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Nitrogenase Substrates As Intercluster Bridging Units Between The Molybdenum Atoms In Doubly Bridged, Double Cubanes. The Synthesis And Characterization Of The [Mofe3s4cl2(Cl4cat)]2(.Mu.2-S)(.Mu.2-L)]N- Anions (L = N2h4, N = 4; L = Cn-, N = 5), Paul Challen, Sang Koo, C. Kim, W. Dunham, D. Coucouvanis

Paul R. Challen

No abstract provided.

Intravascular Metabolism Of Normal And Mutant Mouse Immunoglobulin Molecules, Roberta Pollock, Deborah French, Joshua Metlay, Barbara Birshtein, Matthew Scharff

Roberta Pollock

The metabolism of IgG immunoglobulins in the body is tightly regulated in order to maintain their intravascular concentration. Different subclasses may have different intravascular half-lives, and in the mouse, passively administered IgG2b disappears from the circulation more rapidly than IgG2a. We have attempted to localize the sequences in the constant region which are responsible for this difference by examining the intravascular metabolism of mutant immunoglobulins that were generated in tissue culture and have undergone deletions of individual constant region domains or contain different combinations of γ2b and γ2a CH2 and CH3 domains. Our results suggest that the regulation of intravascular …

On The Electrochemical Etching Of Tips For Scanning Tunneling Microscopy, Nancy Burnham, J. Ibe, P. Bey Jr., S. Brandow, R. Brizzolara, D. Dilella, K. Lee, C. K. Marrian, R. Colton

Nancy A. Burnham

The sharpness of tips used in scanning tunneling microscopy(STM) is one factor which affects the resolution of the STM image. In this paper, we report on a direct‐current (dc) drop‐off electrochemicaletching procedure used to sharpen tips for STM. The shape of the tip is dependent on the meniscus which surrounds the wire at the air–electrolyte interface. The sharpness of the tip is related to the tensile strength of the wire and how quickly the electrochemical reaction can be stopped once the wire breaks. We have found that the cutoff time of the etch circuit has a significant effect on the …

Β-Glucuronidase Mediated Pathway Essential For Retinal Pigment Epithelial Degradation Of Glycosaminoglycans. Disease Expression And In Vitro Disease Correction Using Retroviral Mediated Cdna Transfer, Lawrence Stramm, John Wolfe, Edward Schuchman, Mark Haskins, Donald Patterson, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Probing The Surface Forces Of Monolayer Films With An Atomic-Force Microscope, Nancy Burnham, Dawn Dominguez, Robert Mowery, Richard Colton

Nancy A. Burnham

Using an atomic force microscope (AFM), we have studied the attractive and adhesive forces between a cantilever tip and sample surfaces as a function of sample surface energy. The measured forces systematically increased with surface energy. The AFM is very sensitive; changes in the surface forces (i.e., attraction and adhesion) of monolayer covered samples could be clearly discerned when only the surface group of the monolayer film was changed from -CH3 to -CF3.

Thermodynamic Extent Of Counterion Release Upon Binding Oligolysines To Single-Stranded Nucleic Acids., David Mascotti, Timothy Lohman

David P. Mascotti

A major contribution to the binding free energy associated with most protein-nucleic acid complexes is the increase in entropy due to counterion release from the nucleic acid that results from electrostatic interactions. To examine this quantitatively, we have measured the thermodynamic extent of counterion release that results from the interaction between single-stranded homopolynucleotides and a series of oligolysines, possessing net charges z = 2-6, 8, and 10. This was accomplished by measuring the salt dependence of the intrinsic equilibrium binding constants--i.e., (delta log Kobs/delta log[K+])--over the range from 6 mM to 0.5 M potassium acetate. These data provide a rigorous …

New .Mu.2-S2--Coupled, Singly Bridged Double Cubane With The [(Fe4s4cl3)2s]4- Core. The Stepwise Synthesis And Structural Characterization Of (N-Bu4n)2(Ph4p)2[(Fe4s4cl3)2s], Paul Challen, Sang Koo, W. Dunham, D. Coucouvanis

Paul R. Challen

No abstract provided.

Electricity Price Shocks And International Trade, Peter Navarro

PETER NAVARRO

No abstract provided.

Segregation Distortion In Inheritance Of Progressive Rod Cone Degeneration (Prcd) In Miniature Poodle Dogs, Gregory M. Acland, Susan Halloran-Blanton, Joann A. Boughman, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

Infrared Spectroelectrochemical Measurements Of The Electrochemical Double Layer: Using Carbon Monoxide As A Double Layer Probe Molecule, Andrea Russell, Stanley Pons, Mark Anderson

Mark R. Anderson

The utility of infrared spectroelectrochemical measurements to provide information about the electrochemical interface has been previously demonstrated. The use of small adsorbate molecules as probes of the interface has only recently been investigated. The infrared spectroscopic behavior of adsorbed carbon monoxide in the presence of methanol, ethanol, n-propanol, isopropanol, and ethylene glycol as well as in alcohol/water binary solvent mixtures is presented. Changes in the Stark tuning rate for the adsorbed CO are correlated with solvent dipole reorganization in methanol, ethanol, and n-propanol. No change was observed for ethylene glycol or isopropanol. For the binary mixtures, a dramatic change in …

Regional Differences In Connexin32 And Connexin43 Messenger Rnas In Rat Brain, C. Naus, Daniel Belliveau, J. Bechberger

Daniel J. Belliveau

The regional distribution of gap junction mRNAs was examined in the adult rat brain. The level of connexin43 mRNA is more abundant than connexin32, being homogeneously distributed throughout different regions of brain. In contrast, there is dramatic heterogeneity in the level of connexin32 mRNA, with the highest level in the hindbrain. These results suggest that the gap junction genes are differentially expressed in regions of the adult rat brain.

Patterns Of Ionic Currents Around The Developing Oocyte Of The Cockroach, Blattella Germanica., Joseph Kunkel

Joseph Kunkel

The development of patterns of current around vitellogenic oocytes of the cockroach, Blattella germanica, was examined by means of a two-dimensional vibrating probe. Previtellogenic oocytes exhibited small unstable currents. Shortly after vitellogenic uptake began (oocytes 0.6-0.8 mm anterior to posterior) currents were either all inward or all outward at the plane of measuiement. A dorsoventral pattern of currents was first observed around oocytes a little larger than 0.8 mm. Current exited dorsally (source) and entered ventrally (sink). In these oocytes source and sink were small, less than half the anterior-posterior length. As oocytes grew, relative sizes of source and sink …

Microeconomic Principles In Action, James Whitney, Robert Moore

Jim Whitney

No abstract provided.

Metabolic Labeling Of Rod Outer Segment Phospholipids In Miniature Poodles With Progressive Rod-Cone Degeneration (Prcd), Mary Wetzel, Christian Fahlman, Paul O'Brien, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Frequency Of The Codon 807 Mutation In The Cgmp Phosphodiesterase Β-Subunit Gene In Irish Setters And Other Dog Breeds With Hereditary Retinal Degeneration, Gustavo D. Aguirre, V Baldwin, K M. Weeks, Gregory M. Acland, Kunal Ray

Gustavo D. Aguirre, VMD, PhD

Efficient Application Of The Schauder-Tychonoff Theorem To Systems Of Functional Differential Equations, William F. Trench

William F. Trench

No abstract provided.

The Justices Write Separately: Uses Of The Concurrence By The Rehnquist Court, Laura K. Ray

Laura K. Ray

No abstract provided.

A Note On A Toeplitz Inversion Formula, William F. Trench

William F. Trench

No abstract provided.