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Enzymatic Pathways Of The Brain Renin-Angiotensin System: Unsolved Problems And Continuing Challenges, Vardan T. Karamyan, Robert C. Speth
Enzymatic Pathways Of The Brain Renin-Angiotensin System: Unsolved Problems And Continuing Challenges, Vardan T. Karamyan, Robert C. Speth
HPD Articles
The brain renin-angiotensin system continues to be enigmatic more than 40 years after the brain was first recognized to be a site of action of angiotensin II. This review focuses on the enzymatic pathways for the formation and degradation of the growing number of active angiotensins in the brain. A brief description and nomenclature of the peptidases involved in the processing of angiotensin peptides in the brain is given. Of primary interest is the array of enzymes that degrade radiolabeled angiotensins in receptor binding assays. This poses major challenges to studies of brain angiotensin receptors and it is debatable whether …
Placental Insufficiency Results In Temporal Alterations In The Renin Angiotensin System In Male Hypertensive Growth Restricted Offspring, Daniela Grigore, Norma B. Ojeda, Elliot B. Robertson, Antoinette S. Dawson, Contrina A. Huffman, Erick A. Bourassa, Robert C. Speth, K Bridget Brosnihan, Barbara T. Alexander
Placental Insufficiency Results In Temporal Alterations In The Renin Angiotensin System In Male Hypertensive Growth Restricted Offspring, Daniela Grigore, Norma B. Ojeda, Elliot B. Robertson, Antoinette S. Dawson, Contrina A. Huffman, Erick A. Bourassa, Robert C. Speth, K Bridget Brosnihan, Barbara T. Alexander
HPD Articles
Reduced uterine perfusion initiated in late gestation in the rat results in intrauterine growth restriction (IUGR) and development of hypertension by 4 wk of age. We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long-term control of blood pressure, may be programmed by placental insufficiency and may contribute to the etiology of IUGR hypertension. We previously reported that RAS blockade abolished hypertension in adult IUGR offspring; however, the mechanisms responsible for the early phase of hypertension are unresolved. Therefore, the purpose of this study was to examine RAS involvement in early programmed hypertension and to …
Regulatory Polymorphisms In The Cyclophilin A Gene, Ppia, Accelerate Progression To Aids, Ping An, Li Hua Wang, Holli Hutcheson-Dilks, George Nelson, Sharyne Donfield, James J. Goedert, Charles Rinaldo, Susan Buchbinder, Gregory D. Kirk, Stephen J. O'Brien, Cheryl Winkler
Regulatory Polymorphisms In The Cyclophilin A Gene, Ppia, Accelerate Progression To Aids, Ping An, Li Hua Wang, Holli Hutcheson-Dilks, George Nelson, Sharyne Donfield, James J. Goedert, Charles Rinaldo, Susan Buchbinder, Gregory D. Kirk, Stephen J. O'Brien, Cheryl Winkler
Biology Faculty Articles
Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus uncoating. We examined the effect of single nucleotide polymorphisms (SNPs) and haplotypes within the PPIA gene on HIV-1 infection and disease progression in five HIV-1 longitudinal history cohorts. Kaplan-Meier survival statistics and Cox proportional hazards model were used to assess time to AIDS outcomes. Among eight SNPs tested, two promoter SNPs (SNP3 and SNP4) in perfect linkage disequilibrium were associated with more rapid CD4+ T-cell loss (relative hazard = …
Prevention Of Angiotensin Ii-Induced Cardiac Remodeling By Angiotensin-(1-7), Justin L. Grobe, Adam P. Mecca, Melissa Lingis, Vinayak Shenoy, Tonya A. Bolton, Juline M. Machado, Robert C. Speth, Mohan K. Raizada, Michael J. Katovich
Prevention Of Angiotensin Ii-Induced Cardiac Remodeling By Angiotensin-(1-7), Justin L. Grobe, Adam P. Mecca, Melissa Lingis, Vinayak Shenoy, Tonya A. Bolton, Juline M. Machado, Robert C. Speth, Mohan K. Raizada, Michael J. Katovich
HPD Articles
Cardiac remodeling, which typically results from chronic hypertension or following an acute myocardial infarction, is a major risk factor for the development of heart failure and, ultimately, death. The renin-angiotensin system (RAS) has previously been established to play an important role in the progression of cardiac remodeling, and inhibition of a hyperactive RAS provides protection from cardiac remodeling and subsequent heart failure. Our previous studies have demonstrated that overexpression of angiotensin-converting enzyme 2 (ACE2) prevents cardiac remodeling and hypertrophy during chronic infusion of angiotensin II (ANG II). This, coupled with the knowledge that ACE2 is a key enzyme in the …
Genetic Protection Against Hepatitis B Virus Conferred By Ccr5Δ32: Evidence That Ccr5 Contributes To Viral Persistence, Chloe L. Thio, Jacquie Astemborski, Arman A. Bashirova, Timothy L. Mosbruger, Spencer Greer, Mallory D. Witt, James J. Goedert, Margaret Hilgartner, Audrey Majesk, Stephen J. O'Brien, David L. Thomas, Mary Carrington
Genetic Protection Against Hepatitis B Virus Conferred By Ccr5Δ32: Evidence That Ccr5 Contributes To Viral Persistence, Chloe L. Thio, Jacquie Astemborski, Arman A. Bashirova, Timothy L. Mosbruger, Spencer Greer, Mallory D. Witt, James J. Goedert, Margaret Hilgartner, Audrey Majesk, Stephen J. O'Brien, David L. Thomas, Mary Carrington
