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- 2-selenouridine triphosphate; RNA transcription; RNA structure and function; hammerhead ribozyme; RNA crystallography (1)
- Adaptive methods (1)
- Calcium; Calcium binding proteins; Drug discovery; G protein coupled receptors (GPCR); Glutamate receptors metabotropic; allosteric modulators; orthosteric agonist; orthosteric antagonist (1)
- Clinical trial design (1)
- Density functional theory (1)
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Articles 1 - 27 of 27
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Magneto-Transport Characteristics Of A 2d Electron System Driven To Negative Magneto-Conductivity By Microwave Photoexcitation, Ramesh G. Mani, Annika Kriisa
Magneto-Transport Characteristics Of A 2d Electron System Driven To Negative Magneto-Conductivity By Microwave Photoexcitation, Ramesh G. Mani, Annika Kriisa
Physics and Astronomy Faculty Publications
Negative diagonal magneto-conductivity/resistivity is a spectacular- and thought provoking-property of driven, far-from-equilibrium, low dimensional electronic systems. The physical response of this exotic electronic state is not yet fully understood since it is rarely encountered in experiment. The microwave-radiation-induced zero-resistance state in the high mobility GaAs/AlGaAs 2D electron system is believed to be an example where negative magneto-conductivity/resistivity is responsible for the observed phenomena. Here, we examine the magneto-transport characteristics of this negative conductivity/ resistivity state in the microwave photo-excited two-dimensional electron system (2DES) through a numerical solution of the associated boundary value problem. The results suggest, surprisingly, that a bare …
Extracellular Calcium Modulates Actions Of Orthosteric And Allosteric Ligands On Metabotropic Glutamate Receptor 1alpha, Jason Y. Jiang, Mulpuri Nagaraju, Rebecca C. Meyer, Li Zhang, Donald Hamelberg, Randy A. Hall, Edward M. Brown, P. Jeffrey Conn, Jenny J. Yang
Extracellular Calcium Modulates Actions Of Orthosteric And Allosteric Ligands On Metabotropic Glutamate Receptor 1alpha, Jason Y. Jiang, Mulpuri Nagaraju, Rebecca C. Meyer, Li Zhang, Donald Hamelberg, Randy A. Hall, Edward M. Brown, P. Jeffrey Conn, Jenny J. Yang
Chemistry Faculty Publications
SUMMARY: Metabotropic glutamate receptor 1α (mGluR1α), a member of the family C G protein-coupled receptors (GPCRs), is emerging as a potential drug target for various disorders including chronic neuronal degenerative diseases. In addition to being activated by glutamate, mGluR1α is also modulated by extracellular Ca2+. However, the underlying mechanism is unknown. Moreover, it has long been challenging to develop receptor-specific agonists due to homologies within the mGluR family, and the Ca2+-binding site(s) on mGluR1α may provide an opportunity for receptor-selective targeting by therapeutics. In the present study, we show that our previously predicted Ca2+-binding site in the hinge region of …
Is The Brain’S Inertia For Motor Movements Different For Acceleration And Deceleration?, Bhim M. Adhikari, Kristen M. Quinn, Mukesh Dhamala
Is The Brain’S Inertia For Motor Movements Different For Acceleration And Deceleration?, Bhim M. Adhikari, Kristen M. Quinn, Mukesh Dhamala
Physics and Astronomy Faculty Publications
