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1997

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Guilty Property: A Qualitative Analysis Of Civil Forfeiture, Brian Johnson, Greg Warchol Apr 2014

Guilty Property: A Qualitative Analysis Of Civil Forfeiture, Brian Johnson, Greg Warchol

Greg Warchol

The objective of this article is to explore how property seized under the federal civil-judicial forfeiture laws for drug law violations is proceeded against by the government. The methodology is primarily exploratory. A sample of federal civil-judicial drug forfeiture cases is described and then analyzed in regard to the relative importance of the cases’ characteristics. The findings raise serious questions about the use of this policy and the government’s intent behind forfeiture. Implications and suggestions for future research are also presented.


A Linkage Map Of The Canine Genome, Cathryn Mellersh, Amelia Langston, Gregory Acland, Melissa Fleming, Kunal Ray, Neil Weigand, Leigh Francisco, Mark Gibbs, Gustavo Aguirre, Elaine Ostrander Dec 1997

A Linkage Map Of The Canine Genome, Cathryn Mellersh, Amelia Langston, Gregory Acland, Melissa Fleming, Kunal Ray, Neil Weigand, Leigh Francisco, Mark Gibbs, Gustavo Aguirre, Elaine Ostrander

Gustavo D. Aguirre, VMD, PhD

A genetic linkage map of the canine genome has been developed by typing 150 microsatellite markers using 17 three-generation pedigrees, composed of 163 F2individuals. One hundred and thirty-nine markers were linked to at least one other marker with a lod score ≥ 3.0, identifying 30 linkage groups. The largest chromosome had 9 markers spanning 106.1 cM. The average distance between markers was 14.03 cM, and the map covers an estimated 2073 cM. Eleven markers were informative on the mapping panel, but were unlinked to any other marker. These likely represent single markers located on small, distinct canine chromosomes. This map …


Construction Of A Panel Of Canine–Rodent Hybrid Cell Lines For Use In Partitioning Of The Canine Genome, Amelia A. Langston, Cathryn S. Mellersh, Cassandra L. Neal, Kunal Ray, Gregory M. Acland, Mark Gibbs, Gustavo D. Aguirre, R.E. K. Fournier, Elaine A. Ostrander Dec 1997

Construction Of A Panel Of Canine–Rodent Hybrid Cell Lines For Use In Partitioning Of The Canine Genome, Amelia A. Langston, Cathryn S. Mellersh, Cassandra L. Neal, Kunal Ray, Gregory M. Acland, Mark Gibbs, Gustavo D. Aguirre, R.E. K. Fournier, Elaine A. Ostrander

Gustavo D. Aguirre, VMD, PhD

We have constructed a collection of canine–rodent microcell hybrid cell lines by fusion of canine fibroblast microcell donors with immortalized rodent recipient cells. Characterization of the hybrid cell lines using a combination of fluorescencein situhybridization and PCR analysis of canine microsatellite repeat sequences allowed selection of a panel of hybrids in which most canine chromosomes are represented. Approximately 90% of genetic markers and genes that were tested could be assigned to 1 of 31 anonymous canine chromosome groups, based on common patterns of retention in the hybrid set. Many of these putative chromosome groups have now been validated …


Storage For Good Times And Bad: Of Rats And Men, Ted Bergstrom Nov 1997

Storage For Good Times And Bad: Of Rats And Men, Ted Bergstrom

Ted C Bergstrom

How do rats and squirrels decide how much to hoard for the winter when they do not know how long the winter will be? This paper argues that natural selection is likely to result in random differences in the attitudes toward systemic risk by genetically identical individuals.


Saints, Sinners, And Affirmative Action, Peter Dreier, Regina Freer Oct 1997

Saints, Sinners, And Affirmative Action, Peter Dreier, Regina Freer

Regina Freer

No abstract provided.


The Placebo Effect, Charles Weijer Oct 1997

The Placebo Effect, Charles Weijer

Charles Weijer

No abstract provided.


