Digital Commons Network^™

Federal Forfeiture: Law, Policy And Practice, Greg Warchol, Dennis Payne, Brian Johnson

Greg Warchol

The purpose of this research is to first describe the origins and current state of federal asset forfeiture law, then examine of how property seized under the forfeiture laws for drug law violations is proceeded against by the federal government. The methodology, which is primarily exploratory, utilizes both qualitative and quantitative data. A sample of over 6000 federal administrative and judicial drug forfeiture cases are described and analyzed to construct a profile of the federal government's use of this policy. Findings raise questions about the use of forfeiture and the government's intent. Implications and suggestions for future research are included.

The Lin-4 Regulatory Rna Controls Developmental Timing In Caenorhabditis Elegans By Blocking Lin-14 Protein Synthesis After The Initiation Of Translation, Philip Olsen, Victor Ambros

Victor R. Ambros

lin-4 encodes a small RNA that is complementary to sequences in the 3' untranslated region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of LIN-14 protein. This repression is essential for the proper timing of numerous events of Caenorhabditis elegans larval development. We have investigated the mechanism of lin-4 RNA action by examining the fate of lin-14 mRNA in vivo during the time that lin-4 RNA is expressed. Our results indicate that the rate of synthesis of lin-14 mRNA, its state of polyadenylation, its abundance in the cytoplasmic fraction, and its polysomal sedimentation profile do not …

The Influence Of Technology Strategy On Initial Public Offering Performance (Ipo), Post-Ipo Enterprise Performance, And Long-Term Survival In High-Technology Firms, Anthony Wilbon

Anthony Wilbon

Welfare Reform A Success?, Laura Stivers

Laura Stivers

Fuzzy Neural Network Models For Supervised Classification: Multispectral Image Analysis, Arun D. Kulkarni, Kamlesh Lulla

Arun Kulkarni

No abstract provided.

What's The Price Of A Research Subject?, Charles Weijer

Charles Weijer

No abstract provided.

Time Course And Temporal Order Of Changes In Movement Kinematics During Learning Of Fast And Accurate Elbow Flexions, D. Flament, M. Shapiro, T. Kempf, D. Corcos

Timothy Kempf

Learning of a motor task, such as making accurate goal-directed movements, is associated with a number of changes in limb kinematics and in the EMG activity that produces the movement. Some of these changes include increases in movement velocity, improvements in end-point accuracy, and the development of a biphasic/triphasic EMG pattern for fast movements. One question that has remained unanswered is whether the time course of the learning-related changes in movement parameters is similar for all parameters. The present paper focuses on this question and presents evidence that different parameters evolve with a specific temporal order. Neurologically normal subjects were …

Analysis Of Age And Growth In Two Eastern Pacific Groupers (Serranidae: Epinephelinae), Matthew Craig, Daniel Pondella, John Hafner

Daniel Pondella

In an attempt to characterize species specific-growth rates of two Eastern Pacific groupers, individuals from two sympatric species, Epinephelus labriformis (n = 173), and Cephalopholis panamensis (n = 127), were collected at various localities in Mexico and the Galápagos archipelago in 1997 and 1998. Sagittal otoliths were removed, and age of each individual was determined by direct visual inspection of annuli present following sectioning. Length/weight relationships were determined, and growth curves were generated using the von Bertalanffy growth model. The two species demonstrated similar growth rates, yet, as determined by the von Bertalanffy parameters, E. labriformis tended towards a larger …

Thinking Clearly About Research Risk: Implications Of The Work Of Benjamin Freedman, Charles Weijer

Charles Weijer

No abstract provided.

Protecting Communities In Research: Current Guidelines And Limits Of Extrapolation, Charles Weijer, Gary Goldsand, Ezekiel Emanuel

Charles Weijer

As genetic research increasingly focuses on communities, there have been calls for extending research protections to them. We critically examine guidelines developed to protect aboriginal communities and consider their applicability to other communities. These guidelines are based on a model of researcher-community partnership and span the phases of a research project, from protocol development to publication. The complete list of 23 protections may apply to those few non-aboriginal communities, such as the Amish, that are highly cohesive. Although some protections may be applicable to less-cohesive communities, such as Ashkenazi Jews, analysis suggests substantial problems in extending these guidelines in toto …

The Correlation Of Profiles Of Surface Ph And Elongation Growth In Maize Roots, Winfried Peters, Hubert Felle

Winfried S. Peters

Phase Imaging: Deep Or Superficial?, Nancy Burnham, O Behrend, L Odoni, J Loubet

Nancy A. Burnham

Phase images acquired while intermittently contacting a sample surface with the tip of an atomic force microscope cantilever are not easy to relate to material properties. We have simulated dynamic force curves and compared simulated with experimental results. For some cantilever–sample combinations, the interaction remains a surface effect, whereas for others, the tip penetrates the sample significantly. Height artifacts in the “topography” images, and the role of the sample stiffness, work of adhesion, damping, and topography in the cantilever response manifest themselves to different extents depending on the indentation depth.

