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Onset Of Major Depressive Disorder Among Adolescents, John P. Hoffmann, Scott A. Baldwin, Felicia G. Cerbone

Faculty Publications

Objectives: To examine the association between parental affective disorders and psychoactive substance use disor- ders and the onset of major depressive disorder (MDD) among adolescents and young adults and to determine whether this association is affected by stressful life events, family cohesion, self-esteem, or gender. Method: Prospective cohort study of 804 adolescents, aged 11–17 years, and their parents who were followed for seven consecutive years. The sam- ple was drawn from the Minneapolis-St. Paul metropolitan area. Parental diagnoses were based on Structured Clinical Interview for DSM-III-R administered during study screening stage. Diagnoses of MDD and age of onset were based …