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Upregulation Of Fibronectin And The Α5Β1 And Αvβ3 Integrins On Blood Vessels Within The Cerebral Ischemic Penumbra, Louise D. Mccullough, Fudong Liu
Upregulation Of Fibronectin And The Α5Β1 And Αvβ3 Integrins On Blood Vessels Within The Cerebral Ischemic Penumbra, Louise D. Mccullough, Fudong Liu
UCHC Articles - Research
Following focal cerebral ischemia, blood vessels in the ischemic border, or penumbra, launch an angiogenic response. In light of the critical role for fibronectin in angiogenesis, and the observation that fibronectin and its integrin receptors are strongly upregulated on angiogenic vessels in the hypoxic CNS, the aim of this study was to establish whether angiogenic vessels in the ischemic CNS also show this response. Focal cerebral ischemia was established in C57/Bl6 mice by middle cerebral artery occlusion (MCA:O), and brain tissue analyzed seven days following re-perfusion, a time at which angiogenesis is ongoing. Within the ischemic core, immunofluorescent (IF) studies …