Digital Commons Network^™

Survey Of Certified Asthma Educator (Ae-C) Pharmacists – Who Are They And How Is This Credential Being Used?, Timothy R. Hudd, Susan G. Bollmeier, Enrique Seoane-Vazquez

Pharmacy Faculty Articles and Research

Objective: A survey was developed and distributed to pharmacists who have earned the certified asthma educator credential (AE-C) to assess asthma education services provided and their perceived value of the AE-C.

Design: A 28 item survey was developed, pretested and distributed electronically.

Participants: 224 AE-C certified pharmacists practicing within the United States were invited to participate.

Main Outcome Measures: Information pertaining to the level of education, professional affiliations, and practice setting was collected along with other demographic attributes.We also inquired about the types of asthma education services provided, related clinical activities, and whether AE-C pharmacists or …

Asthma In Focus, Shaunta' M. Ray, Sarah Nisly

Sarah A. Nisly

Book review of Asthma in Focus, by Anna Murphy.

An Evaluation Of The Effectiveness Of An Asthma Educational Initiative In A Rural Clinic, Denise Trujillo

Regis University Student Publications (comprehensive collection)

Executive Summary An Evaluation of the Effectiveness of an Educational Initiative in a Rural Clinic Problem According to the American Lung Association (2011), approximately one third of the children hospitalized in the state of Colorado are due to asthma. In fact, almost 75% of admissions for asthma are avoidable, and potentially preventable factors are common in deaths from asthma. Asthma is a chronic disease that can be managed through education, medication, and avoidance of triggers. The PICO question this capstone project seeked to address was: In (Population) parents of children clinically diagnosed with asthma in a rural clinic, will (Intervention) …

Two Studies Of Family-Centered Care Family-Centered Care And Shared Decision Making: Are They The Same Construct? And The Association Of Family-Centered Care And Shared Decision Making With Receipt Of All Needed Prescription Drugs And Emergency Department Visits In Children With Asthma, Barbara Lee Brumbaugh

Theses and Dissertations

Family-Centered Care (FCC) is considered the standard of care in pediatrics, being affirmed in 2003 by the American Academy of Pediatrics (AAP). Family centered practices center around five specific provider actions: (1) did the provider spend enough time; (2) did the provider listen carefully; (3) was the provider sensitive to the needs of the family, including their values and customs; (4) did the provider provide information as needed; (5) did the provider make the caregiver feel like a partner in the care of the child. In addition to FCC practices, shared decision making (SDM) has been indicated as important in …

Role Of Allergic Sensitization, Filaggrin Variants, And Dna, Ali H. Ziyab

Theses and Dissertations

Background: Allergic disorders, including eczema, asthma, and rhinitis, have emerged as a global public health concern due to their elevated prevalence and the associated clinical morbidity. Environmental, immunologic, and genetic factors have been implicated in the pathogenesis of allergic disorders. Allergic sensitization (representing deviated immune responses) and filaggrin gene (FLG) variants (leading to dysfunctional epidermal barrier) have shown to be common predisposing factors in the development of allergic disorders. However, there is a lack of knowledge on their joint effects on the development of single and multiple (coexistence) allergic disorders. More recently, epigenetic mechanisms, such as DNA methylation, have emerged …

Geospatial Relationships Of Air Pollution And Acute Asthma Events Across The Detroit–Windsor International Border: Study Design And Preliminary Results, Lawrence D. Lemke, Lois E. Lamerato, Xiaohong Xu, Jason C. Booza, John J. Reiners Jr., Delbert M. Raymond Iii, Paul J. Villeneuve, Eric Lavigne, Dana Larkin, Helene J. Krouse

School of Medicine Publications and Presentations

The Geospatial Determinants of Health Outcomes Consortium (GeoDHOC) study investigated ambient air quality across the international border between Detroit, Michigan, USA and Windsor, Ontario, Canada and its association with acute asthma events in 5- to 89-year-old residents of these cities. NO2, SO2, and volatile organic compounds (VOCs) were measured at 100 sites, and particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) at 50 sites during two 2-week sampling periods in 2008 and 2009. Acute asthma event rates across neighborhoods in each city were calculated using emergency room visits and hospitalizations and standardized to the overall age and gender distribution of …

