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Articles 1 - 30 of 35210
Full-Text Articles in Entire DC Network
Adjudicating Technology Facilitated Violence Against Women In Egypt: Between The Text And The Application, Eman E. Zidan
Adjudicating Technology Facilitated Violence Against Women In Egypt: Between The Text And The Application, Eman E. Zidan
Theses and Dissertations
Technology-facilitated violence against women (TFVAW) has surged on digital platforms, leading to a sharp rise in victimization rates among girls and women globally. Egypt’s pioneering cybercrime legislation, though comprehensive, remains gender-neutral and inadequate in judicial application. Community perceptions reveal systemic gaps that erode public trust and fuel demands for specialized protections. This study analyzes Egyptian judicial responses to TFVAW cases through comparative jurisprudence with jurisdictions that feature gender-specific norms. Findings demonstrate that textual provisions alone fail to arrest this escalating phenomenon, underscoring the need for integrated reforms: tailored legislation, heightened awareness campaigns, and collaborative education on rights, duties, and societal …
Endogenous Light In The Brain: Investigating Sources, Propagation, And State-Dependent Emission, Emre Cicek
Endogenous Light In The Brain: Investigating Sources, Propagation, And State-Dependent Emission, Emre Cicek
Theses and Dissertations (Comprehensive)
Ultraweak photon emission (UPE), and by extension light, has long been thought to be a modality of communication in nature. Prior studies have already identified that UPE can depend on cell type and can be used to discern between malignant and benign cells. However, besides theoretical models, not much effort has been made to identify possible biological structures that would allow for light to be used as a method of communication in the human body. According to the framework set by Shannon’s Information Theory, for communication to be possible at minimum a transmitter, a transmission channel, and a receiver are …
Sar Ship Detection Based On Shallow Feature Guidance, Chenxu Xia, Peng Chen, Ya Zhang, Ying Li
Sar Ship Detection Based On Shallow Feature Guidance, Chenxu Xia, Peng Chen, Ya Zhang, Ying Li
Journal of Marine Science and Technology–Taiwan
Maritime ship detection is of great significance for both military security and civilian applications. Synthetic Aperture Radar (SAR), with its all-weather and all-day imaging capability, plays a vital role in maritime surveillance. Nevertheless, SAR ship targets typically appear small in scale, embedded in complex backgrounds, blurred at boundaries, and easily confused with near-shore features, which pose substantial challenges for accurate detection. To address these issues, we propose a SAR ship detection network that integrates dual enhancements of small-object representation and edge information. The network introduces two key components: the Small Target Refine Pyramid (STRP) to strengthen shallow feature representation for …
Investigating The Ability Of Presequences To Influence Mitochondrial Protein Import, Youmian Yan
Investigating The Ability Of Presequences To Influence Mitochondrial Protein Import, Youmian Yan
WUSM Theses and Dissertations – All Programs
Mitochondria are essential organelles housing over 1000 proteins, 99% of which are nuclear-encoded and synthesized in the cytosol. Most mitochondrial proteins are targeted by a positively charged sequence called the presequence, which lacks a common sequence motif and is poorly conserved across evolution. Accumulating evidence suggests that presequences encode meaningful information that influences mitochondrial protein uptake. For instance, multiple stress response models propose that stress sensing proteins contain “weak” presequences which allows them to monitor mitochondrial health. However, there is a lack of systematic examination about how presequences influence import kinetics and what constitutes presequence strength. These gaps in knowledge …
