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Sars-Cov-2 Main Protease Targeting Potent Fluorescent Inhibitors: Repurposing Thioxanthones, Gönül Saadet Batibay, Eyüp Meti̇n
Sars-Cov-2 Main Protease Targeting Potent Fluorescent Inhibitors: Repurposing Thioxanthones, Gönül Saadet Batibay, Eyüp Meti̇n
Turkish Journal of Chemistry
The coronavirus disease, COVID-19, is the major focus of the whole world due to insufficient treatment options. It has spread all around the world and is responsible for the death of numerous human beings. The future consequences for the disease survivors are still unknown. Hence, all contributions to understand the disease and effectively inhibit the effects of the disease have great importance. In this study, different thioxanthone based molecules, which are known to be fluorescent compounds, were selectively chosen to study if they can inhibit the main protease of SARS-CoV-2 using various computational tools. All candidate ligands were optimized, molecular …
A Type-2 Fuzzy Rule-Based Model For Diagnosis Of Covid-19, İhsan Şahi̇n, Erhan Akdoğan, Mehmet Emi̇n Aktan
A Type-2 Fuzzy Rule-Based Model For Diagnosis Of Covid-19, İhsan Şahi̇n, Erhan Akdoğan, Mehmet Emi̇n Aktan
Turkish Journal of Electrical Engineering and Computer Sciences
In this study, a type-2 fuzzy logic-based decision support system comprising clinical examination and blood test results that health professionals can use in addition to existing methods in the diagnosis of COVID-19 has been developed. The developed system consists of three fuzzy units. The first fuzzy unit produces COVID-19 positivity as a percentage according to the respiratory rate, loss of smell, and body temperature values, and the second fuzzy unit according to the C-reactive protein, lymphocyte, and D-dimer values obtained as a result of the blood tests. In the third fuzzy unit, the COVID-19 positivity risks according to the clinical …
Developing A Fake News Identification Model With Advanced Deep Languagetransformers For Turkish Covid-19 Misinformation Data, Mehmet Bozuyla, Akin Özçi̇ft
Developing A Fake News Identification Model With Advanced Deep Languagetransformers For Turkish Covid-19 Misinformation Data, Mehmet Bozuyla, Akin Özçi̇ft
Turkish Journal of Electrical Engineering and Computer Sciences
The massive use of social media causes rapid information dissemination that amplifies harmful messages such as fake news. Fake-news is misleading information presented as factual news that is generally used to manipulate public opinion. In particular, fake news related to COVID-19 is defined as 'infodemic' by World Health Organization. An infodemic is a misleading information that causes confusion which may harm health. There is a high volume of misinformation about COVID-19 that causes panic and high stress. Therefore, the importance of development of COVID-19 related fake news identification model is clear and it is particularly important for Turkish language from …
A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha
A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha
Turkish Journal of Chemistry
Since the coronavirus disease has been declared a global pandemic, it had posed a challenge among researchers and raised common awareness and collaborative efforts towards finding the solution. Caused by severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2), coronavirus drug design strategy needs to be optimized. It is understandable that cognizance of the pathobiology of COVID-19 can help scientists in the development and discovery of therapeutically effective antiviral drugs by elucidating the unknown viral pathways and structures. Considering the role of artificial intelligence and machine learning with its advancements in the field of science, it is rational to use these methods which …
Synthesis, Characterization, Computational Analyses, In Silico Admet Studies, And Inhibitory Action Against Sars-Cov-2 Main Protease (Mpro) Of A Schiff Base, Songül Şahi̇n, Necmi̇ Dege
Synthesis, Characterization, Computational Analyses, In Silico Admet Studies, And Inhibitory Action Against Sars-Cov-2 Main Protease (Mpro) Of A Schiff Base, Songül Şahi̇n, Necmi̇ Dege
Turkish Journal of Chemistry
COVID-19 disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) has struck the whole world and raised severe health, economic, and social problems. Many scientists struggled to find a vaccine or an antiviral drug. Eventually, both vaccines and recommended drugs, repurposed drugs, or drug combinations were found, but new strains of SARS-CoV-2 continue to threaten human life and health. As part of the fight against COVID-19 disease, this study involves an in silico molecular docking analysis on the main protease (Mpro) of SARS-CoV-2. To this aim, a Schiff base compound was synthesized and characterized using spectroscopic techniques, including X-ray, …
