists from 26 of 27 (96%) of all Canadian centers participated. RESULTS: High-energy X-rays (>/= 10 MV) were employed by 68% of the respondents in part …

Economics In Cyberspace: A Comparison Study, Peter Navarro

PETER NAVARRO

No abstract provided.

Nike’S Commercial Solution: Girls, Sneakers, And Salvation, Shelley Lucas

Shelley Lucas

In this article I critically examine the ways in which Nike has situated itself as an active participant in current cultural conversations about girls' and women's participation in sport through three television commercials: `If you let me play', `There's a girl being born in America', and `The Fun Police'. In these advertisements, Nike positions itself as helping girls get a chance to play sports, helping them lead healthier and happier lives, helping them learn the rules of the game, and helping them to have fun. However, I argue that Nike's suggestion that girls can be empowered through sport (and through …

The Church As Counterculture, Michael Budde

Michael Budde

The question, "What does it mean to be 'the church'?" has always been among the most controversial and of vital concern to political, economic, and ecclesial leaders alike. How it is answered influences whether Christianity will be a force for legitimating or subverting existing secular relations of power, influence, and privilege. The Church as Counterculture enters the debates on Christian identity, purpose, and organization by calling for the churches to reclaim their roles as "communities of disciples"-distinct and distinctive groups formed by the priorities and practices of Jesus-to constitute a countercultural reality and challenge to secular society and existing power …

The Mechanic State Of “Inner Tissue” In The Growing Zone Of Sunflower Hypocotyls And The Regulation Of Its Growth Rate Following Excision, Winfried Peters, A. Tomos

Winfried S. Peters

A Changing Bridge For Changing Times: The History Of The West Boston Bridge, 1793-1907, Dale H. Freeman

Dale H. Freeman

Master of Arts Thesis, June 2000: This thesis examines the construction in 1793 of the West Boston Bridge, the first bridge to span the Charles River between Boston and Cambridge, and its successors at the same location in 1854 and then 1907 (the Longfellow Bridge). It is a study of the impact of these bridges on the commercial development and urban settlement patterns of both Cambridge and Boston, and it sets the construction of each bridge in the historical context of the period in which each was built. The thesis utilizes a variety of primary sources drawn from the Cambridge …

A Homeostatic Set Point For Branching In Neurospora Crassa, Michael Watters, Christine Humphries, Ingrid De Vries, Anthony Griffiths

Michael Watters

The mechanisms responsible for controlling hyphal extension and branching are still poorly understood. We have investigated these processes by studying their dependence on temperature and nutrient concentration. Tip growth is highly responsive to temperature change, increasing linearly from 4 to 37 °C. Over this range of temperatures the branching pattern shows virtually no response. Likewise, varying nutrient concentration does not affect branch distribution. Colonies subjected to rapid extreme temperature downshifts (for example from 25 to 4°) display a strong and highly predictable branching response. There are three stages to this response. First there is an initial lag phase of growth …

Functional Infrared Imaging Of The Breast, J. Keyserlingk, P. Ahlgren, E. Yu, N. Belliveau, M. Yassa

Edward Yu

In order to re-assess the potential contribution of infrared (IR) imaging as a first-line component of a multi-imaging strategy using currently available technology, we first review the history of its introduction and clinical application, including the results of the Breast Cancer Detection Demonstration Projects (BCDDP). We then discuss experiments with a new high-resolution, computerized IR station and software program acquired by the Ville Marie Breast Center to assess IR imaging's ability to complement clinical examination and mammography in the early detection of breast cancer. Our goal is to show that high-resolution IR imaging provides additional safe, practical, and objective information …

Badi‘A Masabni, Artiste And Modernist: The Egyptian Print Media’S Carnival Of National Identity, Roberta Dougherty

Robin Dougherty

Fuzzy Neural Network Models For Classification, Arun D. Kulkarni, Charles D. Cavanaugh

Arun Kulkarni

Bioethics: An Anthology, Charles Weijer

Charles Weijer

No abstract provided.

An Historical Take On The Physician's Charter, Nuala Kenny, Charles Weijer

Charles Weijer

No abstract provided.

The Spectral Function Of A Composite From Reflectance Data., Anthony Day, M. Thorpe, A. Grant, A. Sievers

Anthony Roy Day

In the Bergman-Milton spectral representation for the effective dielectric constant of a composite all relevant geometric information is captured in a spectral function that is independent of material properties. We present numerical simulations of the reflectance of a model two component composite, where both components have temperature-dependant dielectric resonances, and show that the spectral function can be extracted from the data. The same spectral function is obtained from simulation data corresponding to different temperatures but the resolution depends on the width of the resonance line and is greatest at low-temperatures.

The Lin-41 Rbcc Gene Acts In The C. Elegans Heterochronic Pathway Between The Let-7 Regulatory Rna And The Lin-29 Transcription Factor, Frank Slack, Michael Basson, Zhongchi Liu, Victor Ambros, H. Horvitz, Gary Ruvkun

Victor R. Ambros

Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of adult fates at larval stages. Increased lin-41 activity causes the opposite phenotype, reiteration of larval fates. let-7 mutations cause similar reiterated heterochronic phenotypes that are suppressed by lin-41 mutations, showing that lin-41 is negatively regulated by let-7. lin-41 negatively regulates the timing of LIN-29 adult specification transcription factor expression. lin-41 encodes an RBCC protein, and two elements in the lin-413'UTR are complementary to the 21 nucleotide let-7 regulatory RNA. A lin-41::GFP fusion gene is downregulated in the tissues affected by lin-41 at the time that the let-7 …

Xenopus Laevis Gelatinase B (Xmmp-9): Development, Regeneration, And Wound Healing, Brian Walter, Maria Carinato, Jonathan Henry

Brian Walter

It has been argued that matrix metalloproteinases play important roles in cellular differentiation and regeneration in certain systems. While studying changes in gene expression associated with the phenomena of cornea/lens transdifferentiation ("lens regeneration"), which takes place in the larva of Xenopus laevis, we identified the Xenopus gelatinase B gene. The open reading frame is homologous to other gelatinase B genes identified in other species and encodes all of the domains characteristic of this protein. Xenopus gelatinase B (Xmmp-9) is first expressed during early tail-bud stages in a subset of mesodermal cells scattered throughout the body. Expression is also seen in …

Correspondence, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

No abstract provided.