Balancing Root-Zone Oxygenation And Rhizosphere Stability: The Impact Of Aeration And Hypoxia On Hydroponic Plant Growth, Christian D. Baker
Balancing Root-Zone Oxygenation And Rhizosphere Stability: The Impact Of Aeration And Hypoxia On Hydroponic Plant Growth, Christian D. Baker
All Graduate Theses and Dissertations, Fall 2023 to Present
As the global population and food demand continue to increase, growers must look to innovative and sustainable methods for plant cultivation. Hydroponics is a popular method of sustainable plant cultivation where plant roots are suspended over a liquid nutrient solution. Hydroponics uses less water compared to traditional agriculture because there is no evaporation or solution runoff. It also maximizes land use, requires fewer pesticides and herbicides, and enables year-round cultivation in controlled environments. However, indoor hydroponic systems rely on artificial lighting, which has higher energy costs than traditional farming methods. Optimizing growing conditions is therefore critical to ensure long-term economic …
The Willing And The Compelled: How Power And Place Shape Human-Bison Coexistence In Poland And The United States, Patrick Orville Kelly
The Willing And The Compelled: How Power And Place Shape Human-Bison Coexistence In Poland And The United States, Patrick Orville Kelly
All Graduate Theses and Dissertations, Fall 2023 to Present
Wildlife recovery programs depend not just on animals, but on how people feel about living with them. The degree to which people accept the disruptions wildlife brings to their lives, known as social tolerance, can determine whether a recovery program succeeds or fails, yet it remains understudied and underapplied in management plans. This dissertation studies how people in Poland and the western United States feel about living with the two living species of bison, the largest land animals in Europe and North America. In Poland, we surveyed 242 residents living at different distances from European bison habitat. Surprisingly, the most …
Harnessing Digital Twin (Dt) Technology For Food Security And Climate Resilience In Sub-Saharan Africa (Ssa), Henri E.Z. Tonnang, Francis Chianu, Siyabusa Mkuhlani, Francis Muthoni, John Michael Humphries Choptiany, Franck B.N. Tonle, Bonoukpoe M. Sokame, Mercy Lung’Aho
Harnessing Digital Twin (Dt) Technology For Food Security And Climate Resilience In Sub-Saharan Africa (Ssa), Henri E.Z. Tonnang, Francis Chianu, Siyabusa Mkuhlani, Francis Muthoni, John Michael Humphries Choptiany, Franck B.N. Tonle, Bonoukpoe M. Sokame, Mercy Lung’Aho
All Peer-Reviewed Publications
Sub-Saharan Africa (SSA) faces chronic food insecurity despite possessing approximately 60% of the world’s uncultivated arable land. Field trials generate evidence but are costly and insufficiently scaled to address accelerating climate and demographic pressures. Digital twin (DT) technology, defined as the continuous, bidirectional virtual replication of physical systems using real-time data, supports monitoring, modelling, and optimisation of agrifood systems. To our knowledge, however, no published synthesis has examined DT agriculture research through the lens of SSA food systems or smallholder farming realities. A PRISMA-compliant systematic review was conducted across bibliographic databases using a pre-defined Boolean search and adapted PICOS eligibility …
Associations Of Subclinical Hypothyroidism And Thyroid Autoimmunity With Insulin Resistance Independent Of Adiposity: An Analysis Of Nhanes, Iman Taher Hussein
Associations Of Subclinical Hypothyroidism And Thyroid Autoimmunity With Insulin Resistance Independent Of Adiposity: An Analysis Of Nhanes, Iman Taher Hussein
AUIQ Complementary Biological System
