Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
The Physiological Effects Of Resistant Starch On Obesity And Diabetes, Felicia Robin Goldsmith
The Physiological Effects Of Resistant Starch On Obesity And Diabetes, Felicia Robin Goldsmith
LSU Doctoral Dissertations
Three studies were performed to determine the effects of RS on body weight and adiposity in HF DIO, diabetic C57BL/6J and GLP-1 receptor KO mice as well as genetically obese ZDF rats. The first study was a dose-response experiment for HM260 (0, 15, or 28 g/100 g diet) against the anti-diabetes drug SG (Januvia®) (0 or 0.4 g/100 g diet) in HF DIO C57BL/6J (n=55) mice injected with STZ in order to assess synergy. The most effective combination was used in the second study, the purpose of which was to determine the mechanistic importance of GLP-1 in GLP-1R KO (n=25) …
The Role Of Ad-36 And Its E4orf-1 Protein In Modulating Glycemic Control, Emily Jane Dhurandhar
The Role Of Ad-36 And Its E4orf-1 Protein In Modulating Glycemic Control, Emily Jane Dhurandhar
LSU Doctoral Dissertations
Current treatment strategies for Type 2 Diabetes Mellitus (T2DM) include a range of anti-diabetic drugs, supplemented by lifestyle modifications to reduce dietary fat intake and body fat. However, for their anti-diabetic action, most drugs recruit insulin signaling pathways, which are already impaired in T2DM. Also, compliance and success in achieving sustained improvements in diet or obesity over the long term is marginal. Therefore, an agent that improves diabetes independent of insulin signaling or lifestyle changes may be highly useful. Human adenovirus Ad36 offers such a model. Ad36 improves glycemic control in chow-fed mice or rats and attenuates diabetes and hepatic …