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Movie-Driven Fmri Reveals Network Asynchrony And Connectivity Alterations In Temporal Lobe Epilepsy, Alenka Bullen
Movie-Driven Fmri Reveals Network Asynchrony And Connectivity Alterations In Temporal Lobe Epilepsy, Alenka Bullen
Electronic Thesis and Dissertation Repository
Mesial temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and is often resistant to medication. Recent studies have noted brain-wide disruptions to several neural networks in so-called “focal” epilepsy, notably TLE, leading to it being recognized as a network disease. We aimed to assess the integrity of functional networks while they were simultaneously activated in an ecologically valid manner, using an actively engaging, richly stimulating audio-visual film clip. This stimulus elicits widespread, dynamic patterns of time-locked brain activity, measurable using functional magnetic resonance imaging. Thirteen persons with drug-resistant TLE (persons with epilepsy; PWE) and 10 demographically …
A Naturalistic Paradigm To Probe Conscious Information Processing During Sleep, Max M. Silverbrook
A Naturalistic Paradigm To Probe Conscious Information Processing During Sleep, Max M. Silverbrook
Electronic Thesis and Dissertation Repository
Sleep was long considered a passive mental state. The extent to which external information is integrated in, and consciously processed during sleep remains unknown. Here, simultaneous electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) data were collected from sleeping participants. First, the stimulus elicited significantly correlated fMRI activity in the auditory and fronto-parietal networks of awake participants. Behavioural testing found individuals to perceive the story’s suspense similarly. Then neural activity related to high-level processing of the story was investigated in 5 individuals who slept through it. Fronto-parietal activity in 1 individual in rapid eye movement (REM) sleep followed that of …