A thyroid–inflammation–insulin pathway has been proposed in which thyroid dysfunction promotes inflammation and thereby reduces insulin sensitivity, but adiposity-adjusted population evidence is limited. This cross-sectional analysis examined whether subclinical hypothyroidism (SCH) and thyroid autoimmunity are associated with insulin resistance independently of body mass index (BMI), and whether C-reactive protein (CRP), the only inflammatory biomarker available, is associated with either, using National Health and Nutrition Examination Survey (NHANES) 2007–2012 data. Non-pregnant adults aged 18–60 years with fasting glucose < 126 mg/dL and normal free thyroxine were included; SCH was defined as thyroid-stimulating hormone (TSH) 4.5–10 mIU/L, and insulin resistance was quantified by the homeostasis model assessment (HOMA-IR). Linear regression of log HOMA-IR accounted for the complex survey design (strata, clusters, weights) and was adjusted for age, sex, BMI, and survey cycle, with sensitivity and interaction analyses. Among 2,434 adults (89 with SCH), no association with HOMA-IR was detected for TSH (β = 0.009 per mIU/L; 95% CI -0.014 to 0.032), SCH (β = -0.035; 95% CI -0.186 to 0.115), or thyroid peroxidase …
Nanoparticle-Based Innovations In Lung Cancer Treatment: Challenges And Opportunities, Shailesh Sharma, Chamanpreet Kaur, Gurminder Kaur, Surajpal Verma
Nanoparticle-Based Innovations In Lung Cancer Treatment: Challenges And Opportunities, Shailesh Sharma, Chamanpreet Kaur, Gurminder Kaur, Surajpal Verma
Journal of Food and Drug Analysis
Nanoparticles (NPs) present a therapeutic revolution in the context of lung cancer, having several and unique advantages over many traditional drugs, such as increased specificity, minimal side effects on healthy tissues, and increased efficacy. It definitely provides a detailed understanding of preparation techniques for nanoparticles for lung cancer treatment, as well as assessment approaches and therapeutic applications of nanoparticles in cancer treatment. The incorporation of drugs into nanoparticle-based systems is then critically discussed with emphasis on their capability to circumvent MDR and target tumour cell lines. Also, the review mentioned the development in the agnostic application, the nanoparticles that are …
A Lightweight Multitask Adaptive Fusion Network With Channel Attention For Uav-Based Crop Detection And Classification, Xuanyu Yue, Zhenyu Wan
A Lightweight Multitask Adaptive Fusion Network With Channel Attention For Uav-Based Crop Detection And Classification, Xuanyu Yue, Zhenyu Wan
Turkish Journal of Agriculture and Forestry
Unmanned aerial vehicles (UAVs) have become essential tools in precision agriculture, facilitating large-scale monitoring of crop health, weed proliferation, and overall field conditions. However, conventional single-task recognition models encounter significant challenges when implemented on resource-constrained UAV platforms, particularly in detecting densely distributed small objects, managing scale variations, and addressing occlusions. To address these challenges, this paper proposes a channel attention-based adaptive fusion network (CNAF-Net) specifically designed for agricultural scenarios. CNAF-Net utilizes MobileNetV3 for hierarchical feature extraction and integrates a channel attention-guided adaptive fusion mechanism that dynamically combines multiscale features across detection, classification, and segmentation tasks. Experiments conducted on the WeedMap …
The Collagen-Derived Tripeptide Gly-Pro-Hyp Suppresses Fgf-5 Expression And Promotes Anagen Induction In C3h/Hej Mice, Yun-Ho Kim, Jin Seok Kim, Woong Yong Kim, Hyun Jung Jo, Zhe Piao, Yeo Cho Yoon
The Collagen-Derived Tripeptide Gly-Pro-Hyp Suppresses Fgf-5 Expression And Promotes Anagen Induction In C3h/Hej Mice, Yun-Ho Kim, Jin Seok Kim, Woong Yong Kim, Hyun Jung Jo, Zhe Piao, Yeo Cho Yoon
Turkish Journal of Biology
Background/aim: Collagen-derived peptides have shown potential in promoting hair growth, yet their effects on catagen-inducing factors remain unexplored. In this study, the hair growth-promoting effects and molecular mechanisms of Collagen-Tripep20 (CTP), a collagen tripeptide preparation containing 3.2% Gly-Pro-Hyp (GPH), were explored, with a specific focus on fibroblast growth factor 5 (FGF-5) regulation.
