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Escalation Of I.V. Cocaine Self- Administration And Reinstatement Of Cocaine-Seeking Behavior In Rats Bred For High And Low Saccharin Intake., J. Perry, A. D. Morgan, J. J. Anker, Nancy K. Dess, M. E. Carroll
Escalation Of I.V. Cocaine Self- Administration And Reinstatement Of Cocaine-Seeking Behavior In Rats Bred For High And Low Saccharin Intake., J. Perry, A. D. Morgan, J. J. Anker, Nancy K. Dess, M. E. Carroll
Nancy K Dess
RATIONALE: Rats selectively bred for high saccharin (HiS) intake consume more alcohol, acquire intravenous (i.v.) cocaine self-administration more rapidly, and show more dysregulated patterns of cocaine self-administration than their low saccharin-consuming (LoS) counterparts. OBJECTIVES: The purpose of the present study was to determine whether HiS and LoS rats also differ in the escalation, maintenance, extinction, and reinstatement of i.v. cocaine self-administration. MATERIALS AND METHODS: Two experiments were conducted in separate groups of rats. In the first experiment, HiS and LoS female rats were allowed to self-administer cocaine [0.4 mg/kg; fixed ratio (FR) 1] under short (ShA, 2 h per day) …