Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Impacts Of Hydrophobic Mismatch On Antimicrobial Peptide Efficacy And Bilayer Permeabilization., Steven Meier, Zachary M Ridgway, Angela L Picciano, Gregory A. Caputo
Impacts Of Hydrophobic Mismatch On Antimicrobial Peptide Efficacy And Bilayer Permeabilization., Steven Meier, Zachary M Ridgway, Angela L Picciano, Gregory A. Caputo
Faculty Scholarship for the College of Science & Mathematics
Antimicrobial resistance continues to be a major threat to world health, with the continued emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an attractive option for the development of novel antimicrobial compounds in part due to their ubiquity in nature and the general lack of resistance development to this class of molecules. In this work, we analyzed the antimicrobial peptide C18G and several truncated forms for efficacy and the underlying mechanistic effects of the sequence truncation. The peptides were screened for antimicrobial efficacy against several standard laboratory strains, and further analyzed using fluorescence spectroscopy to evaluate binding to …
Characterization Of Gut Microbiome And Metabolome In Helicobacter Pylori Patients In An Underprivileged Community In The United States, Brian White, John D Sterrett, Zoya Grigoryan, Lauren Lally, Jared D Heinze, Hyder Alikhan, Christopher A Lowry, Lark Perez, Joshua Desipio, Sangita Phadtare
Characterization Of Gut Microbiome And Metabolome In Helicobacter Pylori Patients In An Underprivileged Community In The United States, Brian White, John D Sterrett, Zoya Grigoryan, Lauren Lally, Jared D Heinze, Hyder Alikhan, Christopher A Lowry, Lark Perez, Joshua Desipio, Sangita Phadtare
Faculty Scholarship for the College of Science & Mathematics
Background: Helicobacter pylori (H. pylori), a bacterium that infects approximately half of the world's population, is associated with various gastrointestinal diseases, including peptic ulcers, non-ulcer dyspepsia, gastric adenocarcinoma, and gastric lymphoma. As the burden of antibiotic resistance increases, the need for new adjunct therapies designed to facilitate H. pylori eradication and reduce negative distal outcomes associated with infection has become more pressing. Characterization of the interactions between H. pylori, the fecal microbiome, and fecal fatty acid metabolism, as well as the mechanisms underlying these interactions, may offer new therapeutic approaches. Aim: To characterize the gut microbiome and metabolome in H. …
Saliva Enhances Infection Of Gingival Fibroblasts By Herpes Simplex Virus 1., Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher
Saliva Enhances Infection Of Gingival Fibroblasts By Herpes Simplex Virus 1., Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher
Faculty Scholarship for the College of Science & Mathematics
Oral herpes is a highly prevalent infection caused by herpes simplex virus 1 (HSV-1). After an initial infection of the oral cavity, HSV-1 remains latent in sensory neurons of the trigeminal ganglia. Episodic reactivation of the virus leads to the formation of mucocutaneous lesions (cold sores), but asymptomatic reactivation accompanied by viral shedding is more frequent and allows virus spread to new hosts. HSV-1 DNA has been detected in many oral tissues. In particular, HSV-1 can be found in periodontal lesions and several studies associated its presence with more severe periodontitis pathologies. Since gingival fibroblasts may become exposed to salivary …
Interaction Between Nectin-1 And The Human Natural Killer Cell Receptor Cd96., Veronica M Holmes, Carlos Maluquer De Motes, Paige T Richards, Jessenia Roldan, Arjun K Bhargava, Jordan S Orange, Claude Krummenacher
Interaction Between Nectin-1 And The Human Natural Killer Cell Receptor Cd96., Veronica M Holmes, Carlos Maluquer De Motes, Paige T Richards, Jessenia Roldan, Arjun K Bhargava, Jordan S Orange, Claude Krummenacher
Faculty Scholarship for the College of Science & Mathematics
Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating and inhibitory signals acquired at the immunological synapse with potential target cells. NK cells express paired receptors from the immunoglobulin family which share common ligands from the nectin family of adhesion molecules. The activating receptor CD226 (DNAM-1) binds to nectin-2 and CD155, which are also recognized by the inhibitory receptor TIGIT. The third receptor in this family is CD96, which is less well characterized and may have different functions in human and mouse models. Human CD96 interacts with CD155 and ligation of this receptor activates …