The brain’s ability to synchronize movements with external cues is used daily, yet neuroscience is far from a full understanding of the brain mechanisms that facilitate and set behavioral limits on these sequential performances. This functional magnetic resonance imaging (fMRI) study was designed to help understand the neural basis of behavioral performance differences on a synchronizing movement task during increasing (acceleration) and decreasing (deceleration) metronome rates. In the MRI scanner, subjects were instructed to tap their right index finger on a response box in synchrony to visual cues presented on a display screen. The tapping rate varied either continuously or …
Structure-Dependent Inhibition Of The Ets-Family Transcription Factor Pu.1 By Novel Heterocyclic Diamidines, Manoj Munde, Shuo Wang, Arvind Kumar, Chad E. Stephens, Abdelbasset A. Farahat, David Boykin, W. David Wilson, Gregory M. K. Poon
Structure-Dependent Inhibition Of The Ets-Family Transcription Factor Pu.1 By Novel Heterocyclic Diamidines, Manoj Munde, Shuo Wang, Arvind Kumar, Chad E. Stephens, Abdelbasset A. Farahat, David Boykin, W. David Wilson, Gregory M. K. Poon
Chemistry Faculty Publications
ETS transcription factors mediate a wide array of cellular functions and are attractive targets for pharmacological control of gene regulation. We report the inhibition of the ETS-family member PU.1 with a panel of novel heterocyclic diamidines. These diamidines are derivatives of furamidine (DB75) in which the central furan has been replaced with selenophene and/or one or both of the bridging phenyl has been replaced with benzimidazole. Like all ETS proteins, PU.1 binds sequence specifically to 10-bp sites by inserting a recognition helix into the major groove of a 50-GGAA-30 consensus, accompanied by contacts with the flanking minor groove. We showed …
Size-Dependent Giant-Magnetoresistance In Millimeter Scale Gaas/Algaas 2d Electron Devices, Ramesh G. Mani, Annika Kriisa, Werner Wegscheider
Size-Dependent Giant-Magnetoresistance In Millimeter Scale Gaas/Algaas 2d Electron Devices, Ramesh G. Mani, Annika Kriisa, Werner Wegscheider
Physics and Astronomy Faculty Publications
Large changes in the electrical resistance induced by the application of a small magnetic field are potentially useful for device-applications. Such Giant Magneto-Resistance (GMR) effects also provide new insights into the physical phenomena involved in the associated electronic transport. This study examines a ‘‘bell-shape’’ negative GMR that grows inmagnitude with decreasing temperatures inmm-wide devices fabricated from the high-mobility GaAs/AlGaAs 2-Dimensional Electron System (2DES). Experiments show that the span of this magnetoresistance on the magnetic-field-axis increases with decreasing device width, W, while there is no concurrent Hall resistance, Rxy, correction. A multi-conduction model, including negative diagonalconductivity, and non-vanishing off-diagonal conductivity, reproduces …
Opening Pathways Of The Dna Clamps Proliferating Cell Nuclear Antigen And Rad9-Rad1-Hus1, Xiaojun Xu, Carlo Guardiani, Chunli Yan, Ivaylo Nikolaev Ivanov
Opening Pathways Of The Dna Clamps Proliferating Cell Nuclear Antigen And Rad9-Rad1-Hus1, Xiaojun Xu, Carlo Guardiani, Chunli Yan, Ivaylo Nikolaev Ivanov
Chemistry Faculty Publications
No abstract provided.
