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Long-Residency Hydration, Cation Binding, And Dynamics Of Loop E/Helix Iv Rrna-L25 Protein Complex, Neocles B. Leontis, Kamila Réblová, Nad'a Špačková, Jaroslav Koča, Jiří Šponer
Long-Residency Hydration, Cation Binding, And Dynamics Of Loop E/Helix Iv Rrna-L25 Protein Complex, Neocles B. Leontis, Kamila Réblová, Nad'a Špačková, Jaroslav Koča, Jiří Šponer
Chemistry Faculty Publications
Molecular dynamics simulations of RNA-protein complex between Escherichia coli loop E/helix IV (LE/HeIV) rRNA and L25 protein reveal a qualitative agreement between the experimental and simulated structures. The major groove of LE is a prominent rRNA cation-binding site. Divalent cations rigidify the LE major groove geometry whereas in the absence of divalent cations LE extensively interacts with monovalent cations via inner-shell binding. The HeIV region shows bistability of its major groove explaining the observed differences between x-ray and NMR structures. In agreement with the experiments, the simulations suggest that helix-alpha1 of L25 is the least stable part of the protein. …
Sensing Of Aqueous Phosphates By Polymers With Dual Modes Of Signal Transduction, Dmitry Aldakov, Pavel Anzenbacher Jr.
Sensing Of Aqueous Phosphates By Polymers With Dual Modes Of Signal Transduction, Dmitry Aldakov, Pavel Anzenbacher Jr.
Chemistry Faculty Publications
A new approach to sensing of aqueous phosphate-related anions based on chromogenic conductive polymers is demonstrated. This method utilizes synergy between low-level p-doping in a polythiophene polymer and hydrogen bonding to increase anion-sensor affinity. These chromogenic conductive polymers show anion-specific changes both in color and in conductivity upon increasing concentration of anions, thus providing two independent modes of signal transduction.
Red-Green-Blue Emission From Tris(5-Aryl-8-Quinolinolate)Al(Iii) Complexes, Radek Pohl, Victor A. Montes, Joseph Shinar, Pavel Anzenbacher Jr.
Red-Green-Blue Emission From Tris(5-Aryl-8-Quinolinolate)Al(Iii) Complexes, Radek Pohl, Victor A. Montes, Joseph Shinar, Pavel Anzenbacher Jr.
Chemistry Faculty Publications
A simple yet effective strategy for synthesis of 5-aryl-8-quinolinolate-based electroluminophores with tunable emission wavelengths is presented. Two different pathways for the attachment of electron-donating or electron-withdrawing aryl groups to the 5-position of the quinolinolate ligand via Suzuki coupling were developed. A successful tuning in the emission color was achieved: the emission wavelength was found to correlate with the Hammett constant of the respective substituents, providing a powerful strategy for prediction of the optical properties of new electroluminophores.
Gated Electron Transfer As A Probe Of The Configurational Dynamics Of Peptide-Protein Complexes, Liu Liu, Jing Hong, Michael Y. Ogawa
Gated Electron Transfer As A Probe Of The Configurational Dynamics Of Peptide-Protein Complexes, Liu Liu, Jing Hong, Michael Y. Ogawa
Chemistry Faculty Publications
Gated electron-transfer measurements are used to probe the configurational dynamics of complexes formed between small metallopeptides and cytochrome c. The results show that that an apparently subtle chemical alteration of the metallopeptide produces significant changes to the dynamics of the peptide−protein complex.