Action Of Repeat-Induced Point Mutation On Both Strands Of A Duplex And On Tandem Duplications Of Various Sizes In Neurospora, Michael Watters, Thomas Randall, Brian Margolin, Eric Selker, David Stadler

Michael Watters

In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets of strains. First, we examined the products of a presumptive spontaneous RIP event at the mtr locus. Results of sequencing suggested that a single RIP event produces two distinct patterns of change, descended from the two strands of an affected DNA duplex. Equivalent results were obtained using an exceptional tetrad from …

Optimal Photon Energies For Iudr K-Edge Radiosensitization With Filtered X-Ray And Radioisotope Sources, S. Karnas, E. Yu, R. Mcgarry, J. Battista

Edward Yu

The purpose of this work is to determine the most physically effective radiation energy for K-edge absorption of x- or gamma-rays by iododeoxyuridine (IUdR) on Chinese hamster ovary (CHO) cells. Brachytherapy sources (Sm-145, I-125, Yb-169 and Am-241) and x-ray beams (30 kVp, 100 kVp and 100 kVp with gold, gadolinium, lead or tungsten filtration) were investigated for their preferential absorption qualities by IUdR sensitized DNA. The 30 kVp, 100 kVp and 100 kVp with tungsten filtration were then used to irradiate CHO cells, with or without IUdR incorporation (i.e. 10(-5) M of IUdR for 3 days). Radiation absorption calculations were …

The Power Of Cyberlearning: An Empirical Test, Peter Navarro

PETER NAVARRO

No abstract provided.

Protecting Communities In Research: Philosophical And Pragmatic Challenges, Charles Weijer

Charles Weijer

The issue of the protection of communities in clinical research first arose 10 years ago in studies conducted in technologically developing countries by scientists from technologically developed nations. The question was, which ethical standards ought to apply, those of the Western investigators or local standards?

Evaluation Of Cgmp-Phosphodiesterase (Pde) Subunits For Causal Association With Rod–Cone Dysplasia 2 (Rcd2), A Canine Model Of Abnormal Retinal Cgmp Metabolism, Weiquan Wang, Gregory Acland, Kunal Ray, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Environmentally Sustainable Economic Development, Asayehgn Desta

Asayehgn Desta

Synthesis And Release Of Docosahexaenoic Acid By The Rpe Cells Of Prcd-Affected Dogs, Huiming Chen, Jharna Ray, Virginia Scarpino, Gregory M. Acland, Gustavo D. Aguirre, Robert E. Anderson

Gustavo D. Aguirre, VMD, PhD

Voting Ourselves Rights: A Critique Of The Canadian Medical Association Charter For Physicians, Nuala Kenny, Charles Weijer, Francoise Baylis

Charles Weijer

No abstract provided.

Getting Doctors To Listen: Ethics And Outcomes Data In Context, Charles Weijer

Charles Weijer

No abstract provided.

A Novel Retinal Degeneration Locus Identified By Linkage And Comparative Mapping Of Canine Early Retinal Degeneration, Gregory Acland, Kunal Ray, Cathryn Mellersh, Amelia Langston, Jasper Rine, Elaine Ostrander, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Another Tuskegee?, Charles Weijer

Charles Weijer

No abstract provided.

Enhanced Mathematics Learning: Does Technology Make A Difference?, Katherine Dix

Dr Katherine Dix

The Timing Oflin-4rna Accumulation Controls The Timing Of Postembryonic Developmental Events Incaenorhabditis Elegans, Rhonda Feinbaum, Victor Ambros

Victor R. Ambros

The lin-4 gene encodes a small RNA that is required to translationally repress lin-14 toward the end of the first larval stage of Caenorhabditis elegans development. To determine if the timing of LIN-14 protein down-regulation depends on the temporal profile of lin-4 RNA level, we analyzed the stage-specificity of lin-4 RNA expression during wild-type development and examined the phenotypes of transgenic worms that overexpress lin-4 RNA during the first larval stage. We found that lin-4 RNA first becomes detectable at approximately 12 h of wild-type larval development and rapidly accumulates to nearly maximum levels by 16 h. This profile of …

Comparative Morphology. Verb Taxonomy In Indonesian, Tagalog And Dutch: Jan Voskuil, Holland Institute Of Generative Linguistics 21, 1996, Ileana Paul

Ileana Paul

No abstract provided.

Cell Cycle-Dependent Sequencing Of Cell Fate Decisions In Caenorhabditis Elegans Vulva Precursor Cells, Victor Ambros

Victor R. Ambros

In Caenorhabditis elegans, the fates of the six multipotent vulva precursor cells (VPCs) are specified by extracellular signals. One VPC expresses the primary (1 degrees ) fate in response to a Ras-mediated inductive signal from the gonad. The two VPCs flanking the 1 degrees cell each express secondary (2 degrees ) fates in response to lin-12-mediated lateral signaling. The remaining three VPCs each adopt the non-vulval tertiary (3 degrees ) fate. Here I describe experiments examining how the selection of these vulval fates is affected by cell cycle arrest and cell cycle-restricted lin-12 activity. The results suggest that lin-12 participates …

The Correlation Of Physical Properties Of Organic Molecules With Computed Molecular Surface Areas., Robert Mebane, Shannon Schanley, Thomas Rybolt, Chrystal Bruce

Chrystal D. Bruce

The objective of this paper is to show that a student's understanding of molecular properties can be enhanced with the study of molecular surface areas obtained from readily available molecular modeling software.

Xet-Related Genes And Growth Kinematics In Barley Leaves, Winfried Peters, Wieland Fricke, Peter Chandler

Winfried S. Peters

Women, Work, And Wages, Laura Stivers

Laura Stivers