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Tetr Family Regulator Brpt Modulates Biofilm Formation In Streptococcus Sanguinis, Jinlin Liu, Victoria N. Stone, Xiuchun Ge, Madison Tang, Fadi Elrami, Ping Xu

Microbiology and Immunology Publications

Biofilms are a key component in bacterial communities providing protection and contributing to infectious diseases. However, mechanisms involved in S. sanguinis biofilm formation have not been clearly elucidated. Here, we report the identification of a novel S. sanguinis TetR repressor, brpT (Biofilm Regulatory Protein TetR), involved in biofilm formation. Deletion of brpT resulted in a significant increase in biofilm formation. Interestingly, the mutant accumulated more water soluble and water insoluble glucans in its biofilm compared to the wild-type and the complemented mutant. The brpT mutation led to an altered biofilm morphology and structure exhibiting a rougher appearance, uneven …