Materials and methods: Female C3H/HeJ mice were randomly assigned to four groups (n = 10/group): control, CTP-LOW (400 mg/ kg/day), CTP-HIGH (800 mg/kg/day), and GPH (25.6 mg/kg/day). Following dorsal depilation, test substances were administered dailyvia oral gavage for 7 weeks. Hair regrowth was assessed by visual scoring, histological …
Understanding Antimicrobial Peptide Activation In Mesenchymal Stem Cells Through The Aryl Hydrocarbon Receptor Pathway And Inflammatory Signals, Cansu Özdemi̇r Saka, Beyza Turgut, Ceren Tuncay, Cemi̇l Can Eylem, Emi̇rhan Nemutlu
Understanding Antimicrobial Peptide Activation In Mesenchymal Stem Cells Through The Aryl Hydrocarbon Receptor Pathway And Inflammatory Signals, Cansu Özdemi̇r Saka, Beyza Turgut, Ceren Tuncay, Cemi̇l Can Eylem, Emi̇rhan Nemutlu
Turkish Journal of Biology
Background/aim: Antimicrobial peptides (AMPs) are small peptides involved in host defense and have been widely studied for their roles in innate immunity against microbial pathogens. Mesenchymal stem cells (MSCs), which provide stromal support in tissues such as bone marrow, are also capable of secreting AMPs, although the signaling pathways controlling this function remain unclear. The present study investigates the role of the aryl hydrocarbon receptor (AHR) signaling, a xenobiotic response pathway, in AMP production by MSCs.
Materials and methods: To assess AMP activation, human MSCs were stimulated with the agonist FICZ and antagonist SR1. TNF-α + IL-1β and LPS were …
Pgcc-Derived Daughter Cells Are Associated With Aggressive Phenotypes In Gastric Cancer, Özlem Türksoy Terzi̇oğlu
Pgcc-Derived Daughter Cells Are Associated With Aggressive Phenotypes In Gastric Cancer, Özlem Türksoy Terzi̇oğlu
Turkish Journal of Biology
Background/aim: Polyploid giant cancer cells (PGCCs) have been implicated in tumor recurrence, therapeutic resistance, and cellular plasticity; however, the biological properties of PGCC-derived daughter cells (PGCC-DCs) in gastric cancer remain poorly understood. The present study aimed to evaluate the molecular and functional characteristics of these progeny cells in a gastric cancer model.
Methods: The PGCCs were induced in HGC-27 gastric cancer cells using cobalt(II) chlorideCoCl2-mediated hypoxic stress and enriched by size-based filtration. The PGCC-DCs were isolated through single-cell culture and characterized using molecular and functional assays. Clinical assessments of the cellular parameters were conducted by comparing the PGCC-DCs with parental …
Astaxanthin Elicits A Shared Transcriptional Core And Divergent Cell-Type-Specific Responses In Mcf-7 Breast And Ovcar-3 Ovarian Carcinoma Cells, Duygu Aygüneş Jafari
Astaxanthin Elicits A Shared Transcriptional Core And Divergent Cell-Type-Specific Responses In Mcf-7 Breast And Ovcar-3 Ovarian Carcinoma Cells, Duygu Aygüneş Jafari
Turkish Journal of Biology
Background/aim: Astaxanthin, a marine carotenoid, shows antiproliferative activity across cancer models, but its reported mechanisms vary widely by cell type and comparative studies with a common protocol are scarce. This study compared MCF-7 breast (estrogen/ progesterone receptor-positive; wild-type TP53) and OVCAR-3 ovarian carcinoma (high-grade serous; homozygous TP53 R248Q) cells after astaxanthin treatment at cell-line-specific IC50 concentrations.
Materials and methods: Cytotoxicity was measured by WST-1, apoptosis by annexin V/propidium iodide flow cytometry, and 43 cancer-associated genes by a pathway-focused RT-qPCR array (n = 3). Relative expression was calculated by comparative ΔΔCt method with ACTB as the reference gene.