Effects Of Covid-19 On Electric Energy Consumption In Turkey And Ann-Basedshort-Term Forecasting, Harun Özbay, Adem Dalcali
Effects Of Covid-19 On Electric Energy Consumption In Turkey And Ann-Basedshort-Term Forecasting, Harun Özbay, Adem Dalcali
Turkish Journal of Electrical Engineering and Computer Sciences
: Due to the coronavirus, millions of people worldwide carry out their work, education, shopping, culture, and entertainment activities from their homes now using the advantages of today's technology. Apart from this, patient care and follow-up are carried out with the help of electronic equipment especially in the institutions where health services are provided. It is important to provide a reliable electricity supply for humanity so that people can perform all these services. In this study, the outlook of energy in Turkey was examined. The current energy consumption and investments were examined. Then, the precautions by the government in the …
Soft $\Beta$-Rough Sets And Their Application To Determine Covid-19, Mostafa K. El Bably, Abd El Fattah A. El Atik
Soft $\Beta$-Rough Sets And Their Application To Determine Covid-19, Mostafa K. El Bably, Abd El Fattah A. El Atik
Turkish Journal of Mathematics
Soft rough set theory has been presented as a basic mathematical model for decision-making for many real-life data. However, soft rough sets are based on a possible fusion of rough sets and soft sets which were proposed by Feng et al. [20]. The main contribution of the present article is to introduce a modification and a generalization for Feng's approximations, namely, soft $\beta$-rough approximations, and some of their properties will be studied. A comparison between the suggested approximations and the previous one [20] will be discussed. Some examples are prepared to display the validness of these proposals. Finally, we put …
Comparison Of Clinically Approved Molecules On Sars-Cov-2 Drug Target Proteins: A Molecular Docking Study, Hasan Çubuk, Mehmet Özbi̇l
Comparison Of Clinically Approved Molecules On Sars-Cov-2 Drug Target Proteins: A Molecular Docking Study, Hasan Çubuk, Mehmet Özbi̇l
Turkish Journal of Chemistry
The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. Most of these studies target the receptor-binding domain of spike protein of SARS-CoV-2, which is known to bind to the human ACE2 receptor and SARS-CoV-2 main protease, vital for the virus' replication. However, there might be a third target, human furin protease, which cleaves the virus' S1-S2 domains playing an active role in its entry into the host cell. In this study, we docked …
Synthesis And Molecular Docking Study Of Novel Covid-19 Inhibitors, Zuhal Gerçek, Deni̇z Ceyhan, Erol Erçağ
Synthesis And Molecular Docking Study Of Novel Covid-19 Inhibitors, Zuhal Gerçek, Deni̇z Ceyhan, Erol Erçağ
Turkish Journal of Chemistry
In 2020, the world tried to combat the corona virus (COVID-19) pandemic. A proven treatment method specific to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is still not found. In this study, seven new antiviral compounds were designed for COVID-19 treatment. The ability of these compounds to inhibit COVID-19's RNA processing was calculated by the molecular docking study. It has been observed that the compounds can have high binding affinities especially against NSP12 (between -9.06 and -8.00 kcal/mol). The molecular dynamics simulation of NSP12-ZG 7 complex proved the stability of interaction. The synthesis of two most active molecules was performed by …
A Transfer Learning-Based Deep Learning Approach For Automated Covid-19diagnosis With Audio Data, Devri̇m Akgün, Abdullah Talha Kabakuş, Zehra Karapinar Şentürk, Arafat Şentürk, Enver Küçükkülahli
A Transfer Learning-Based Deep Learning Approach For Automated Covid-19diagnosis With Audio Data, Devri̇m Akgün, Abdullah Talha Kabakuş, Zehra Karapinar Şentürk, Arafat Şentürk, Enver Küçükkülahli
Turkish Journal of Electrical Engineering and Computer Sciences
The COVID-19 pandemic has caused millions of deaths and changed daily life globally. Countries have declared a half or full lockdown to prevent the spread of COVID-19. According to medical doctors, as many people as possible should be tested to identify their status, and corresponding actions then should be taken for COVID-19 positive cases. Despite the clear necessity of these medical tests, many countries are still struggling to acquire them. This fact clearly indicates the necessity of a large-scale, cheap, fast, and accurate alternative prescreening tool that can be used for the diagnosis of COVID-19 while waiting for the medical …
Subjective Analysis Of Social Distance Monitoring Using Yolo V3 Architecture Andcrowd Tracking System, Muhammed Murat Özbek, Mustafa Syed, İlkay Öksüz