Cloning And Conservation Of Biological Diversity: Paradox, Panacea, Or Pandora's Box?, Shaily Menon, Kamaljit Bawa, Leah Gorman Jul 1997

Cloning And Conservation Of Biological Diversity: Paradox, Panacea, Or Pandora's Box?, Shaily Menon, Kamaljit Bawa, Leah Gorman

Shaily Menon

The success of a Scottish team in cloning a mammal from an adult tissue cell has generated considerable speculation in the popular press about potential applications to conservation biology. Possibilities that have been mentioned include cloning endangered species and creating gene banks for the germplasm of rare species. Sensational or inaccurate reports might encourage the mistaken notion that cloning technology is more advanced or reliable than it actually is. More important, such reports might foster the myth that there is no longer an urgency to conserve endangered species or their habitats as long as we have frozen germplasm and cloning …


Canine Rod Photoreceptor Cgmp-Gated Channel Protein Α-Subunit: Studies On The Expression Of The Gene And Characterization Of The Cdna, Qi Zhang, Sue Pearce-Kelling, Gregory Acland, Gustavo Aguirre, Kunal Ray Jul 1997

Canine Rod Photoreceptor Cgmp-Gated Channel Protein Α-Subunit: Studies On The Expression Of The Gene And Characterization Of The Cdna, Qi Zhang, Sue Pearce-Kelling, Gregory Acland, Gustavo Aguirre, Kunal Ray

Gustavo D. Aguirre, VMD, PhD

Rod photoreceptor cyclic GMP gated-channel protein is a key component of the visual transduction cascade in the vertebrate retina. The protein is composed of at least two subunits (α and β). Mutations in the α-subunit (CNGC1) have been shown to cause retinitis pigmentosa (RP) in humans. Several heterogeneous canine retinal diseases, which are clinically similar to RP, are known collectively as progressive retinal atrophy (PRA) and occur in dogs in a breed-specific manner. For the purpose of examining CNGC1 gene as a candidate for PRA, we report here the characterization of canine CNGC1 cDNA, and examine the expression of the …


Wounding-Induced Cell Wall Ph Shifts In Coleoptile Segments Of Various Poaceae, Winfried Peters Jul 1997

Wounding-Induced Cell Wall Ph Shifts In Coleoptile Segments Of Various Poaceae, Winfried Peters

Winfried S. Peters

Wounding-induced extracellular pH shifts were characterized previously in excised segments of maize (Zea mays L.) coleoptiles. In the present study it is demonstrated that similar pH shifts also occur in Triticum aestivum L., Secale cereale L., Hordeum vulgare L., Avena sativa L., Sorghum durra (Forsk.) Stapf, and Setaria italica (L.) Beauv., with characteristic quantitative differences between the species. Indole-acetic acid induces pronounced drops of the medium pH in all species except Setaria italica.


Iaa Breakdown And Its Effect On Auxin-Induced Cell Wall Acidification In Maize Coleoptile Segments, Winfried Peters, Christa Lommel, Hubert Felle Jun 1997

Iaa Breakdown And Its Effect On Auxin-Induced Cell Wall Acidification In Maize Coleoptile Segments, Winfried Peters, Christa Lommel, Hubert Felle

Winfried S. Peters

In excised Zea mays L. coleoptiles incubated in aerated media at high fresh weight per volume ratios, indole-3-acetic acid induces transient drops of extracellular pH. Based on the quantitative dependency of the response on the initial auxin concentration we developed a novel auxin bioassay, which allows reliable estimation of IAA concentrations between 10−8.5 and 10−5 M. Using the bioassay and complementary concentration measurements by IAA fluorescence we found the transient IAA-induced pH response paralleled by a decrease of auxin activity and concentration in the medium. This decline is rapid and starts immediately upon auxin addition, and insofar differs from the …


Thermodynamics Of Oligoarginines Binding To Rna And Dna., David Mascotti, Timothy Lohman Jun 1997

Thermodynamics Of Oligoarginines Binding To Rna And Dna., David Mascotti, Timothy Lohman

David P. Mascotti

These results suggest that hydrogen bonding of arginine to the phosphate backbone of the nucleic acids contributes to the increased stability of these complexes.


