Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Mir-103a-3p Targets The 5' Utr Of Gprc5a In Pancreatic Cells., Honglei Zhou, Isidore Rigoutsos
Mir-103a-3p Targets The 5' Utr Of Gprc5a In Pancreatic Cells., Honglei Zhou, Isidore Rigoutsos
Computational Medicine Center Faculty Papers
MicroRNAs (miRNAs) are short noncoding RNAs that regulate the expression of their targets in a sequence-dependent manner. For protein-coding transcripts, miRNAs regulate expression levels through binding sites in either the 3' untranslated region (3' UTR) or the amino acid coding sequence (CDS) of the targeted messenger RNA (mRNA). Currently, for the 5' untranslated region (5' UTR) of mRNAs, very few naturally occurring examples exist whereby the targeting miRNA down-regulates the expression of the corresponding mRNA in a seed-dependent manner. Here we describe and characterize two miR-103a-3p target sites in the 5' UTR of GPRC5A, a gene that acts as a …