Subjective Analysis Of Social Distance Monitoring Using Yolo V3 Architecture Andcrowd Tracking System, Muhammed Murat Özbek, Mustafa Syed, İlkay Öksüz
Turkish Journal of Electrical Engineering and Computer Sciences
The lethal infection, World Health Organization (WHO) reported coronavirus (COVID-19) as a pandemic.Lack of proper vaccine, low levels of immunity against COVID-19 has led to vulnerability of the human beings. Due tolack of efficient vaccine treatment, the only options left to fight against this pandemic are lockdown and social distance.This work offers an autonomous monitoring system on social distancing using deep learning techniques. The proposedarchitecture tracks the humans on roads and calculates their distance between each other. This surveillance detects thefurore violation of social distance utilizing CCTV cameras. The proposed framework uses YOLO v3 object-detectionmodel built on COCO dataset and …
A Fuzzy Expert System For Predicting The Mortality Of Covid'19, Monika Mangla, Nonita Sharma, Poonam Mittal
A Fuzzy Expert System For Predicting The Mortality Of Covid'19, Monika Mangla, Nonita Sharma, Poonam Mittal
Turkish Journal of Electrical Engineering and Computer Sciences
The COVID-19 pandemic has had a widespread impact on health and economy across the globe. It is leading to a huge number of deaths per day. Few researchers have been attracted to analyzing the mortality rate of COVID-19 from various perspectives. During the research, it has become evident that these fatalities are not only caused by COVID19, but they are also affected by some other factors. The authors of this paper aim to encompass three important types of factors viz. risk factors, clinical factors, and miscellaneous factors that influence the mortality of COVID-19. This manuscript presents a rule-based model under …
Towards An Ontology-Based Approach To The "New Normality" After Covid-19:The Spanish Case During Pandemic First Wave, Evelio Gonzalez
Towards An Ontology-Based Approach To The "New Normality" After Covid-19:The Spanish Case During Pandemic First Wave, Evelio Gonzalez
Turkish Journal of Electrical Engineering and Computer Sciences
The impact of the pandemic caused by COVID-19 has been immense in all fields of human activity. In most of the affected countries, the authorities have decreed a series of legal measures to try to stop the growth of the disease and the number of people affected by it. These legal measures involved, in most cases, restrictions on the free movement of people and on work and trade activities, new hygiene procedures, and social distancing. In the particular case of Spain, the rapid evolution of the pandemic led to the declaration of a so-called state of alarm and a period …
A Deep Transfer Learning Based Model For Automatic Detection Of Covid-19from Chest X-Rays, Prateek Chhikara, Prakhar Gupta, Prabhjot Singh, Tarunpreet Bhatia
A Deep Transfer Learning Based Model For Automatic Detection Of Covid-19from Chest X-Rays, Prateek Chhikara, Prakhar Gupta, Prabhjot Singh, Tarunpreet Bhatia
Turkish Journal of Electrical Engineering and Computer Sciences
Deep learning in medical imaging has revolutionized the way we interpret medical data, as high computational devices' capabilities are far more than their creators. With the pandemic causing havoc for the second straight year, the findings in our paper will allow researchers worldwide to use and create state-of-the-art models to detect affected persons before it reaches the R number. The paper proposes an automated diagnostic tool using the deep learning models on chest x-rays as an input to reach a point where we surpass this pandemic (COVID-19 disease). A deep transfer learning-based model for automatic detection of COVID-19 from chest …
Deep Learning-Based Covid-19 Detection System Using Pulmonary Ct Scans, Rajit Nair, Adi Alhudhaif, Deepika Koundal, Rumi Iqbal Doewes, Preeti Sharma
Deep Learning-Based Covid-19 Detection System Using Pulmonary Ct Scans, Rajit Nair, Adi Alhudhaif, Deepika Koundal, Rumi Iqbal Doewes, Preeti Sharma
Turkish Journal of Electrical Engineering and Computer Sciences
One of the most significant pandemics has been raised in the form of Coronavirus disease 2019 (COVID19). Many researchers have faced various types of challenges for finding the accurate model, which can automatically detect the COVID-19 using computed pulmonary tomography (CT) scans of the chest. This paper has also focused on the same area, and a fully automatic model has been developed, which can predict the COVID-19 using the chest CT scans. The performance of the proposed method has been evaluated by classifying the CT scans of community-acquired pneumonia (CAP) and other non-pneumonia. The proposed deep learning model is based …