Duty And Healing: The Lifework Of Benjamin Freedman, Charles Weijer May 1997

Duty And Healing: The Lifework Of Benjamin Freedman, Charles Weijer

Charles Weijer

BENJAMIN FREEDMAN, un des plus grands bioéthiciens du Canada et universitaire re- connu sur la scène internationale, est mort le 20 mars 1997. Professeur de médecine à l’Université McGill de Montréal, Freedman a beaucoup contribué au domaine de la bioéthique, où il a fait notamment des travaux fondamentaux sur le consentement éclairé et la compétence. Dans le domaine de l’éthique de la recherche, Freedman est l’auteur du concept de l’équivalence clinique comme condition préalable à l’exécution éthique de recherches cliniques. Des travaux subséquents ont clarifié l’analyse éthique du risque et les limites du risque permis- sible en recherche sur les …


Differential Expression Of Photoreceptor-Specific Proteins During Disease And Degeneration In The Progressive Rod-Cone Degeneration (Prcd) Retina, Kathryn Gropp, Jun Huang, Gustavo Aguirre May 1997

Differential Expression Of Photoreceptor-Specific Proteins During Disease And Degeneration In The Progressive Rod-Cone Degeneration (Prcd) Retina, Kathryn Gropp, Jun Huang, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Progressive rod-cone degeneration (prcd) is a late-onset hereditary retinal degeneration characterized by normal development of photoreceptors prior to degeneration and death of visual cells. We reported previously that expression of opsin mRNA and protein decreases prior to visual cell degeneration. To examine the specificity of this reduction, we have used immunocytochemistry to correlate photoreceptor-specific protein expression with visual cell disease progression. Eyes from light-adapted age-matched control andprcd-affected dogs were fixed in paraformaldehyde, embedded in diethylene glycol distearate (DGD) wax, and reacted with antibodies specific to interphotoreceptor retinoid-binding protein (IRBP), S-antigen, opsin, phosducin, γ-phosphodiesterase (γ-PDE), and β1-transducin. While IRBP expression did …


Superior Vena Cava Obstruction In Small-Cell Lung Cancer, Roscoe Chan, A. Dar, Edward Yu, Larry Stitt, Francis Whiston, Pauline Truong, Mark Vincent, Walter Kocha May 1997

Superior Vena Cava Obstruction In Small-Cell Lung Cancer, Roscoe Chan, A. Dar, Edward Yu, Larry Stitt, Francis Whiston, Pauline Truong, Mark Vincent, Walter Kocha

Edward Yu

PURPOSE: To identify prognostic or treatment factors influencing the response of superior vena cava obstruction (SVCO), time to SVCO recurrence, and overall survival of SCLC patients with SVCO at presentation; and to assess the role of retreatment in patients with SVCO at recurrent or persistent disease. METHODS AND MATERIALS: Between January 1983 and November 1993, 76 consecutive patients who had small-cell lung cancer (SCLC) with SVCO were treated in our institution. Analysis was done according to the disease status at diagnosis of SVCO. The first analysis concerned a group of 50 patients who had SVCO at initial presentation. The second …


Spilker's Guide To Clinical Trials On Cd-Rom, Charles Weijer May 1997

Spilker's Guide To Clinical Trials On Cd-Rom, Charles Weijer

Charles Weijer

No abstract provided.


Remembering Benjamin Freedman (1951-1997), Françoise Baylis, Charles Weijer Apr 1997

Remembering Benjamin Freedman (1951-1997), Françoise Baylis, Charles Weijer

Charles Weijer

No abstract provided.


Timing And Extent Of Late Quaternary Paleolakes In The Trans-Pecos Closed Basin, West Texas And South-Central New Mexico, David Wilkins, Donald Currey Apr 1997

Timing And Extent Of Late Quaternary Paleolakes In The Trans-Pecos Closed Basin, West Texas And South-Central New Mexico, David Wilkins, Donald Currey

David E. Wilkins

The Trans-Pecos Closed Basin is a hydrographically closed region covering 20,000 km centered on Salt Basin, 160 km east of El Paso, Texas. Geomorphic and limnetic evidence have been used to identify four major highstands for Lake King during the last glacial maximum (LGM). Additional geomorphic features from a second, recently identified, paleolake, Lake Sacramento, have been found in the Beargrass subbasin, a nested subbasin approximately 75 km northwest of Salt Basin. Radiocarbon ages of the organic material in Lake King sediments date four abrupt climate changes and rapid lacustrine transgressions during the LGM with a quasi-periodicity of 2000 yr. …