Biology Faculty Articles
Recovery from acute hepatitis B virus (HBV) infection requires a broad, vigorous T-cell response, which is enhanced in mice when chemokine receptor 5 (CCR5) is missing. To test the hypothesis that production of a nonfunctional CCR5 (CCR5Δ32 [a functionally null allele containing a 32-bp deletion]) increases the likelihood of recovery from hepatitis B in humans, we studied 526 persons from three cohorts in which one person with HBV persistence was matched to two persons who recovered from an HBV infection. Recovery or persistence was determined prior to availability of lamivudine. We determined genotypes forCCR5Δ32 …
Polymorphisms Of Cul5 Are Associated With Cd4+ T Cell Loss In Hiv-1 Infected Individuals, Ping An, Priya Duggal, Li Hua Wang, Stephen J. O'Brien, Sharyne Donfield, James J. Goedert, John Phair, Susan Buchbinder, Gregory D. Kirk, Cheryl Winkler
Polymorphisms Of Cul5 Are Associated With Cd4+ T Cell Loss In Hiv-1 Infected Individuals, Ping An, Priya Duggal, Li Hua Wang, Stephen J. O'Brien, Sharyne Donfield, James J. Goedert, John Phair, Susan Buchbinder, Gregory D. Kirk, Cheryl Winkler
Biology Faculty Articles
Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1. However, HIV-1 viral infectivity factor (Vif) suppresses Apobec3 activity through the Cullin 5-Elongin B-Elongin C E3 ubiquitin ligase complex. We examined the effect of genetic polymorphisms in the CUL5 gene (encoding Cullin 5 protein) on AIDS disease progression in five HIV-1 longitudinal cohorts. A total of 12 single nucleotide polymorphisms (SNPs) spanning 93 kb in the CUL5 locus were genotyped and their haplotypes inferred. A phylogenetic network analysis revealed that CUL5 haplotypes were grouped into two clusters …
International Society Of Sports Nutrition Position Stand: Protein And Exercise., B. Campbell, R. B. Kreider, T. Ziegenfuss, P. La Bounty, M. Roberts, D. Burke, J. Landis, H. Lopez, Jose Antonio
International Society Of Sports Nutrition Position Stand: Protein And Exercise., B. Campbell, R. B. Kreider, T. Ziegenfuss, P. La Bounty, M. Roberts, D. Burke, J. Landis, H. Lopez, Jose Antonio
Department of Health and Human Performance Faculty Articles
The following seven points related to the intake of protein for healthy, exercising individuals constitute the position stand of the Society. They have been approved by the Research Committee of the Society. 1) Vast research supports the contention that individuals engaged in regular exercise training require more dietary protein than sedentary individuals. 2) Protein intakes of 1.4 – 2.0 g/kg/day for physically active individuals is not only safe, but may improve the training adaptations to exercise training. 3) When part of a balanced, nutrient-dense diet, protein intakes at this level are not detrimental to kidney function or bone metabolism in …
International Society Of Sports Nutrition Position Stand: Creatine Supplementation And Exercise., T. W. Buford, R. B. Kreider, J. R. Stout, M. Greenwood, B. Campbell, M. Spano, T. Ziegenfuss, H. Lopez, J. Landis, Jose Antonio
International Society Of Sports Nutrition Position Stand: Creatine Supplementation And Exercise., T. W. Buford, R. B. Kreider, J. R. Stout, M. Greenwood, B. Campbell, M. Spano, T. Ziegenfuss, H. Lopez, J. Landis, Jose Antonio
Department of Health and Human Performance Faculty Articles
No abstract provided.
College Of Osteopathic Medicine Syllabus, Nova Southeastern University
College Of Osteopathic Medicine Syllabus, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Health Professions Division Catalog 2007-2008, Nova Southeastern University
Health Professions Division Catalog 2007-2008, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Masters Of Public Health 2007, Nova Southeastern University
Masters Of Public Health 2007, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Academic Review Reports, Health Science, D.H.S. 2007-2008, Nova Southeastern University
Academic Review Reports, Health Science, D.H.S. 2007-2008, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
College Of Dental Medicine Student Handbook 2007-2008, Nova Southeastern University
College Of Dental Medicine Student Handbook 2007-2008, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
College Of Osteopathic Medicine 2007, Nova Southeastern University
College Of Osteopathic Medicine 2007, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Health Professions Division Testing Center Handbook, Nova Southeastern University
Health Professions Division Testing Center Handbook, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
College Of Allied Health And Nursing Student Handbook 2007-2008, Nova Southeastern University
College Of Allied Health And Nursing Student Handbook 2007-2008, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
College Of Dental Medicine 2007, Nova Southeastern University
College Of Dental Medicine 2007, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.