Low Magnesium Concentration In Erythrocytes Of Children With Acute Asthma, Ahmed Anwar Khatab, Fahima Mohammed Hassane, Mohammed Saber Fahmy, Sherif Salah Saliem

Menoufia Medical Journal

Objectives Magnesium (Mg) is thought to be an important element in the pathogenesis of acute asthma attacks. This study aimed at investigating plasma and erythrocyte Mg of acute asthmatic children and correlating them with asthma severity. Background Continuous efforts are still exerted to understand the natural history and pathogenesis of acute asthma to alleviate its burden on children and their families. Mg is an abundant intracellular cation. It is involved in numerous physiological functions, including protein folding, intracellular signaling, enzymatic reactions involving protein and nucleic acid metabolisms, and enzyme catalysis. Mg is involved in pathophysiological reactions related to asthma; it …

Household Reporting Of Childhood Respiratory Health And Air Pollution In Rural Alaska Native Communities, Desirae N. Ware, Johnnye Lewis, Scarlett Hopkins, Bert Boyer, Luke Montrose, Curis W. Noonan, Erin O. Semmens, Tony J. Ward

Biomedical and Pharmaceutical Sciences Faculty Publications

Background. Air pollution is an important contributor to respiratory disease in children.

Objective. To examine associations between household reporting of childhood respiratory conditions and household characteristics related to air pollution in Alaska Native communities.

Design. In-home surveys were administered in 2 rural regions of Alaska. The 12-month prevalence of respiratory conditions was summarized by region and age. Odds ratios (ORs) were calculated to describe associations between respiratory health and household and air quality characteristics.

Results. Household-reported respiratory health data were collected for 561 children in 328 households. In 1 region, 33.6% of children aged/or bronchitis. Children with these conditions …

Microbial Exposure And Asthma: Applying Strachan’S Hygiene Hypothesis To Nursing Practice, Elisabeth M. Campbell

Senior Honors Theses

The incidence of asthma has risen significantly in recent decades. Asthma is a complex disease process affected by multiple factors including environmental exposure, genetics, epigenetics, and lifestyle. In 1989, the hygiene hypothesis was proposed based on Strachan’s findings suggesting increased exposure to microbes may have protective benefits against allergic rhinitis and eczema. Since that time, research in this arena has exploded as investigators seek to establish a causal link between increased microbial exposure and decreased incidence of allergic disease. The aim of this literature review is to synthesize the current research regarding Strachan’s hygiene hypothesis and identify the nursing implications …

Pediatric Asthma Telemonitoring: Literature, Theory, And Application To Practice, Erin Christine Shankel

DNP Scholarly Projects

Asthma is one of the most prevalent and costly chronic diseases faced by Americans today. It is marked by inflammation and hyperresponsiveness of the airways which fluctuates, often unpredictably, in response to triggers. As such, it causes particular challenges symptom management, especially on the part of the patient who is tasked with dealing with these frequent fluctuations for months at a time between regularly scheduled health care appointments. This is further complicated when the patient is a child, and symptoms must be interpreted and managed second-hand by a caregiver. Uncertainty about how to manage symptoms, as well as minimization of …

Influenza And Asthma: Evaluation Of The Effectiveness Of An Evidenced-Based Intervention Bundle On The Influenza Vaccination Rates Among Asthmatic Children Age Six Months To 18 Years, Benjamin D. Malcolm

Master of Science in Nursing Theses

The American Academy of Pediatrics has begun an initiative called Accelerating Improved Care for Children with Asthma Program Chapter Quality Network Asthma Project, Phase 3 (CQN3). This project is a conscious effort to enhance the quality of life in asthmatics. One important initiative included in this project is to achieve 90% or greater influenza vaccination rates in children age six months and older with asthma. This is because children with asthma who contract influenza have increased morbidity and mortality rates than do their non-asthmatic counterparts. Studies have shown vaccination rates for these children are typically between 9 to 26%, and …

