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Remote Preconditioning: Evaluating The Efficacy Of Cardioprotection In Type-2 Diabetes And Exploring The Mechanistic Role Of Exosomes, Joseph Michael Wider
Remote Preconditioning: Evaluating The Efficacy Of Cardioprotection In Type-2 Diabetes And Exploring The Mechanistic Role Of Exosomes, Joseph Michael Wider
Wayne State University Dissertations
Remote preconditioning is a promising and robust treatment for myocardial
ischemia/reperfusion injury that evokes cardioprotection through endogenous neural
and/or humoral signaling. A recent study has reported that protective signaling is
mediated by exosomes through the circulation; however this concept is supported by
limited and inconsistent evidence. Despite overwhelming success in preclinical studies,
the efficacy of remote preconditioning in human studies is inconclusive. Importantly, the
majority of remote preconditioning studies use healthy animal models despite growing
evidence that comorbidities, such as type-2 diabetes, may negatively influence
outcomes. Nonetheless, the efficacy of remote preconditioning in the setting of type-2
diabetes has not …
Human Kinome In Skeletal Muscle Insulin Resistance, Yue Qi
Human Kinome In Skeletal Muscle Insulin Resistance, Yue Qi
Wayne State University Dissertations
Protein kinases play fundamental roles in regulation of biological processes and functions, such as insulin signaling and glucose metabolism. Dysregulation of protein kinases may cause impaired cell signaling and human diseases, such as metabolic syndrome and type 2 diabetes (T2D). Skeletal muscle is the main site responsible for insulin-stimulated glucose disposal, and insulin resistance in skeletal muscle is one of the key features of the pathogenesis of T2D. Therefore, malfunction of protein kinases and their interaction proteins may contribute to the molecular mechanism of insulin resistance in human skeletal muscle. However, no large scale profiling study has been reported to …