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Evaluation Of A ‘Well-Elderly’ Physical Activity Programme, Robert Purcell
Evaluation Of A ‘Well-Elderly’ Physical Activity Programme, Robert Purcell
Theses
Both in Ireland and internationally people are living longer and there is an increasing proportion of older adults in the population (Clark 2020). As such, the maintenance of health and physical function for older adults is of critical importance. Physical activity is widely acknowledged as being crucial for the maintenance of positive health, particularly for older adults (Spartano et al., 2019). Research has suggested that physical activity programmes are an effective means of engaging older adults in physical activity for the promotion of positive health (Sherrington et al., 2017). The central aim of this research project was to explore the …
Defining The Potential Of Gene Therapy With Bone Morphogenetic Proteins As A Novel Therapeutic Approach In Parkinson’S Disease, Susan Rebecca Goulding
Defining The Potential Of Gene Therapy With Bone Morphogenetic Proteins As A Novel Therapeutic Approach In Parkinson’S Disease, Susan Rebecca Goulding
Theses
Parkinson’s disease is a neurodegenerative disorder, characterised by the progressive degeneration of midbrain dopaminergic neurons, and the intracellular aggregation of the α-synuclein protein in neurons throughout the nervous system. These changes result in the characteristic motor impairments in Parkinson’s disease. Current treatments are solely symptomatic and therefore there is an unmet clinical need to develop new disease-modifying therapies that can alter disease progression. For over 25 years, one proposed experimental therapy has focused on the delivery of proteins called neurotrophic factors to the brain to prevent dopaminergic neuron degeneration. However, to date, clinical trials using the most well-known neurotrophic factors …