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Assessment Of The Efficacy And Safety Of Platelet-Poor Plasma Gel As Autologous Dermal Filler For Facial Rejuvenation, Amira F M. El-Sandebisi, Mohammed A El-Wahed Gaber, Ola H A. El-Shafey

Menoufia Medical Journal

Objective This study was designed to evaluate the clinical efficacy and safety of plasma gel as a dermal-filler injection for facial rejuvenation. Background The popularity of dermal fillers has grown rapidly in the last few years for facial rejuvenation. Plasma gel is an autologous gelatinous material that is prepared from the patient's own platelet-poor plasma (PPP). Plasma gel had gained popularity in plastic surgery, orthopedic surgery, oral surgery, and various other fields. Patients and methods A cross-sectional study was carried out on 200 females more than 40 years presented with facial aging. They were divided into two main groups: group …

Hyperopic Peripapillary Retinal Nerve Fiber Layer Thickness And Foveal Thickness Using Optical Coherence Tomography, Asmaa M. A. Ibrahim, Eman N. El Gohary, Hoda M. El Sobky

Menoufia Medical Journal

Purpose Studying the peripapillary retinal nerve fiber layer (RNFL) thickness and foveal thickness in hyperopia using optical coherence tomography. Background Significant hyperopia is defined to be any degree of hyperopia sufficient to cause symptoms requiring remediation. Peripapillary RNFL thickness was approved to be conversely correlated with axial length (AL) and the spherical equivalent in hyperopic populations. Optical coherence tomography is a modern noncontact and noninvasive imaging technique designed to produce high-resolution images and accurate measurements of the different retinal components. Patients and methods The presented study included ninety eyes: 45 of them were simple hyperopic eyes, and the other 45 …

Dermatologists In The Wild West, 1870-1900: The Early Pioneers From The Mississippi River To The Pacific Coast., Leonard J Hoenig, Lawrence Charles Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

During the Wild West era of American history (approximately 1870-1900), at least 53 dermatologists settled between the Mississippi River and the Pacific Coast. In 1870, two dermatologists began their practice in the city of St Louis, Missouri (William Augustus Hardaway and Solomon Claiborne Martin, Sr) and one dermatologist started his practice in San Francisco, California (George J. Bucknall). By 1900, 50 more dermatologists had settled in 19 cities located in the American West (Tables 1,2). There, they established practices, initiated academic programs, and pioneered dermatology as a medical specialty in the western United States. This contribution provides brief biographic profiles …

Differentiation Of Mesenchymal Stem Cells Into Chondrocytes As A Future Therapy For Skeletal Diseases, Maha M. Elbatsh, Rasha I. Noreldin, Rawhia H. Eledel, Thoria A. Omar, Zahraa A.M. Abu-Alata

Menoufia Medical Journal

Objective The aim of this study was to assess the ability of mesenchymal stem cells (MSCs) to differentiate into chondrocytes in vitro. Background MSCs with their ability of self-renewal and multilineage differentiation can differentiate into several types of cells including chondrocytes. It is reported that adult cartilage lacks the ability to repair itself, making articular cartilage a very attractive target for regenerative medicine therapy. Materials and methods This study was conducted at Clinical Pathology, Gynecology and Obstetrics Departments, Menoufia University Hospital, from December 2016 to May 2018, and included a collection of 30 umbilical cord samples under complete aseptic …

Isolation And Osteogenic Differentiation Of Umbilical Cord Mesenchymal Stem Cells, Alaa M. Abd El-Gayed, Asmaa Z.A. Turky, Mona M. Hassouna, Rasha I. Noreldin, Rawhia H. El-Edel

Menoufia Medical Journal

Objective To investigate the isolation and in-vitro differentiation of umbilical cord mesenchymal stem cells (MSC) into osteocytes. Background Umbilical cord is an important source of multiple cell types such as MSCs that possess the ability of self-renewal and differentiation into several cell types including osteocytes. Bone healing is a complex process that can eventually lead to the formation of malunions, delayed unions, and osteomyelitis. Cellular therapy and bone tissue engineering are becoming a useful addition to medical therapies for bone repairing and restoring function which is a potential tool for the treatment of multiple bone diseases. Patients and methods The …

Slc36a1-Mtorc1 Signaling Drives Acquired Resistance To Cdk4/6 Inhibitors., Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée De Leeuw, Karen E. Knudsen, J. Alan Diehl

Department of Cancer Biology Faculty Papers

The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic target. CDK4/6 inhibitors are being evaluated in trials for melanoma and additional cancers. While beneficial, resistance to therapy is a concern, and the molecular mechanisms of such resistance remain undefined. We demonstrate that reactivation of mammalian target of rapamycin 1 (mTORC1) signaling through increased expression of the amino acid transporter, solute carrier family 36 member 1 (SLC36A1), drives resistance to CDK4/6 inhibitors. Increased expression of SLC36A1 reflects two distinct mechanisms: (i) Rb loss, which drives SLC36A1 via reduced suppression of E2f; (ii) fragile X …

The Pulse, Volume 08, No. 9, 1914, University Of Nebraska College Of Medicine

The Pulse

•Nebraska Methodist Hospital

•Pemphigus Foliacus by Alfred Schalek, A.M., M.D.

•Alumni News Notes

•The Sero Diagnosis of Pregnancy by Palmer Findley, M.D.

•Editorial: Professor Emil Abderhalden

•The Banquet of the Pre-Medics

•The Dance

•Toast Delivered by Dr. C.W.M. Poynter at the Pre-Medic Banquet in Lincoln

•Fun for the Doctor

•Senior Notes

•Freshman Notes

•Junior Notes

•Sophomore Notes

•Some Communications

•From a Recent Medical Harold

•The Dinsplitter Hunter

•The Whiffle-Bat Fisherman