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Quantitative Imaging For Precision Medicine In Head And Neck Cancer Patients, Rachel Ger
Quantitative Imaging For Precision Medicine In Head And Neck Cancer Patients, Rachel Ger
Dissertations & Theses (Open Access)
The purpose of this work was to determine if prediction models using quantitative imaging measures in head and neck squamous cell carcinoma (HNSCC) patients could be improved when noise due to imaging was reduced. This was investigated separately for salivary gland function using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), overall survival using computed tomography (CT)-based radiomics, and overall survival using positron emission tomography (PET)-based radiomics. From DCE-MRI, where T1-weighted images are serially acquired after injection of contrast, quantitative measures of diffusion can be obtained from the series of images. Radiomics is the study of the relationship of voxels to …
Reduction Of Dose Calculation Errors For Patients With Metal Implants Receiving Photon Radiation Therapy, Jessie Huang-Vredevoogd
Reduction Of Dose Calculation Errors For Patients With Metal Implants Receiving Photon Radiation Therapy, Jessie Huang-Vredevoogd
Dissertations & Theses (Open Access)
Many patients receiving external beam radiation therapy have metal implants that can affect their treatment, and these metal implants can degrade the accuracy of dose calculations. Dose calculation errors result from limitations of modern dose calculation algorithms in modeling metal/tissue interface effects. Metals also cause streak artifacts in the computed tomography (CT) images that are used for treatment planning, and these artifacts can also degrade dose calculation accuracy. Metal based-energy deposition kernels are a potential solution for the calculation errors associated with the limitations of the convolution/superposition (C/S) dose calculation method as they better model photon interactions and scatter in …