Structural Insights Of Non-Canonical U*U Pair And Hoogsteen Interaction Probed With Se Atom, Jia Sheng, Jianhua Gan, Alexei S. Soares, Jozef Salon, Zhen Huang
Structural Insights Of Non-Canonical U*U Pair And Hoogsteen Interaction Probed With Se Atom, Jia Sheng, Jianhua Gan, Alexei S. Soares, Jozef Salon, Zhen Huang
Chemistry Faculty Publications
Unlike DNA, in addition to the 20 -OH group, uracil nucleobase and its modifications play essential roles in structure and function diversities of non- coding RNAs. Non-canonical U.U base pair is ubiquitous in non-coding RNAs, which are highly diversified. However, it is not completely clear how uracil plays the diversifing roles. To investigate and compare the uracil in U-A and U.U base pairs, we have decided to probe them with a selenium atom by synthesizing the novel 4-Se-uridine (SeU) phosphoramidite and Se-nucleobase-modified RNAs (SeU-RNAs), where the exo-4-oxygen of uracil is replaced by selenium. Our crystal structure studies of U-A and …
Comparison Of Calculated And Experimental Isotope Edited Ftir Difference Spectra For Purple Bacterial Photosynthetic Reaction Centers With Different Quinones Incorporated Into The Qa Binding Site, Nan Zhao, Hari Prasad Lamichhane, Gary Hastings
Comparison Of Calculated And Experimental Isotope Edited Ftir Difference Spectra For Purple Bacterial Photosynthetic Reaction Centers With Different Quinones Incorporated Into The Qa Binding Site, Nan Zhao, Hari Prasad Lamichhane, Gary Hastings
Physics and Astronomy Faculty Publications
Previously we have shown that ONIOM type (QM/MM) calculations can be used to simulate isotope edited FTIR difference spectra for neutral ubiquinone in the QA binding site in Rhodobacter sphaeroides photosynthetic reaction centers. Here we considerably extend upon this previous work by calculating isotope edited FTIR difference spectra for reaction centers with a variety of unlabeled and 18 O labeled foreign quinones incorporated into the QA binding site. Isotope edited spectra were calculated for reaction centers with 2,3-dimethoxy-5,6-dimethyl-1,4-benzoquinone (MQ0 ), 2,3,5,6-tetramethyl-1, 4-benzoquinone (duroquinone, DQ), and 2,3-dimethyl-l,4-naphthoquinone (DMNQ) incorporated, and compared to corresponding experimental spectra. The calculated and experimental spectra agree …
2-Selenouridine Triphosphate Synthesis And Se-Rna Transcription, Huiyan Sun, Sibo Jiang, Julianne Caton-Williams, Hehua Liu, Zhen Huang
2-Selenouridine Triphosphate Synthesis And Se-Rna Transcription, Huiyan Sun, Sibo Jiang, Julianne Caton-Williams, Hehua Liu, Zhen Huang
Chemistry Faculty Publications
2-Selenouridine (SeU) is one of the naturally occurring modifications of Se-tRNAs (SeU-RNA) at the wobble position of the anticodon loop. Its role in the RNA-RNA interaction, especially during the mRNA decoding, is elusive. To assist the research exploration, herein we report the enzymatic synthesis of the SeU-RNA via 2-selenouridine triphosphate (SeUTP) synthesis and RNA transcription. Moreover, we have demonstrated that the synthesized SeUTP is stable and recognizable by T7 RNA polymerase. Under the optimized conditions, the transcription yield of SeU-RNA can reach up to 85% of the corresponding native RNA. Furthermore, the transcribed SeU-hammerhead ribozyme has the similar activity as …
Higher Frequency Network Activity Flow Predicts Lower Frequency Node Activity In Intrinsic Low-Frequency Bold Fluctuations, Sahil Bajaj, Bhim M. Adhikari, Mukesh Dhamala
Higher Frequency Network Activity Flow Predicts Lower Frequency Node Activity In Intrinsic Low-Frequency Bold Fluctuations, Sahil Bajaj, Bhim M. Adhikari, Mukesh Dhamala
Physics and Astronomy Faculty Publications
The brain remains electrically and metabolically active during resting conditions. The low-frequency oscillations (LFO) of the blood oxygen level-dependent (BOLD) signal of functional magnetic resonance imaging (fMRI) coherent across distributed brain regions are known to exhibit features of this activity. However, these intrinsic oscillations may undergo dynamic changes in time scales of seconds to minutes during resting conditions. Here, using wavelet-transform based timefrequency analysis techniques, we investigated the dynamic nature of default-mode networks from intrinsic BOLD signals recorded from participants maintaining visual fixation during resting conditions. We focused on the default-mode network consisting of the posterior cingulate cortex (PCC), the …