Results: At 72 …
Tuber Yield Amplification In Dahlia Variabilis L. Under Humic Acid And Fertilizer Combinations, Kedar Mahadev Gheware, Nomita Laishram, Arvinder Singh, Sarabdeep Kour, Sourav Sharma, Aytan Samadova, Melekber Sülüşoğlu Durul, Hali̇l İbrahi̇m Tuzlaci
Tuber Yield Amplification In Dahlia Variabilis L. Under Humic Acid And Fertilizer Combinations, Kedar Mahadev Gheware, Nomita Laishram, Arvinder Singh, Sarabdeep Kour, Sourav Sharma, Aytan Samadova, Melekber Sülüşoğlu Durul, Hali̇l İbrahi̇m Tuzlaci
Turkish Journal of Agriculture and Forestry
Dahlia variabilis L. is a valued tuberous ornamental crop grown worldwide for its attractive flowers. Optimizing nutrient management is crucial for maximizing dahlia growth and tuber yield. In this field study, we evaluated the combined effects of humic acid (HA) and chemical fertilizers on the tuber production of Dahlia variabilis L. A factorial randomized complete block design was used with treatments combining three fertilizer levels (100%, 75%, and 50% of recommended NPK dose) and multiple HA treatments. HA was applied as a soil amendment and foliar spray in combination with inorganic NPK fertilizer. Results showed that integrating HA with reduced …
Bioactive Compounds In Fruits Of Newly Introduced Sweet Cherry Cultivars In Herzegovina, Jasmina Aliman, Mirjana Radović, Ahmed Džubur, Jasna Hasanbegović, Dženan Vukotić, Aleksandra Šupljeglav Jukić, Senad Murtić, Mihajlo Lizdek
Bioactive Compounds In Fruits Of Newly Introduced Sweet Cherry Cultivars In Herzegovina, Jasmina Aliman, Mirjana Radović, Ahmed Džubur, Jasna Hasanbegović, Dženan Vukotić, Aleksandra Šupljeglav Jukić, Senad Murtić, Mihajlo Lizdek
Turkish Journal of Agriculture and Forestry
This study evaluated the biochemical characteristics and bioactive compounds of 3 newly introduced Italian sweet cherry cultivars (Sweet Valina, Sweet Stephany, and Sweet Gabriel) grown under the agroecological conditions of Herzegovina (Mostar and Trebinje). The analysis included total soluble solids, total acidity, sweetness index, total phenolic contents, total flavonoid contents, and antioxidant capacity in fruit skin and flesh. Significant differences were observed among cultivars, locations, and their interactions for most analyzed parameters. Fruits from Trebinje generally exhibited higher antioxidant capacity, total phenolic contents in the skin, soluble solids contents, and sweetness index values. Sweet Valina, particularly at the Trebinje location, …
Retraction Notice To “Characterization Of Tfiie-Regulated Genes By Transcriptome Analysis” [Turkish Journal Of Biology, Volume 48, Issue 6, Pages 442–455,Https://Doi.Org/10.55730/1300-0152.2718], Turkish Journal Of Biology
Retraction Notice To “Characterization Of Tfiie-Regulated Genes By Transcriptome Analysis” [Turkish Journal Of Biology, Volume 48, Issue 6, Pages 442–455,Https://Doi.Org/10.55730/1300-0152.2718], Turkish Journal Of Biology
Turkish Journal of Biology
This article has been retracted.
Following concerns raised after publication, the matter was referred to the TÜBİTAK Committee on Research and Publication Ethics (AYEK) for investigation. An Expression of Concern was published while the investigation was ongoing; it was published in the Turkish Journal of Biology, Volume 49, Issue 3, https://journals.tubitak.gov.tr/biology/vol49/iss3/11/.