Asthma And Adaptive Functioning Among Homeless Kindergarten-Aged Children In Emergency Housing, J. J. Cutuli, Janette E. Herbers, Theresa L. Lafavor, Sandra M. Ahumada, Ann S. Masten, Charles N. Oberg

J. J. Cutuli

Background. Children who experience homelessness have elevated rates of asthma, a risk factor for other problems. Purpose. Examine rates of asthma and its relation to health care use and adaptive functioning among young children staying in family emergency shelters. Methods. Children and caregivers (N = 138) completed assessments in shelters, including measurement of child cognitive functioning, parent report of child health care service utilization and asthma diagnosis, and teacher report of child school functioning. Results. Asthma diagnosis was reported for 21% of 4‑to‑6‑year‑ old children, about twice the national and state prevalences. Children with asthma used more health care services …

Health Policy & Management News, Georgia Southern University

Health Policy & Management Department News (2011-2018)

• Childhood Asthma

Treatment Of Asthma Exacerbations With The Human-Powered Nebuliser: A Randomised Parallel-Group Clinical Trial, M Therese Lysaught, Christopher J. Hallberg, Rene Antonio Najarro, Fausto Cea Gill, Clara Villatoro, Ana Celia Diaz De Uriarte, Lars E. Olson

Institute of Pastoral Studies: Faculty Publications and Other Works

Aims: The aim of this study was to compare a low-cost, human-powered nebuliser compressor with an electric nebuliser compressor for the treatment of mild to moderate asthma exacerbations in adults and children.

Methods: This was a non-blinded, parallel-group, equivalence study, with 110 subjects between 6 and 65 years of age, conducted in the emergency department of a district hospital in Ilopango, El Salvador. Participants were assigned by random allocation to receive a 2.5-mg dose of salbutamol from the experimental human-powered nebuliser or the electric nebuliser control. All assigned participants completed treatment and were included in analysis. The study was not …

Is Oral Dexamethasone Safe And Effective For Treating Asthma Exacerbations In Pediatric Patients?, Benhamin J. Kunze

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence based medicine review is to determine whether or not a one or two dose regimen of dexamethasone (DEX) is a safe and effective treatment for asthma exacerbations in the pediatric population.

STUDY DESIGN: Review of three English language, primary randomized controlled trials (RCT) published from 2001-2008.

DATA SOURCES: Three RCTs examining the efficacy of DEX either in a single dose or one dose for two days, compared to a traditional five day regimen of prednisone (PRED).

OUTCOMES MEASURED: The studies examined the number of relapses within 10 days of …

Does The Use Of Fascial Manipulative Therapy Help To Improve Overall Asthma Quality Of Life By Descreasing Asthma Symptoms?, Christie Mecouch

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of fascial manipulative therapy helps to improve overall asthma quality of life by decreasing asthma symptoms.

STUDY DESIGN: Review of two randomized controlled trials (RCTs) and one case study, published between 2005-current, all in the English language.

DATA SOURCES: Two randomized controlled trials (RCTs) and one case study, all of which evaluate the effectiveness of fascial manipulative therapy as it pertains to asthma quality of life. All studies were found using PubMed.

OUTCOMES MEASURED: The outcomes measured were an improvement …

Correlates Of Asthma Among The Minority Population In South Bronx,New York, Veronica Chibumma Uwanaka

Walden Dissertations and Doctoral Studies

Asthma among children has become an inherent problem in many communities in the United States, especially among the minority population. The South Bronx has a large minority population and a high prevalence of asthma. However, no study to date has explored the factors associated with this high prevalence rates in this population. Drawing from theories of social ecology and environmental health, the objective of this quantitative cross-sectional study is to investigate the correlates of asthma among children in the South Bronx by studying the sociodemographic and environmental risk factors, including parental occupation; neighborhood and housing characteristics, air quality, and poverty. …