A Mathematical Model Of The Mouse Ventricular Myocyte Contraction, Paula D. Mullins, Vladimir Bondarenko
A Mathematical Model Of The Mouse Ventricular Myocyte Contraction, Paula D. Mullins, Vladimir Bondarenko
Mathematics and Statistics Faculty Publications
Mathematical models of cardiac function at the cellular level include three major components, such as electrical activity, Ca2+ dynamics, and cellular shortening. We developed a model for mouse ventricular myocyte contraction which is based on our previously published comprehensive models of action potential and Ca2+ handling mechanisms. The model was verified with extensive experimental data on mouse myocyte contraction at room temperature. In the model, we implemented variable sarcomere length and indirect modulation of the tropomyosin transition rates by Ca2+ and troponin. The resulting model described well steady-state force-calcium relationships, dependence of the contraction force on the sarcomere length, time …
Quantitative Community Geography: A Preliminary Evaluation Of Nitrogen Dioxide Levels And Possible Solutions To Exposure Rates In Npu-V, Atlanta, Ga, Alyssa M. Combs, Maria C. Martinez, Kumar K. Amarnath, Hannah Kaplan, Mary Winsor, Rebecca A. Pickering
Quantitative Community Geography: A Preliminary Evaluation Of Nitrogen Dioxide Levels And Possible Solutions To Exposure Rates In Npu-V, Atlanta, Ga, Alyssa M. Combs, Maria C. Martinez, Kumar K. Amarnath, Hannah Kaplan, Mary Winsor, Rebecca A. Pickering
Georgia State Undergraduate Research Conference
No abstract provided.
Polynomial Functions Over Finite Fields, John J. Hull
Polynomial Functions Over Finite Fields, John J. Hull
Georgia State Undergraduate Research Conference
No abstract provided.
The Effect Of The R1648h Sodium Channel Mutation On Neuronal Excitability: A Model Study, Christopher Locandro, Robert Clewley
The Effect Of The R1648h Sodium Channel Mutation On Neuronal Excitability: A Model Study, Christopher Locandro, Robert Clewley
Georgia State Undergraduate Research Conference
No abstract provided.
Effects Of Carbonate Brines On Cation Exchange And Clay Interstratification, Lucy C. Taylor, Peter Razumov, Rebecca A. Pickering, Daniel M. Deocampo
Effects Of Carbonate Brines On Cation Exchange And Clay Interstratification, Lucy C. Taylor, Peter Razumov, Rebecca A. Pickering, Daniel M. Deocampo
Georgia State Undergraduate Research Conference
No abstract provided.
Temporal Dynamics Of Neural Activity In The Olfactory Receptor Neurons During Odor Exposure, Danni Liu, Jun Xia
Temporal Dynamics Of Neural Activity In The Olfactory Receptor Neurons During Odor Exposure, Danni Liu, Jun Xia
Georgia State Undergraduate Research Conference
No abstract provided.
Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr.
Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr.
Georgia State Undergraduate Research Conference
No abstract provided.
Clay Synthesis: Modeling The Uptake Of Potassium During Low Temperature Illitization Of Smectite, Peter M. Razumov, Lucy C. Taylor, Rebecca A. Pickering
Clay Synthesis: Modeling The Uptake Of Potassium During Low Temperature Illitization Of Smectite, Peter M. Razumov, Lucy C. Taylor, Rebecca A. Pickering
Georgia State Undergraduate Research Conference
No abstract provided.
Analytical Evaluation Of Expected Values And Variances Of The Targeting Performances For A Simplified Neural Growth Model, Adil Virani, Jun Xia, Gloria Sanin
Analytical Evaluation Of Expected Values And Variances Of The Targeting Performances For A Simplified Neural Growth Model, Adil Virani, Jun Xia, Gloria Sanin
Georgia State Undergraduate Research Conference
No abstract provided.
Spectroscopic Study Of 4-Methoxychalcone And Human Serum Albumin: Binding Interaction, Rosalind Usher
Spectroscopic Study Of 4-Methoxychalcone And Human Serum Albumin: Binding Interaction, Rosalind Usher
Georgia State Undergraduate Research Conference
No abstract provided.