The investigation has now been concluded. Based on the findings, the project idea and research design underlying the study were used without appropriate attribution or permission. The investigation also determined that a researcher who had contributed to the intellectual foundation of the work—including the development of the …
Evaluation Of Apoptosis In Peripheral Blood And Milk Immune Cells During Lactation In Dairy Cows With Subclinical Mastitis, Mykola Mykolayovich Zhelavskyi
Evaluation Of Apoptosis In Peripheral Blood And Milk Immune Cells During Lactation In Dairy Cows With Subclinical Mastitis, Mykola Mykolayovich Zhelavskyi
Turkish Journal of Veterinary & Animal Sciences
The lactation cycle is considered one of the most physiologically demanding periods in dairy cows and is accompanied by substantial immunological remodeling. In the present study, spontaneous apoptosis of lymphocytes, monocytes, and neutrophils was evaluated in clinically healthy Ukrainian Black and White dairy cows (n = 28, aged 3–5 years) during different stages of the lactation cycle: colostrum period (3–5 days), mid‑lactation (90–150 days), drying‑off (5–7 days), and dry period (12–20 days). A further group of 28 cows with subclinical mastitis confirmed by the California Mastitis Test was also included in the study. Peripheral blood and milk samples were collected …
Valuation Methods And Their Relevance In Achieving Marine Protected Areas Targets: A Systematic Review, Jacob Ankamah, Stephen Hynes, Daragh O'Leary
Valuation Methods And Their Relevance In Achieving Marine Protected Areas Targets: A Systematic Review, Jacob Ankamah, Stephen Hynes, Daragh O'Leary
Journal of Ocean and Coastal Economics
The prolific human-induced pressures on marine ecosystems leading to negative externalities such as beach erosion, biodiversity loss, and climate change are matters of global concern. Marine protected areas (MPAs) have emerged as a tool to conserve marine biodiversity and support human livelihoods. This paper reviews the global research landscape, the evolution of concepts and the relevance of valuation techniques related to the assessment of the contribution of MPAs to societal welfare. The review indicates that less than 3% of the wider MPA literature explores the economic valuation of MPA designation. Of those, there is an obvious preference for non-market-based methods …
Antibiotic Resistance Genes In Diabetic Foot Ulcer Microbiomes: Molecular Mechanisms And Clinical Management Strategies, Fitra Adi Prayogo
Antibiotic Resistance Genes In Diabetic Foot Ulcer Microbiomes: Molecular Mechanisms And Clinical Management Strategies, Fitra Adi Prayogo
Chulalongkorn Medical Journal
Background: Diabetic foot ulcers (DFUs) affect 19-34% of diabetic patients lifetime, representing a major global health burden with over 18 million cases annually. The polymicrobial nature of DFU infections, combined with emerging antibiotic resistance genes, poses unprecedented clinical management challenges. Methicillin-resistant Staphylococcus aureus (MRSA) prevalence reaches 84% and extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae exceeds 50% in some regions, creating urgent therapeutic concerns.
Objective(s): This comprehensive review examines current understanding of microbial communities in diabetic foot ulcers and their associated resistome, analyzing molecular mechanisms underlying antibiotic resistance and clinical implications to identify evidence-based management strategies.
Methods: A narrative review approach was …
Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao
Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao
Pharmacy Faculty Articles and Research
Emerging tools for spatial analysis, systems biology, and synthetic biology offer opportunities to observe, dissect, and perturb cancer mechanisms, to design strategies for the prevention of oncogenesis, and to identify therapies that lead to durable tumor control. Here, we summarize perspectives from the virtual Innovation Lab on “Synthetic and Systems Approaches to Interrogate Spatiotemporal Processes in Cancer” (S3) hosted by the National Institutes of Health (NIH), which assembled interdisciplinary experts to discuss cancer spatial organization and dynamic cellular interactions and how they can be addressed by leveraging novel synthetic and systems biology approaches. These discussions focused especially on cancer initiation, …
Community-Based Water Management Through Cultural Ecosystem Services: Traditional Wisdom And Modern Adaptation In Senjoyo Spring, Indonesia, Puji Winarti, Sri Haryani, Sri Wardani, Langlang Handayani
Community-Based Water Management Through Cultural Ecosystem Services: Traditional Wisdom And Modern Adaptation In Senjoyo Spring, Indonesia, Puji Winarti, Sri Haryani, Sri Wardani, Langlang Handayani
Journal of Environmental Science and Sustainable Development
