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Articles 1 - 5 of 5
Full-Text Articles in Entire DC Network
Data In Support Of Ubsrd: The Ubiquitin Structural Relational Database, Joseph S. Harrison, Tim M. Jacobs, Kevin Houlihan, Koenraad Van Doorslaer, Brian Kuhlman
Data In Support Of Ubsrd: The Ubiquitin Structural Relational Database, Joseph S. Harrison, Tim M. Jacobs, Kevin Houlihan, Koenraad Van Doorslaer, Brian Kuhlman
College of the Pacific Faculty Articles
This article provides information to support the database article titled "UbSRD: The Ubiquitin Structural Relational Database" (Harrison et al., 2015) [1] . The ubiquitin-like homology fold (UBL) represents a large family that encompasses both post-translational modifications, like ubiquitin (UBQ) and SUMO, and functional domains on many biologically important proteins like Parkin, UHRF1 (ubiquitin-like with PDB and RING finger domains-1), and Usp7 (ubiquitin-specific protease-7) (Zhang et al., 2015; Rothbart et al., 2013; Burroughs et al., 2012; Wauer et al., 2015) [2], [3], [4], [5]. The UBL domain can participate in several unique protein-protein interactions (PPI) since protein adducts can be attached …
Sexually Dimorphic Gene Expression In The Lateral Eyes Of Euphilomedes Carcharodonta (Ostracoda, Pancrustacea), Andrea Sajuthi, Brenna Carrillo-Zazueta, Briana Hu, Anita Wang, Logan Brodnansky, John Mayberry, Ajna S. Rivera
Sexually Dimorphic Gene Expression In The Lateral Eyes Of Euphilomedes Carcharodonta (Ostracoda, Pancrustacea), Andrea Sajuthi, Brenna Carrillo-Zazueta, Briana Hu, Anita Wang, Logan Brodnansky, John Mayberry, Ajna S. Rivera
College of the Pacific Faculty Articles
Background: The evolution and development of sexual dimorphism illuminates a central question in biology: How do similar genomes produce different phenotypes? In an XX/XO system especially the state of a sexually dimorphic trait is determined by differences in gene expression, as there are no additional genetic loci in either sex. Here, we examine the XX/XO ostracod crustacean species Euphilomedes carcharodonta. This species exhibits radical sexual dimorphism of their lateral eyes, females have only a tiny simple lateral eye while males have elaborate ommatidial eyes. Results: We find that males express three of nine eye-development gene homologs at significantly higher levels …
Efficient Photochemical Synthesis Of Peptide-Α-Phenylthioesters, Andrew Pardo, Tyrone J. Hogenauer, Zhefeng Cai, Julian A. Vellucci, Efrain M. Castillo, Carl W. Dirk, Andreas H. Franz, Katja Michael
Efficient Photochemical Synthesis Of Peptide-Α-Phenylthioesters, Andrew Pardo, Tyrone J. Hogenauer, Zhefeng Cai, Julian A. Vellucci, Efrain M. Castillo, Carl W. Dirk, Andreas H. Franz, Katja Michael
College of the Pacific Faculty Articles
Low yields and substantial epimerization of peptide-α-thioesters often compromise the overall efficiency of native chemical ligation (NCL). Peptide arylthioesters are more reactive than peptide alkylthioesters in NCL, but are also more difficult to handle due to their propensity to hydrolyze, and are therefore often generated in situ. However, pre-prepared peptide arylthioesters are required for some NCL applications. Here we present a 7-nitroindoline-based photochemical method that generates protected peptide phenylthioesters under neutral reaction conditions via their activated esters from photoreactive peptide precursors in high isolated yields, and with low levels of epimerization. This method is fully compatible with Fmoc-strategy solid-phase peptide …
An Allosteric Interaction Links Usp7 To Deubiquitination And Chromatin Targeting Of Uhrf1, Zhi-Min Zhang, Scott B. Rothbart, David F. Allison, Qian Cai, Joseph S. Harrison, Lin Li, Yinsheng Wang, Brian D. Strahl, Gang Greg Wang, Jikui Song
An Allosteric Interaction Links Usp7 To Deubiquitination And Chromatin Targeting Of Uhrf1, Zhi-Min Zhang, Scott B. Rothbart, David F. Allison, Qian Cai, Joseph S. Harrison, Lin Li, Yinsheng Wang, Brian D. Strahl, Gang Greg Wang, Jikui Song
College of the Pacific Faculty Articles
The protein stability and chromatin functions of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) are regulated in a cell-cycle-dependent manner. We report a structural characterization of the complex between UHRF1 and the deubiquitinase USP7. The first two UBL domains of USP7 bind to the polybasic region (PBR) of UHRF1, and this interaction is required for the USP7-mediated deubiquitination of UHRF1. Importantly, we find that the USP7-binding site of the UHRF1 PBR overlaps with the region engaging in an intramolecular interaction with the N-terminal tandem Tudor domain (TTD). We show that the USP7-UHRF1 interaction perturbs the TTD-PBR interaction of …
Acylation Of Trans-2-Substituted Cyclohexanols: The Impact Of Substituent Variation On The Pyridine-Induced Reversal Of Diastereoselectivity, Sven Hackbusch, Andreas H. Franz
Acylation Of Trans-2-Substituted Cyclohexanols: The Impact Of Substituent Variation On The Pyridine-Induced Reversal Of Diastereoselectivity, Sven Hackbusch, Andreas H. Franz
College of the Pacific Faculty Articles
Numerous methods for the stereoselective synthesis of chiral compounds exist in the literature, which use chiral templates or catalysts. Only in a limited number of cases have achiral catalysts been shown to significantly influence the stereochemical outcomes of reactions. Previous studies in our laboratories have revealed the achiral acyl-transfer catalyst pyridine to alter the stereochemical outcome of the reaction of racemic trans-2-substituted cyclohexanols with racemic 2-chloropropionyl chloride and cause a reversal of diastereoselectivity. The current paper presents the application of the reaction scheme to a wider number of substrates and reveals the importance of the heteroatom in the trans-2-substituent