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Articles 1 - 4 of 4
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“Provoking Conversations”: Case Studies Of Organizations Where Option Grid™ Decision Aids Have Become ‘Normalized’, Peter Scalia, Glyn Elwyn, Marie-Anne Durand
“Provoking Conversations”: Case Studies Of Organizations Where Option Grid™ Decision Aids Have Become ‘Normalized’, Peter Scalia, Glyn Elwyn, Marie-Anne Durand
Dartmouth Scholarship
Background: Implementing patient decision aids in clinic workflow has proven to be a challenge for healthcare organizations and physicians. Our aim was to determine the organizational strategies, motivations, and facilitating factors to the routine implementation of Option Grid™ encounter decision aids at two independent settings. Method: Case studies conducted by semi-structured interview, using the Normalization Process Theory (NPT) as a framework for thematic analysis. Twenty three interviews with physicians, nurses, hospital staff and stakeholderswere conducted at: 1) CapitalCare Medical Group in Albany, New York; 2) HealthPartners Clinics in Minneapolis, Minnesota. Results: ‘Coherent’ motivations were guided by financial incentives at CapitalCare, …
Tenofovir Inhibits Wound Healing Of Epithelial Cells And Fibroblasts From The Upper And Lower Human Female Reproductive Tract, Marta Rodriguez-Garcia, Mickey V. Patel, Zheng Shen, Jack Bodwell, Richard M. Rossol, Charles R. Wira
Tenofovir Inhibits Wound Healing Of Epithelial Cells And Fibroblasts From The Upper And Lower Human Female Reproductive Tract, Marta Rodriguez-Garcia, Mickey V. Patel, Zheng Shen, Jack Bodwell, Richard M. Rossol, Charles R. Wira
Dartmouth Scholarship
Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV-target cell recruitment. Here we determined whether Tenofovir (TFV), used vaginally in HIV prevention trials, and Tenofovir alafenamide (TAF), an improved prodrug of TFV, interfere with wound healing in the human FRT. TFV treatment of primary epithelial cells and fibroblasts from the endometrium (EM), endocervix (CX) and ectocervix (ECX) significantly delayed wound closure. Reestablishment of tight junctions was compromised in EM and CX epithelial cells even after wound closure occurred. In contrast, TAF had no inhibitory …
Mitogen-Activated Protein Kinase Phosphatase-3 (Mkp-3) In The Surgical Wound Is Necessary For The Resolution Of Postoperative Pain In Mice, Sladjana Skopelja-Gardner, Madhurima Saha, Perla Abigail Alvarado-Vazquez, Brenna S. Liponis, Elena Martinez, E Alfonso Romero-Sandoval
Mitogen-Activated Protein Kinase Phosphatase-3 (Mkp-3) In The Surgical Wound Is Necessary For The Resolution Of Postoperative Pain In Mice, Sladjana Skopelja-Gardner, Madhurima Saha, Perla Abigail Alvarado-Vazquez, Brenna S. Liponis, Elena Martinez, E Alfonso Romero-Sandoval
Dartmouth Scholarship
Mitogen-activated protein kinase (MAPK) phosphatase-3 (MKP-3) and its substrates (extracellular signal-regulated kinase [ERK] and p38) play an important role in pathophysiological mechanisms of acute postoperative and chronic neuropathic pain in the spinal cord. This study aimed to understand the role of MKP-3 and its target MAPKs at the site of surgical incision in nociceptive behavior. Wild-type (WT) and MKP-3 knockout (KO) mice underwent unilateral plantar hind paw incision. Mechanical allodynia was assessed by using von Frey filaments. Peripheral ERK-1/2 and p38 phosphorylation were measured by Western blot. Cell infiltration was determined using hematoxylin and eosin histological staining. Peripheral phosphorylated ERK-1/2 …
Association Of Igg4 Response And Autoimmune Pancreatitis With Intraductal Papillary-Mucinous Neoplasms, Amin A. Hedayat, Mikhail Lisovsky, Arief A. Suriawinata
Association Of Igg4 Response And Autoimmune Pancreatitis With Intraductal Papillary-Mucinous Neoplasms, Amin A. Hedayat, Mikhail Lisovsky, Arief A. Suriawinata
Dartmouth Scholarship
Objectives: Concurrent intraductal papillary-mucinous neoplasm (IPMN) and autoimmune pancreatitis (AIP) was observed in a patient (index case) at our institution. Cases of coincidental IPMN and type 1 AIP and concurrent ductal adenocarcinoma (PDAC) and AIP have been previously reported. In this study we evaluate the hypothesis that IPMN elicits an IgG4 response. Methods: Twenty-one pancreases (including the index case) with IPMN resected at our institution were studied. H&E stained slides were reviewed and blocks of peritumoral pancreas were immunostained with IgG4 to look for IgG4-positive plasma cells. Results: We found evidence of variable IgG4 overexpression in 4/21 (19%) of IPMN. …