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Covid-19 And Preparing Planetary Health For Future Ecological Crises: Hopes From Glycomics For Vaccine Innovation, Xueqing Wang, Zhaohua Zhong, Wei Wang
Covid-19 And Preparing Planetary Health For Future Ecological Crises: Hopes From Glycomics For Vaccine Innovation, Xueqing Wang, Zhaohua Zhong, Wei Wang
Research outputs 2014 to 2021
A key lesson emerging from COVID-19 is that pandemic proofing planetary health against future ecological crises calls for systems science and preventive medicine innovations. With greater proximity of the human and animal natural habitats in the 21st century, it is also noteworthy that zoonotic infections such as COVID-19 that jump from animals to humans are increasingly plausible in the coming decades. In this context, glycomics technologies and the third alphabet of life, the sugar code, offer veritable prospects to move omics systems science from discovery to diverse applications of relevance to global public health and preventive medicine. In this expert …
Gut Microbiota Interplay With Covid-19 Reveals Links To Host Lipid Metabolism Among Middle Eastern Populations, Mohammad Tahseen Al Bataineh, Andreas Henschel, Mira Mousa, Marianne Daou, Fathimathuz Waasia, Hussein Kannout, Mariam Khalili, Mohd Azzam Kayasseh, Abdulmajeed Alkhajeh, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Samuel F. Feng, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership
Gut Microbiota Interplay With Covid-19 Reveals Links To Host Lipid Metabolism Among Middle Eastern Populations, Mohammad Tahseen Al Bataineh, Andreas Henschel, Mira Mousa, Marianne Daou, Fathimathuz Waasia, Hussein Kannout, Mariam Khalili, Mohd Azzam Kayasseh, Abdulmajeed Alkhajeh, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Samuel F. Feng, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership
Research outputs 2014 to 2021
The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10–6) and Bacteroides (p-value = 5.67 × 10–8). We also revealed a higher relative abundance of the highly …
A Blockchain-Based Authentication Protocol For Cooperative Vehicular Ad Hoc Network, A. F. M. S. Akhter, Mohiuddin Ahmed, A. F. M. S. Shah, Adnan Anwar, A. S. M. Kayes, Ahmet Zengin
A Blockchain-Based Authentication Protocol For Cooperative Vehicular Ad Hoc Network, A. F. M. S. Akhter, Mohiuddin Ahmed, A. F. M. S. Shah, Adnan Anwar, A. S. M. Kayes, Ahmet Zengin
Research outputs 2014 to 2021
The efficiency of cooperative communication protocols to increase the reliability and range of transmission for Vehicular Ad hoc Network (VANET) is proven, but identity verification and communication security are required to be ensured. Though it is difficult to maintain strong network connections between vehicles because of there high mobility, with the help of cooperative communication, it is possible to increase the communication efficiency, minimise delay, packet loss, and Packet Dropping Rate (PDR). However, cooperating with unknown or unauthorized vehicles could result in information theft, privacy leakage, vulnerable to different security attacks, etc. In this paper, a blockchain based secure and …
Recovery Agenda For Sustainable Development Post Covid-19 At The Country Level: Developing A Fuzzy Action Priority Surface, Meisam Ranjbari, Zahra S. Esfandabadi, Simone D. Scagnelli, Peer O. Siebers, Francesco Quatraro
Recovery Agenda For Sustainable Development Post Covid-19 At The Country Level: Developing A Fuzzy Action Priority Surface, Meisam Ranjbari, Zahra S. Esfandabadi, Simone D. Scagnelli, Peer O. Siebers, Francesco Quatraro
Research outputs 2014 to 2021
As a response to the urgent call for recovery actions against the COVID-19 crisis, this research aims to identify action priority areas post COVID-19 toward achieving the targets of the sustainable development goals (SDGs) within the 2030 Agenda for Sustainable Development launched by the United Nations (UN). This paper applies a mixed-method approach to map the post-COVID-19 SDGs targets on a fuzzy action priority surface at the country level in Iran, as a developing country, by taking the following four main steps: (1) using a modified Delphi method to make a list of the SDGs targets influenced by COVID-19; (2) …
