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Possible Pathologic Effect Of Hmgb1 On P. Gingivalis Induced Inflammatory Response By Macrophages, Michelle Marie Torres Santos
Possible Pathologic Effect Of Hmgb1 On P. Gingivalis Induced Inflammatory Response By Macrophages, Michelle Marie Torres Santos
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BACKGROUND: Periodontitis is an inflammatory disease caused by poly-microbial infection that leads to destruction of connective tissue and alveolar bone. It is well documented that bacteria-derived virulent factors that can act on Toll-like receptors (TLRs), represented by Lipopolysaccharides (LPS), are engaged in the initiation of inflammatory responses. However, while LPS is also produced by the bacteria colonized in the healthy periodontal tissue, inflammation is not induced by LPS in those periodontal healthy subjects, suggesting the requirement of additional factor to upregulate the LPS-mediated inflammatory response in periodontal tissue. Recent studies revealed that novel class of endogenous proinflammatory mediator, high mobility …