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Apoptosis;; hypomagnesemia;; inflammation;; nephrotoxicity;; oxidative;; stress;; ORGANIC CATION TRANSPORTER-2;; INDUCED RENAL INJURY;; INDUCED;; NEPHROTOXICITY;; OXIDATIVE STRESS;; INFLAMMATORY RESPONSE;; TESTICULAR;; CANCER;; GENE-EXPRESSION;; DEFICIENT RATS;; CELL APOPTOSIS;; BLOOD-PRESSURE;; Physiology;; Urology & Nephrology
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Magnesium Protects Against Cisplatin-Induced Acute Kidney Injury By Regulating Platinum Accumulation, M. H. Solanki, P. K. Chatterjee, M. Gupta, X. Y. Xue, A. Plagov, M. H. Metz, R. Mintz, P. C. Singhal, C. N. Metz
Magnesium Protects Against Cisplatin-Induced Acute Kidney Injury By Regulating Platinum Accumulation, M. H. Solanki, P. K. Chatterjee, M. Gupta, X. Y. Xue, A. Plagov, M. H. Metz, R. Mintz, P. C. Singhal, C. N. Metz
Journal Articles
Despite its success as a potent antineoplastic agent, similar to 25% of patients receiving cisplatin experience acute kidney injury (AKI) and must discontinue therapy. Impaired magnesium homeostasis has been linked to cisplatin-mediated AKI, and because magnesium deficiency is widespread, we examined the effect of magnesium deficiency and replacement on cisplatin-induced AKI in physiologically relevant older female mice. Magnesium deficiency significantly increased cisplatin-associated weight loss and markers of renal damage (plasma blood urea nitrogen and creatinine), histological changes, inflammation, and renal cell apoptosis and modulated signaling pathways (e.g., ERK1/2, p53, and STAT3). Conversely, these damaging effects were reversed by magnesium. Magnesium …