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Alternative Carbon Utilization As A Virulence Determinant For Candida Albicans, Robert Williams
Alternative Carbon Utilization As A Virulence Determinant For Candida Albicans, Robert Williams
Dissertations & Theses (Open Access)
Candida albicans is a polymorphic unicellular fungus that has evolved to proficiently colonize and infect mammals. A common constituent of the microbiome in the GI tract, mouth, vagina, and skin, C. albicans is also an opportunistic pathogen capable of causing a variety of mucosal infections and the life-threatening disseminated candidiasis. Systemic C. albicans infections are a serious and growing issue; the fungus is the fourth most common cause of nosocomial bloodstream infections which has a mortality rate reaching 50%. As antifungal resistance continues to rise, it is critical that I understand the molecular basis of disseminated fungal infections.
The phagocytes …