Small-scale freshwater ecosystems play vital ecological and cultural roles. However, community-based water management (CBWM) often lacks a clear analytical approach to integrating cultural ecosystem services (CES) and traditional ecological knowledge (TEK), limiting the practical understanding of culturally grounded governance. To address this gap, this qualitative study explores the interactions between CES and TEK, analyzes their roles within CBWM, and identifies their implications for sustainable water governance. The integration between cultural value and local ecological knowledge makes Senjoyo Spring an appropriate location for this study. Data were collected through interviews with 20 key informants, field observations, forum group discussions (FGDs), and …
Pi3kδ Inhibition Alters Cd8 T Cell Differentiation And Reprograms The Tumor Microenvironment Following Adoptive Immunotherapy, Alexandrea Joy Turnquist
Pi3kδ Inhibition Alters Cd8 T Cell Differentiation And Reprograms The Tumor Microenvironment Following Adoptive Immunotherapy, Alexandrea Joy Turnquist
Dartmouth College Ph.D Dissertations
T cell exhaustion remains a significant barrier to effective adoptive cell therapy in solid tumors. Here, we demonstrate that in vitro treatment with the PI3Kδ inhibitor CAL-101 generates T cells with enhanced stemness and metabolic fitness, though the stemness of these cells is not dependent on HIF-1α -dependent mechanisms. These cells show increased mitochondrial dependence and spare respiratory capacity while maintaining normal basal metabolism. Under chronic antigen stimulation, CAL-101-treated T cells, including human T cells, resist terminal exhaustion and maintain stem-like properties. Using single-cell RNA sequencing and spatial transcriptomics of B16 melanoma tumors, we found that CAL-101-treated T cells preferentially …
Marine Spatial Planning In The Asean Countries: Lesson Learned For Future Ocean Governance In Malaysia, Husni Alhan Md Salimun, Mohd Fadzil Akhir, Nazli Aziz, Che Din Mohd Safuan, Wan Izatul Asma Wan Talaat
Marine Spatial Planning In The Asean Countries: Lesson Learned For Future Ocean Governance In Malaysia, Husni Alhan Md Salimun, Mohd Fadzil Akhir, Nazli Aziz, Che Din Mohd Safuan, Wan Izatul Asma Wan Talaat
Journal of Environmental Science and Sustainable Development
Marine Spatial Planning (MSP) has emerged as an important governance instrument for balancing ecological protection, economic development, and social inclusion amid the rapidly intensifying blue economy in Southeast Asia. Although several ASEAN Member States (AMS) have initiated MSP processes, the existing literature on MSP governance in this region remains fragmented and largely descriptive, limiting systematic cross-country comparison and evidence-based lessons. This study addresses this gap by assessing MSP governance performance across ASEAN countries and againts internationally recognized MSP governance benchmarks. A structured narrative review was conducted using selected PRISMA-informed procedures for literature identification and screening. Academic publications from 2003 to …
Decentralized Renewable Energy And Sustainability By Integrating Solar Ovens Into Urban Living, Nuno Soares Domingues
Decentralized Renewable Energy And Sustainability By Integrating Solar Ovens Into Urban Living, Nuno Soares Domingues
Journal of Environmental Science and Sustainable Development
Urban households account for a substantial share of global energy consumption and greenhouse gas emissions, with domestic cooking representing an often-overlooked component of residential energy demand. Low-cost solar cooking technologies offer a promising pathway towards urban decarbonization by harnessing renewable solar energy while reducing dependence on grid electricity and promoting circular resource use. This study evaluates the contribution of two experimentally developed low-cost solar box ovens to urban sustainability under Mediterranean climatic conditions in Lisbon, Portugal. A recycled cardboard prototype and a timber-based prototype were assessed through controlled outdoor experiments involving thermal performance, cooking capability, energy savings, and environmental evaluation. …
Good Governance In The Concept Of Climate Justice: Decarbonisation Policies In Economic Considerations Of Losses And Sacrifices, Daryanti Daryanti, Albertus Sentot Sudarwanto, Erna Dyah Kusumawati, Rosita Candrakirana
Good Governance In The Concept Of Climate Justice: Decarbonisation Policies In Economic Considerations Of Losses And Sacrifices, Daryanti Daryanti, Albertus Sentot Sudarwanto, Erna Dyah Kusumawati, Rosita Candrakirana
Journal of Environmental Science and Sustainable Development
