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Aerobic Exercise Alters Opioid Receptors Following Chronic Alcohol Exposure, James N. Brundage
Aerobic Exercise Alters Opioid Receptors Following Chronic Alcohol Exposure, James N. Brundage
Theses and Dissertations
Opioid receptors have been a target of pharmacological manipulation in alcohol use disorder (AUD) recovery protocols for many years. Aerobic exercise, a common adjunct in AUD recovery, is known to modulate opioid receptors (ORs) both during both acute and long term exposure. The three subtypes of ORs: mu (MOR), delta (DOR), and kappa (KOR) are all expressed on neurons in the mesocorticolimbic circuitry. Kappa-opioid receptors are expressed directly on dopamine (DA) neuron terminals in the nucleus accumbens (NAc). Mu and Delta ORs are expressed on cholinergic interneurons (CINs) and GABA neurons in the NAc. In alcohol dependent rodents, KORs are …
Do Shape And Volume Of Subcortical Neural Structures Involved In Reward Processing Correlate With Body Mass And Food Reward In Adolescent Females?, Kelsey K. Zaugg
Do Shape And Volume Of Subcortical Neural Structures Involved In Reward Processing Correlate With Body Mass And Food Reward In Adolescent Females?, Kelsey K. Zaugg
Theses and Dissertations
Background: The prevalence of adolescent obesity has increased drastically in the last few decades, spurring research examining causes and consequences of this chronic health condition. Neuroimaging techniques are being used to determine possible neural correlates of obesity that could help inform research in this field. However, the research among adolescents is not as abundant and findings so far are contradictory. This study sought to examine the association of the shape and volume of subcortical brain structures involved in reward processing with weight status in adolescent females. Additionally, this study sought to determine if the shape and volume of these structures …
Peripheral Dopamine 2 Receptors Both Modulate Central Dopamine Release And Adopt In A Similar Manner To That Of Central Dopamine 2 Receptors, J. Daniel Obray
Peripheral Dopamine 2 Receptors Both Modulate Central Dopamine Release And Adopt In A Similar Manner To That Of Central Dopamine 2 Receptors, J. Daniel Obray
Theses and Dissertations
Alcohol use disorder is a debilitating disorder affecting nearly 5% of people in the United States. Despite the prevalence of alcohol use disorder few affected individuals seek treatment and of those who do many will relapse. This highlights a need to develop new treatments for alcohol use disorder that are both more accessible and more effective. This dissertation characterizes a novel pathway involved in ethanol enhancement of dopamine levels in the nucleus accumbens as well as investigating alterations in dopamine 2 receptor expression and function following an acute dose of ethanol. This was done by using microdialysis to measure dopamine …