Classical And Alternative Nuclear Factor-Kappab In Epithelium: Impacts In Allergic Airway Disease And Avenues For Redox Regulation, Jane Elizabeth Tully

Graduate College Dissertations and Theses

Nuclear Factor kappaB (NF-êB) is a transcription factor whose activation is increased in settings of allergic asthma. At least two parallel NF-êB pathways exist: the classical pathway, which plays a role in inflammation and cell survival, and the alternative pathway, which regulates lymphoid cell development and organogenesis. The classical NF-êB pathway regulates inflammatory responses derived from lung epithelial cells; however, the role of the alternative pathway in lung epithelial cells remains unclear. We demonstrate that both classical and alternative NF-êB are activated in lung epithelial cells in response to multiple pro-inflammatory agonists, and siRNA-mediated knockdown of alternative NF-êB proteins largely …

Exploration Of The Genetic Epidemiology Of Asthma: A Review, With A Focus On Prevalence In Children And Adolescents In The Caribbean, A. Mohan, A. J. Roberto, B. C. Whitehill, A. Mohan, A. Kumar

Biological Sciences Faculty Publications

Asthma is a chronic disease caused by the inflammation of the main air passages of the lungs. This paper outlines a review of the published literature on asthma. While a few studies show a trend of rising asthma cases in the Caribbean region, even fewer have explored the genetic epidemiological factors of asthma. This is a literature review that seeks to sum the body of knowledge on the epidemiology of asthma. Specifically, the major objective of the literature review is to provide a unified information base on the current state of factors involved in the genetic epidemiology of asthma. The …

What Are Ventilation Defects In Asthma?, Sarah Svenningsen, Miranda Kirby, Danielle Starr, Harvey O Coxson, Nigel A M Paterson, David G Mccormack, Grace Parraga

Medical Biophysics Publications

BACKGROUND: Hyperpolarised (3)He MRI provides a way to visualise regional pulmonary functional abnormalities that in asthma are thought to be related to airway morphological abnormalities. However, the exact aetiology of ventilation defects in asthma is not well understood.

OBJECTIVE: To better understand the determinants of ventilation defects in asthma, we evaluated well-established clinical as well as (3)He MRI and X-ray CT airway measurements in healthy subjects and subjects with asthma.

METHODS: Thirty-four subjects (n=26 subjects with asthma, n=8 healthy volunteers) underwent MRI, spirometry, plethysmography, fraction of exhaled nitric oxide analysis, methacholine challenge and CT for a region-of-interest proximal to ventilation …

In Utero Exposure To Second-Hand Smoke Aggravates Adult Responses To Inhaled Irritants, Rui Xiao

LSU Doctoral Dissertations

In utero exposure to second-hand smoke (SHS) has modulatory effects on adult lung responses to various irritants. To further elucidate diverse responses with different inhaled irritants and to understand how long the effects persist, we have focused on two environmentally-relevant and asthma-associated irritants--SHS and ovalbumin (OVA)--for adult mice that had been exposed in utero to SHS. We hypothesized that in utero SHS exposure aggravates lung responses to various inhaled irritants, including SHS and OVA, in adult mice beyond the age of 15 weeks; and that the responses will likely exhibit a sex bias. Pregnant BALB/c mice were exposed (days 6-19 …

Modulation Of The Immune Response To Aspergillus Fumigatus By Antibodies To Conserved Bacterial Polysaccharides, Emily Stefanov

All ETDs from UAB

The incidence of asthma, allergies and autoimmune diseases has increased dramatically in developed countries. The hygiene hypothesis postulates that excessively sanitary conditions lead to a lack of critical immune stimulation during early life, leading to inappropriate responses to self or harmless antigens later in life. Many bacteria and potential allergens share common polysaccharide epitopes. We investigated the ability of antibodies against these shared polysaccharides to dampen the immune response to the ubiquitous fungus and potent allergen, Aspergillus fumigatus. We found that antibodies against these polysaccharides, specifically of the IgM isotype, induced by neonatal bacterial immunization or passive antibody transfer, dampened …