Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- AER (1)
- Anisotropy (1)
- COL11A1 (1)
- Calpain (1)
- Chicken (1)
-
- Craniofacial defects (1)
- Cytoskeleton (1)
- DiI (1)
- Directional outgrowth (1)
- EGTA (1)
- Fgf (1)
- Fluorescence (1)
- Gelsolin (1)
- Genetic construct (1)
- HtrA-1 (1)
- Human (1)
- Ionomycin (1)
- Limb mesenchyme (1)
- Membrane fluidity (1)
- Mice (1)
- Mmp-13 (1)
- Mouse (1)
- Murine (1)
- Nucleated cells (1)
- Ophthalmic (1)
- Osteoarthritis (1)
- Patman (1)
- Pax3 (1)
- Phosphatidylserine (1)
- Placode (1)
Articles 1 - 5 of 5
Full-Text Articles in Entire DC Network
The Effects Of Inhibiting Wnt Secretion And Activity On Cranial And Neural Development, Julie Louise Hulet
The Effects Of Inhibiting Wnt Secretion And Activity On Cranial And Neural Development, Julie Louise Hulet
Theses and Dissertations
Wnt signaling has been shown to have several roles in the development of sensory neurons, particularly in the ophthalmic portion of the trigeminal nerve. Many of these studies have relied on the conclusion that Wnt is necessary but not sufficient for the induction and maintenance of the neural precursor cells that develop in the ophthalmic placode. Wnt had been inhibited in the ophthalmic placode using a dominant negative t-cell factor (TCF) and resulted in the loss of Pax3 expression (indicative of undifferentiated placode cells) in all targeted cells, suggesting a loss of specification/commitment of these cells to the sensory neuron …
Expression Of Osteoarthritis Biomarkers In Temporomandibular Joints Of Mice With And Without Receptor For Advanced Glycation End Products (Rage), Elizabeth Murayama Chavez Matias
Expression Of Osteoarthritis Biomarkers In Temporomandibular Joints Of Mice With And Without Receptor For Advanced Glycation End Products (Rage), Elizabeth Murayama Chavez Matias
Theses and Dissertations
This thesis will be organized into three chapters discussing the mechanism underlying the onset and progression of osteoarthritis (OA) in the temporomandibular joint (TMJ). Understanding the mechanism of OA development in the TMJ helps in understanding how OA progresses and how to treat this disease. The goal of this investigation is to examine the process of cartilage degeneration and OA biomarker expression in the TMJ to understand their role in TMJ OA onset and development.Chapter one covers mechanisms that are altered in TMJ OA during disease progression. Using animal models with different stressors such as mechanical disturbances, direct injury, and …
Membrane Properties Involved In Calcium-Stimulated Microparticle Release From The Plasma Membranes Of S49 Lymphoma Cells, Lauryl Elizabeth Campbell
Membrane Properties Involved In Calcium-Stimulated Microparticle Release From The Plasma Membranes Of S49 Lymphoma Cells, Lauryl Elizabeth Campbell
Theses and Dissertations
The mechanism of microparticle shedding from the plasma membrane of calcium-loaded cells has been investigated in erythrocytes and platelets. Recent studies have revealed the physiological and clinical importance of microparticle release from nucleated cells such as lymphocytes and endothelium. The experiments of this study were designed to address whether simple mechanisms discovered in platelets and erythrocytes also apply to the more complex nucleated cells. Four such mechanisms were addressed: potassium efflux, transbilayer phosphatidylserine migration, cytoskeleton degradation, and membrane lipid order. The rate and amount of microparticle release in the presence of a calcium ionophore, ionomycin, was assayed by light scatter …
Role Of Wnt5a And Possible Pathway Of Action Through Ror2 In Proximodistal Outgrowth Of The Limb, Tiffanie M. Dahl
Role Of Wnt5a And Possible Pathway Of Action Through Ror2 In Proximodistal Outgrowth Of The Limb, Tiffanie M. Dahl
Theses and Dissertations
Despite over 60 years of study, the molecular pathways and mechanisms governing limb outgrowth and patterning remain poorly understood. Fgfs expressed in the AER are known to be necessary and sufficient for proximodistal limb outgrowth and have been proposed to have a chemoattractive role. Wnt5a is a secreted factor which is expressed in a gradient in the distal limb with the highest concentration next to the AER. The presence of the AER is necessary to establish this gradient. Expression of Wnt5a in a concentration dependant manner can be induced in the limb through the implantation of a bead soaked in …
Construction Of A Col11a1 Transgene Vector, Cameron Mckell Beck
Construction Of A Col11a1 Transgene Vector, Cameron Mckell Beck
Theses and Dissertations
Background: Cartilage disorders affect millions of people in the United States alone, with effects ranging from poor skeletal development and joint pain to shortened lifespan and perinatal lethality. Many of these disorders have their root in defects of collagen, type XI collagen being among the most important. A mouse model of such a type XI collagen defect is the chondrodysplasia (cho) mutant. Mice homozygous for this null mutation in the Col11a1 gene do not express the α1 chain of type XI collagen. This results in a functional knockout of type XI collagen, leading to insufficient skeletal development and perinatal lethality. …