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Mcp-1 Release Modulation Through Interaction Of Pulmonary Endothelial Cells And Mesenchymal Stromal Cells, Kaavya Giridhar
Mcp-1 Release Modulation Through Interaction Of Pulmonary Endothelial Cells And Mesenchymal Stromal Cells, Kaavya Giridhar
Dissertations & Theses (Open Access)
Background: Ischemic stroke is a leading cause of death and long-term disability
around the world. Current treatment options are limited to the administration of
tissue plasminogen activator (tPA) and/or endovascular therapy, administered within
a limited time window. However, cell-based therapies such as mesenchymal stromal
cells (MSCs) have increasingly shown great promise for ischemic stroke recovery
with some therapies already in various stages of clinical trials. Intravenous (IV)
administration of the MSCs leads to the entrapment of these MSCs in the lungs.
These entrapped MSCs interact with the pulmonary endothelial cells (PECs) and
could modulate the immune response through the release …
Modeling Post Stroke Respiratory Dysfunction, Apneas And Cognitive Decline, Anthony Patrizz
Modeling Post Stroke Respiratory Dysfunction, Apneas And Cognitive Decline, Anthony Patrizz
Dissertations & Theses (Open Access)
Modeling Post Stroke Respiratory Dysfunction,
Apneas and Cognitive Decline
Anthony Patrizz, B.A.
Advisory Professor: Louise McCullough M.D., Ph.D.
Stroke is a major cause of mortality and the leading cause of long-term disability in the US. More than 60% of individuals suffering a first time stroke develop respiratory dysfunction, prolonging recovery and increasing mortality. Post-stroke cognitive decline is a major contributor to disability and nursing home placement, therefore the cognitive consequences of Stroke Induced Respiratory Dysfunction (SIRD) need to be explored if we hope to enhance functional recovery. The first step towards treatment of the negative consequences of SIRD is the …