Kynurenic Acid May Underlie Sex-Specific Immune Responses To Covid-19, Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, Nicholas J. W. Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J. Moore, M. Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I. Ko, Sajid A. Khan, Akiko Iwasaki, Caroline H. Johnson, Yale Impact Research Team
Kynurenic Acid May Underlie Sex-Specific Immune Responses To Covid-19, Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, Nicholas J. W. Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J. Moore, M. Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I. Ko, Sajid A. Khan, Akiko Iwasaki, Caroline H. Johnson, Yale Impact Research Team
Research outputs 2014 to 2021
Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences. Because immune responses are, in part, regulated by metabolites, we examined the serum metabolomes of COVID-19 patients. In male patients, kynurenic acid (KA) and a high KA–to–kynurenine (K) ratio (KA:K) positively correlated with age and with inflammatory cytokines and chemokines and negatively correlated with T cell responses. Males that clinically deteriorated had a higher KA:K than those that stabilized. KA inhibits glutamate release, and glutamate abundance was lower in patients that clinically deteriorated and correlated with immune responses. Analysis of …
Association Between Community-Based Self-Reported Covid-19 Symptoms And Social Deprivation Explored Using Symptom Tracker Apps: A Repeated Cross-Sectional Study In Northern Ireland, Jennifer M. Mckinley, David Cutting, Neil Anderson, Conor Graham, Brian Johnston, Ute Mueller, Peter M. Atkinson, Hugo Van Woerden, Declan T. Bradley, Frank Kee
Association Between Community-Based Self-Reported Covid-19 Symptoms And Social Deprivation Explored Using Symptom Tracker Apps: A Repeated Cross-Sectional Study In Northern Ireland, Jennifer M. Mckinley, David Cutting, Neil Anderson, Conor Graham, Brian Johnston, Ute Mueller, Peter M. Atkinson, Hugo Van Woerden, Declan T. Bradley, Frank Kee
Research outputs 2014 to 2021
Objectives: The aim of the study was to investigate the spatial and temporal relationships between the prevalence of COVID-19 symptoms in the community-level and area-level social deprivation. Design: Spatial mapping, generalised linear models, using time as a factor and spatial-lag models were used to explore the relationship between self-reported COVID-19 symptom prevalence as recorded through two smartphone symptom tracker apps and a range of socioeconomic factors using a repeated cross-sectional study design. Setting: In the community in Northern Ireland, UK. The analysis period included the earliest stages of non-pharmaceutical interventions and societal restrictions or 'lockdown' in 2020. Participants: Users of …
A Novel Augmented Deep Transfer Learning For Classification Of Covid-19 And Other Thoracic Diseases From X-Rays, Fouzia Atlaf, Syed M. S. Islam, Naeem K. Janjua
A Novel Augmented Deep Transfer Learning For Classification Of Covid-19 And Other Thoracic Diseases From X-Rays, Fouzia Atlaf, Syed M. S. Islam, Naeem K. Janjua
Research outputs 2014 to 2021
Deep learning has provided numerous breakthroughs in natural imaging tasks. However, its successful application to medical images is severely handicapped with the limited amount of annotated training data. Transfer learning is commonly adopted for the medical imaging tasks. However, a large covariant shift between the source domain of natural images and target domain of medical images results in poor transfer learning. Moreover, scarcity of annotated data for the medical imaging tasks causes further problems for effective transfer learning. To address these problems, we develop an augmented ensemble transfer learning technique that leads to significant performance gain over the conventional transfer …
Nested Ecology And Emergence In Pandemics, Aaron Jenkins, Stacy D. Jupiter, Anthony Capon, Pierre Horwitz, Joel Negin
Nested Ecology And Emergence In Pandemics, Aaron Jenkins, Stacy D. Jupiter, Anthony Capon, Pierre Horwitz, Joel Negin
Research outputs 2014 to 2021
No abstract provided.