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Investigation Of The Interaction Of D-Amphetamine And Amantadine Hydrochloride Using Repeated Acquisitions With Serial Reversal Discriminations, Elizabeth Dozier Jones
Investigation Of The Interaction Of D-Amphetamine And Amantadine Hydrochloride Using Repeated Acquisitions With Serial Reversal Discriminations, Elizabeth Dozier Jones
Doctoral Dissertations
The purpose of this series of studies was to investigate the interaction of d-amphetamine and amantadine hydrochloride employing serial discrimination reversals with repeated acquisitions. Specifically, the blockade of the effects of d-amphetamine by amantadine hydrochloride was investigated.
In meeting this goal, dose-response curves were determined independently for d-amphetamine and amantadine hydrochloride. The dose-response curve for d-amphetamine indicated that the 0.5 mg/kg dosage provided for optimal discrimination of SDR, while dosages of 1.0 mg/kg and 2.0 mg/kg proved to be disruptive. The experiments investigating amantadine hydrochloride indicated that dosages above 10 mg/kg were detrimental to the discrimination task, while dosages below …