Projections of losses resulting from the impacts of climate change in Indonesia are estimated to reach USD 30.5 million, affecting four key sectors: agriculture, water supply, health, and the maritime sector. This study shows that good governance based on climate justice in the implementation of decarbonization policies is the most important factor in avoiding long-term economic losses caused by the adverse impacts of climate change or investing in climate resilience. This study employed a normative methodology using a statutory approach to examine efforts related to climate change mitigation and adaptation. The findings of this research indicate that regulations in Indonesia, …
Realities Of Engendering Federalization: Political Commitment To Gender Equality, Resources, And Policy, Christine S. Diaz
Realities Of Engendering Federalization: Political Commitment To Gender Equality, Resources, And Policy, Christine S. Diaz
Journal of Public Affairs and Development
Amid several initiatives to federalize the Philippines, discourse on engendering federalization remains scarce. This gap forms the basis of this study, which examined the realities of engendering federalization. Data were gathered through in-depth interviews and key informant interviews with research participants from various sectors in Davao City. Guided by Caren Levy’s Web of Institutionalization Framework, the study focused on three core dimensions: political commitment to gender equality, resources, and policy. The findings revealed that engendering federalization, particularly political commitment to gender equality, requires advocacy, institutionalization, gender awareness, and gender-sensitivity formation. Institutional mechanisms, policies, and resources are important for advancing gender-responsive …
A Comprehensive Review Of Current Trends And Future Prospects In Drug Resistance Of Leishmania Species, Sarah Kamal Naser
A Comprehensive Review Of Current Trends And Future Prospects In Drug Resistance Of Leishmania Species, Sarah Kamal Naser
Maaen Journal for Medical Sciences
Leishmaniasis, which is an infectious tropical disease that is caused by Leishmania protozoa, continues to be a leading global public health problem. This disease is prevalent in about 89 countries, with over one billion individuals being at risk of infection. Current treatments have many limitations, and the efficacy of currently available leishmanial drugs has been undermined by the development of resistant strains of Leishmania. This review highlights the prevailing patterns regarding drug resistance in Leishmania and looks forward to future ways to deal with this problem. The genomic plasticity seen in Leishmania, which includes aneuploidy, gene amplification, chromosome rearrangement, and …
Radiological And Chemical Safety Assessment Of Drinking Water From Treatment Plants And Rivers In Kut City, Iraq, Ahmed A. Alswaty, Hadi D. Alattabi
Radiological And Chemical Safety Assessment Of Drinking Water From Treatment Plants And Rivers In Kut City, Iraq, Ahmed A. Alswaty, Hadi D. Alattabi
Karbala International Journal of Modern Science
Climate change and increasing anthropogenic activities, particularly wastewater discharge into rivers, have raised pollution levels in the water sources of Kut City, necessitating an assessment of the radiological and chemical safety of drinking water at the city's treatment plants. Thirteen water samples were collected, comprising ten treated and three raw water samples from the source rivers. An HPGe detector was used to measure the radionuclides 214Bi, 214Pb, 212Bi, 212Pb, 40K, and 137Cs. All measured radionuclides were below the minimum detectable activity (MDA). ICP-OES analysis supported these findings, as U concentrations in most samples were …
Silverleaf Nightshade (Solanum Elaeagnifolium) Undergoes Guild-Specific Transcriptomic Reprogramming Against Chewing Versus Piercing Sucking Herbivory, Arunsaikumar Karrem, Matthew Terry, Jagdish Jaba, Rupesh R. Kariyat
Silverleaf Nightshade (Solanum Elaeagnifolium) Undergoes Guild-Specific Transcriptomic Reprogramming Against Chewing Versus Piercing Sucking Herbivory, Arunsaikumar Karrem, Matthew Terry, Jagdish Jaba, Rupesh R. Kariyat
School of Integrative Biological & Chemical Sciences Faculty Publications
Solanum elaeagnifolium (silverleaf nightshade, SLN) is a globally invasive perennial weed with reproductive plasticity and complex defence systems that significantly impact crop yields by invading fields of staple, commercial and ornamental crops. Despite being a host to multiple insect herbivores, the molecular programming enabling its rapid adaptation to defend against diverse feeding guilds remains poorly resolved. Here, we report a comprehensive de novo transcriptomic assembly and comparative analysis of S. elaeagnifolium challenged by two distinct herbivores: the piercing-sucking generalist cowpea aphid, Aphis craccivora and the chewing specialist tobacco hornworm, Manduca sexta. Differential gene expression analysis revealed a massive difference …