Determination Of The Cec In Srs Soils And The Capability Of Epa Model 9081 For Cec Of Acidic Soils, Alexandra M. Simpson
Determination Of The Cec In Srs Soils And The Capability Of Epa Model 9081 For Cec Of Acidic Soils, Alexandra M. Simpson
Georgia State Undergraduate Research Conference
No abstract provided.
Resiliency To Bistability In The Neurons From The Pre-Bötzinger Complex, Treadwell D. Singfield Ii
Resiliency To Bistability In The Neurons From The Pre-Bötzinger Complex, Treadwell D. Singfield Ii
Georgia State Undergraduate Research Conference
No abstract provided.
Automated Homebrewing System Controlled By An Android Device, Djuan K. Blue Jr
Automated Homebrewing System Controlled By An Android Device, Djuan K. Blue Jr
Georgia State Undergraduate Research Conference
No abstract provided.
Synthesis And Evaluation Of Carbocyanine Dyes As Prmt Inhibitors And Imaging Agents, Amber E. Howard
Synthesis And Evaluation Of Carbocyanine Dyes As Prmt Inhibitors And Imaging Agents, Amber E. Howard
Georgia State Undergraduate Research Conference
No abstract provided.
Calculated Vibrational Properties Of Ubisemiquinones, Hari P. Lamichhane, Gary Hastings
Calculated Vibrational Properties Of Ubisemiquinones, Hari P. Lamichhane, Gary Hastings
Physics and Astronomy Faculty Publications
Density functional theory has been used to calculate harmonic normal mode vibrational frequencies for unlabeled and isotopelabeled ubisemiquinones in both the gas phase and in several solvents. It is shown that four methoxy group conformations are likely to be present in solution at room temperature. Boltzmann weighted infrared and Raman spectra for the four conformers were calculated, and composite spectra that are the sum of the Boltzmann weighted spectra were produced. These composite spectra were compared to experimental FTIR and resonance Raman spectra, and it is shown that the calculated band frequencies, relative band intensities, and 13C and 18 …
Conformational Plasticity Of An Enzyme During Catalysis: Intricate Coupling Between Cyclophilin A Dynamics And Substrate Turnover, Lauren C. Mcgowan, Donald Hamelberg
Conformational Plasticity Of An Enzyme During Catalysis: Intricate Coupling Between Cyclophilin A Dynamics And Substrate Turnover, Lauren C. Mcgowan, Donald Hamelberg
Chemistry Faculty Publications
Enzyme catalysis is central to almost all biochemical processes, speeding up rates of reactions to biological relevant timescales. Enzymes make use of a large ensemble of conformations in recognizing their substrates and stabilizing the transition states, due to the inherent dynamical nature of biomolecules. The exact role of these diverse enzyme conformations and the interplay between enzyme conformational dynamics and catalysis is, according to the literature, not well understood. Here, we use molecular dynamics simulations to study human cyclophilin A (CypA), in order to understand the role of enzyme motions in the catalytic mechanism and recognition. Cyclophilin A is a …
Adaptive And Sequential Methods For Clinical Trials, Yichuan Zhao, Zhengjia Chen, Xuelin Huang, Mourad Tighiouart
Adaptive And Sequential Methods For Clinical Trials, Yichuan Zhao, Zhengjia Chen, Xuelin Huang, Mourad Tighiouart
Mathematics and Statistics Faculty Publications
This special issue describes state-of-the-art statistical research in adaptive and sequential methods and the application of such methods in clinical trials. It provides 1 review article and 5 research articles contributed by some of the leading experts in this field. The review article gives a comprehensive overview of the outstanding methodology in the current literature that is related to adaptive and sequential clinical trials, while each of the 5 research articles addresses specific critical issues in contemporary clinical trials, as summarized below.