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Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Pathology Associated With Aav Mediated Expression Of Beta Amyloid Or C100 In Adult Mouse Hippocampus And Cerebellum, Eleanor S. Drummond, Jill Muhling, Ralph Martins, Linda K. Wijaya, Erich M. Ehlert, Alan R. Harvey
Pathology Associated With Aav Mediated Expression Of Beta Amyloid Or C100 In Adult Mouse Hippocampus And Cerebellum, Eleanor S. Drummond, Jill Muhling, Ralph Martins, Linda K. Wijaya, Erich M. Ehlert, Alan R. Harvey
Research outputs 2013
Accumulation of beta amyloid (Ab) in the brain is a primary feature of Alzheimer’s disease (AD) but the exact molecular mechanisms by which Ab exerts its toxic actions are not yet entirely clear. We documented pathological changes 3 and 6 months after localised injection of recombinant, bi-cistronic adeno-associated viral vectors (rAAV2) expressing human Ab40- GFP, Ab42-GFP, C100-GFP or C100V717F-GFP into the hippocampus and cerebellum of 8 week old male mice. Injection of all rAAV2 vectors resulted in wide-spread transduction within the hippocampus and cerebellum, as shown by expression of transgene mRNA and GFP protein. Despite the lack of accumulation of …
Brief Oral Health Promotion Intervention Among Parents Of Young Children To Reduce Early Childhood Dental Decay, Peter Arrow, Joseph Raheb, Margaret Miller
Brief Oral Health Promotion Intervention Among Parents Of Young Children To Reduce Early Childhood Dental Decay, Peter Arrow, Joseph Raheb, Margaret Miller
Research outputs 2013
Background: Severe untreated dental decay affects a child's growth, body weight, quality of life as well as cognitive development, and the effects extend beyond the child to the family, the community and the health care system. Early health behavioural factors, including dietary practices and eating patterns, can play a major role in the initiation and development of oral diseases, particularly dental caries. The parent/caregiver, usually the mother, has a critical role in the adoption of protective health care behaviours and parental feeding practices strongly influence children's eating behaviours. This study will test if an early oral health promotion intervention through …
Mining Workers Ability To Identify Hazards Using A Picture Survey, Susanne T. Bahn
Mining Workers Ability To Identify Hazards Using A Picture Survey, Susanne T. Bahn
Research outputs 2013
This paper presents the first phase on a study investigating the skills of workers in the resource sector at their safety induction to identify workplace hazards. This study questioned the ability of managers and employees to identify workplace hazards correctly (phase 1) and to determine the processes that can be used to increase hazard identification skills (phase 2). Fifty-four completed surveys that contained 6 pictures displaying complex and hazardous work environments in an underground mine in WA are analysed. The analysis sought to determine the average number of hazards that each participant could identify out of a possible 10 in …
High-Frequency Stimulation Of Nucleus Accumbens Changes In Dopaminergic Reward Circuit, Na Yan, Ning Chen, Honghua Zhu, Jianguo Zhang, Moira Sim, Yu Ma, Wei Wang
High-Frequency Stimulation Of Nucleus Accumbens Changes In Dopaminergic Reward Circuit, Na Yan, Ning Chen, Honghua Zhu, Jianguo Zhang, Moira Sim, Yu Ma, Wei Wang
Research outputs 2013
Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is a potential remedial therapy for drug craving and relapse, but the mechanism is poorly understood. We investigated changes in neurotransmitter levels during high frequency stimulation (HFS) of the unilateral NAc on morphine-induced rats. Sixty adult Wistar rats were randomized into five groups: the control group (administration of saline), the morphine-only group (systematic administration of morphine without electrode implantation), the morphine-sham-stimulation group (systematic administration of morphine with electrode implantation but not given stimulation), the morphine-stimulation group (systematic administration of morphine with electrode implantation and stimulation) and the saline-stimulation group (administration of …