Selecting Subjects For Participation In Clinical Research: An Empirical Inquiry And Ethical Analysis, Charles Weijer Apr 1997

Selecting Subjects For Participation In Clinical Research: An Empirical Inquiry And Ethical Analysis, Charles Weijer

Charles Weijer

Procedures for the selection of subjects for participation in randomized clinical trials--usually formalized as eligibility criteria in the study protocol--have both scientific and ethical implications. In this thesis, I undertake an examination of eligibility criteria at three stages in the genesis and dissemination of medical knowledge: clinical trial protocol, interpretation by investigators, and reporting of study results.

In the first chapter, ethical issues in subject selection are reviewed and the main study questions are presented. In the second chapter, the results of an examination of eligibility criteria in two sets of clinical trials, one sponsored by the NSABP, the other …


The Human Radiation Experiments: Final Report Of The Advisory Committee On Human Radiation Experiments, Charles Weijer Apr 1997

The Human Radiation Experiments: Final Report Of The Advisory Committee On Human Radiation Experiments, Charles Weijer

Charles Weijer

No abstract provided.


Bioethics For Clinicians: 10. Research Ethics, Charles Weijer, Bernard Dickens, Eric Meslin Apr 1997

Bioethics For Clinicians: 10. Research Ethics, Charles Weijer, Bernard Dickens, Eric Meslin

Charles Weijer

Medical research involving human subjects raises complex ethical, legal and social issues. Investigators sometimes find that their obligations with respect to a research project come into conflict with their obligations to individual patients. The ethical conduct of research rests on 3 guiding principles: respect for persons, beneficience, and justice. Respect for persons underlies the duty to obtain informed consent from study participants. Beneficence demands a favourable balance between the potential benefits and harms of participation. Justice requires that vulnerable people not be exploited and that eligible candidates who may benefit from participation not be excluded without good cause. Studies must …


The Determination Of Relative Elemental Growth Rate Profiles From Segmental Growth Rates (A Methodological Evaluation), Winfried Peters, Nirit Bernstein Mar 1997

The Determination Of Relative Elemental Growth Rate Profiles From Segmental Growth Rates (A Methodological Evaluation), Winfried Peters, Nirit Bernstein

Winfried S. Peters

Relative elemental growth rate (REGR) profiles describe spatial patterns of growth intensity; they are indispensable for causal growth analyses. Published methods of REGR profile determination from marking experiments fall in two classes: the profile is either described by a series of segmental growth rates, or calculated as the slope of a function describing the displacement velocities of points along the organ. The latter technique is usually considered superior for theoretical reasons, but to our knowledge, no comparative methodological study of the two approaches is currently available. We formulated a model REGR profile that resembles those reported from primary roots. We …


Two-Photon Optogalvanic Spectra Of Argon: Odd Parity Rydberg States, Naveed Piracha, M. Baig, S. Khan, B. Suleman Mar 1997

Two-Photon Optogalvanic Spectra Of Argon: Odd Parity Rydberg States, Naveed Piracha, M. Baig, S. Khan, B. Suleman

Naveed K. Piracha

Extensive new data on the odd-parity, single-colour, two-photon optogalvanic spectra of argon in the visible region is reported using an excimer-pumped dye laser in conjunction with an argon discharge cell. The experimental technique enables us to record a pure two-photon spectrum in a region which is dominated by one-photon transitions. A large number of two-photon transitions, originating from the two metastable states [...] and [...] to the excited states of configurations [...] (J=0, 2) and [...] (J = 0 - 4) of argon, has been recorded and arranged into 10 Rydberg series. The interchannel interactions among the [...] and the …


Full House: The Spread Of Excellence From Plato To Darwin, Charles Weijer Mar 1997

Full House: The Spread Of Excellence From Plato To Darwin, Charles Weijer

Charles Weijer

No abstract provided.


Africa And The New World Order, Andrew Ewoh Feb 1997

Africa And The New World Order, Andrew Ewoh

Andrew I.E. Ewoh

What is the plight of Africa under the New World Order? The paper argues that the NWO poses severe economic problems for African nations. It offers two main practical solutions for these problems and plausible policy implications. The analysis concludes by acknowledging that structural adjustment programs as traditionally suggested by the International Monetary Fund and democratization of the polity will not guarantee economic prosperity for the continent.


Impact Of Radiation Therapy Fraction Size On Local Control Of Early Glottic Carcinoma, Edward Yu, George Shenouda, Marie Beaudet, Martin Black Jan 1997

Impact Of Radiation Therapy Fraction Size On Local Control Of Early Glottic Carcinoma, Edward Yu, George Shenouda, Marie Beaudet, Martin Black

Edward Yu

Purpose: Different radiotherapy fractionation schedules were used over a 10-year period to treat patients with early squamous cell carcinoma of the vocal cords at McGill University. A retrospective analysis was performed to study the effect of fraction size on local control in this group of patients. Methods and materials: A total of 126 previously untreated patients with T1 invasive squamous cell carcinoma of the true vocal cords were irradiated between January 1978 and December 1988 in the Department of Radiation Oncology at McGill University. All patients received megavoltage irradiation, 94 patients received daily fractions > 2 Gy (64 patients received 50 …


Infinite Reflections In Pale Fire: The Danish Connection (Hans Andersen And Isak Dinesen), Priscilla Meyer, Jeff Hoffman Jan 1997

Infinite Reflections In Pale Fire: The Danish Connection (Hans Andersen And Isak Dinesen), Priscilla Meyer, Jeff Hoffman

Priscilla Meyer

No abstract provided.


The Voltammetry Of Sc3@C82, Mark Anderson, Harry Dorn, Paul Burbank, Steven Stevenson, James Gibson Jan 1997

The Voltammetry Of Sc3@C82, Mark Anderson, Harry Dorn, Paul Burbank, Steven Stevenson, James Gibson

Mark R. Anderson

Many endohedral metallofullerenes have a C82 cage surrounding the metals, even though the normal arc-vaporization method of fullerene preparation does not generate C82 in significant abundance.1-10Manolopous et al.11-13attribute the low abundance of empty-cage C82 to the unfavorable electron configuration of this species. Consequently, the prevalence of C82 in metallofullerenes may be the result of an electron transfer from the encapsulated metal atoms to the fullerene cage.10-13 The extent of this charge transfer also contributes to the properties (e.g. catalytic, superconductive, nonlinear optical, and ferromagnetic) that are attributed to the endohedral metallofullerenes.14,15Because of the importance of the charge transfer reaction, characterization …


Heterochronic Genes, Victor Ambros Dec 1996

Heterochronic Genes, Victor Ambros

Victor R. Ambros

This chapter focuses on our current understanding of the C. elegans heterochronic gene pathway as determined by genetic characterization of the regulatory interactions among the genes (Ambros and Horvitz 1987; Ambros 1989; Liu and Ambros 1989) and recent progress on the cloning, sequencing, and molecular analysis of genes involved in this pathway (Ruvkun et al. 1989; Arasu et al. 1991; Papp et al. 1991; Wightman et al. 1991; Lee et al. 1993; Rougvie and Ambros 1995; E. Moss et al., in prep). Primary emphasis is placed on the developmental decisions controlled by the heterochronic genes, the regulatory interactions among genes …


Root-Soil Contact For The Desert Succulent Agave Deserti Engelm. In Wet And Drying Soil, Gretchen North, P. Nobel Dec 1996

Root-Soil Contact For The Desert Succulent Agave Deserti Engelm. In Wet And Drying Soil, Gretchen North, P. Nobel

Gretchen North

To investigate the extent and size of root-soil air gaps that develop during soil drying, resin casts of roots of the desert succulent Agave deserti Engelm. were made in situ for container-grown plants and in the field. Plants that were droughted in containers for 7 and 14 d had 24 and 34% root shrinkage, respectively, leading to root-soil air gaps that would reduce the hydraulic conductivity at the root-soil interface by a factor of about 5. When containers were vibrated during drought, root-soil air gaps were greatly diminished, and the predicted conductivity at the interface was similar to that of …


The Crispus Attucks Monument Dedication, Dale Freeman Dec 1996

The Crispus Attucks Monument Dedication, Dale Freeman

Dale H. Freeman

The story of the Crispus Attucks Monument on the Boston Common, dedicated in November, 1888.